Their findings outlined four distinct cellular phases of sperm
stem cells maturation, revealing how the stem cells progress from a «quiescent» state, to a «proliferation» state during which stem cells divide, to a final «differentiation» state when stem cells mature to become sperm.
Specifically, we're focused on
stem cell maturation — taking a cell from an immature to a more mature state so that it acts as a better substrate for adult tissue functions.
Not exact matches
In the bone marrow, blood
stem cells give rise to a large variety of mature blood
cells via progenitor
cells at various stages of
maturation.
The findings indicate that let - 7 microRNAs are necessary and sufficient to drive the
maturation of
stem cell - derived cardiomyocytes, Ruohola - Baker said.
The transplanted
stem cells differentiated to different types of
cells with variable level of
maturation, specific for the nervous system.
The study, which was led by postdoc Gregor Pilz and PhD student Sara Bottes, used in vivo 2 - photon imaging and genetic labeling of neural
stem cells in order to observe
stem cell divisions as they happened, and to follow the
maturation of new nerve
cells for up to two months.
Future studies should explore whether
stem cells elsewhere in the body undergo a similar premature
maturation, he says.
LOCATING PRE-HEMATOPOIETIC
STEM CELLS Researcher: Fuchou Tang, Assistant Professor, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University Project: In a study published in Nature, Tang and his collaborators isolated pre-hematopoietic stem cells (HSCs) for the first time and showed their unique transcriptome signatures before and during their maturation into HSCs (533:487 - 92, 20
STEM CELLS Researcher: Fuchou Tang, Assistant Professor, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University Project: In a study published in Nature, Tang and his collaborators isolated pre-hematopoietic stem cells (HSCs) for the first time and showed their unique transcriptome signatures before and during their maturation into HSCs (533:487 - 92, 2
CELLS Researcher: Fuchou Tang, Assistant Professor, Biodynamic Optical Imaging Center, Integrated Science Research Center, Peking University Project: In a study published in Nature, Tang and his collaborators isolated pre-hematopoietic
stem cells (HSCs) for the first time and showed their unique transcriptome signatures before and during their maturation into HSCs (533:487 - 92, 20
stem cells (HSCs) for the first time and showed their unique transcriptome signatures before and during their maturation into HSCs (533:487 - 92, 2
cells (HSCs) for the first time and showed their unique transcriptome signatures before and during their
maturation into HSCs (533:487 - 92, 2016).
Maturation of human embryonic
stem cell - derived pancreatic progenitors into functional islets capable of treating pre-existing diabetes in mice.
Osteo -
maturation of adipose - derived
stem cells required the combined action of vitamin D3, β - glycerophosphate, and ascorbic acid.
Effects of mesenchymal
stem cells on differentiation,
maturation, and function of human monocyte - derived dendritic
cells.
Non-cardiomyocytes influence the electrophysiological
maturation of human embryonic
stem cell - derived cardiomyocytes during differentiation.
The team used genetically engineered mice to study the effects of different human apoE variants on the
maturation of neural
stem cells or progenitor
cells, from which new neurons develop in the adult brain.
By combining new systems biological analyses and advanced data analysis, a recent study led by Petter Brodin (Karolinska Institutet / SciLifeLab) have been able to monitor the
maturation process of the immune system in leukaemia patients who have undergone
stem cell transplantation.
Among its other roles, SIRT6 plays a large part in
cell division and, as Mostoslavsky has found, the
maturation of embryonic
stem cells into their adult forms.
In their study, published alongside Deng's in
Cell Stem Cell, the researchers converted human fibroblasts to neurons using a combination of seven molecules applied to the
cells for one week, followed by a three - week
maturation period in a medium containing two of the reprogramming molecules and one other molecule.