Vet - Stem out of San Diego, California is the first company in the U.S. to use
stem cells processed from your dog's fatty tissues in regenerative medicine.
The pluripotent
stem cell process could allow researchers to make genetic changes to dampen or potentially eliminate the rejection of the pig islets by the human immune system.
Not exact matches
The
process takes a person's
cells (blood, skin) and converts them into
stem cells.
Making personalized, or «autologous»
stem -
cell treatments, can make the
process go a lot faster, since a person's
cells don't need to be shipped out, reprogrammed, then reinserted into the body.
Embryonic
stem cells are produced during development by the same
process of epigenetic programming that later will produce adult
cells such as skin and brain.
One proposal that has received considerable scientific support has been to generate non-embryonic entities that can serve as a source of
stem cells through a
process termed Altered Nuclear Transfer (or ANT).
The
stem cells are harvested,
processed and then «cryopreserved» (a fancy word for freezing) at a bank for your potential future medical use.
However, since there are simply not enough
stem cells in cord blood alone to treat an adult sized patient, Americord offers a proprietary
process for storing the entire placenta and preserving up to 10 times more
stem cells than cord blood banking alone.
But harvesting requires invasive surgery, and bestowing
stem cell properties on adult
cells takes a two - step
process that can increase the risk of the final
cells becoming cancerous.
Treating the skin
cells with a biochemical cocktail to promote neural
stem cell characteristics seemed to do the trick, turning it into a one - step
process, he and his colleague report today in Science Translational Medicine.
They turned the fibroblasts into
stem cells and noticed that in the
process, some of the
cells lost the extra sex chromosome.
To solve these problems, Hingtgen's group wanted to see whether they could skip a step in the genetic reprogramming
process, which first transforms adult skin
cells into standard
stem cells and then turns those into neural
stem cells.
In addition to maintaining
stem cell populations and keeping the brain supplied with all its
cell types, the investigators showed that NAD also is vital for the
process of cognition itself.
Adult neural
stem cells in the hypothalamus — a brain region that regulates hunger, sleep, body temperature and other activities — appear to orchestrate the body's aging
process, they found.
The
process is painstaking and involves the systematic «knockout» — removal — of relevant genes in
stem cell cultures.
Speeches came from a variety of speakers, including a science broadcaster and writer, a Pakistani - born Canadian Muslim who works in
STEM, a Pakistani - born professor who studies
cell biology and anatomy; and, an emergency room physician who helped start the
process to phase out coal - fueled power plants by 2030 in Alberta.
Research shows its
stem cells also impact the aging
process.
Both diseases result from the death of retinal
cells, a
process that Lanza suspects can be slowed or even halted using
stem -
cell - derived replacements.
One of the molecular mysteries hindering development of regenerative therapy for muscles is uncovering the precise genetic and molecular
processes that cause skeletal muscle
stem cells (called myoblasts) to fuse and form the striated muscle fibers that allow movement.
Nishimura's team proposes that the same
process leads to the reduction in
stem cells in the follicles of older people, especially as DNA damage accumulates as we age.
This is not to say that
stem cells are not necessary to the
process, however, because the cellular dedifferentiation
process in urodeles is often presented as a means to locally generate pluripotent
cells (perhaps
stem cells or
cells very similar to them).
This intricate regulation
process allows
stem cells to maintain their ability to undergo self - renewal and form blood vessel - like structures.
The study results were found using mouse embryonic
stem cells, which are good
cell models for the study of
processes seen in human
stem cells.
Cancer
stem cells can reproduce themselves through a
process called self - renewal and sustain the growth of a tumor.
However, it remains unclear how these different
stem cells populations balance proliferation, differentiation and migration during the healing
process.
«The massive advantage with our stain-less laser - based imaging approaches is that you can use the
stem cell sample without having to interrupt the developmental
process in real time, you don't need to perform any
cell disruption and there is no photobleaching (fading) which is fairly common with fluorescent material,» Catarina enthused.
After deciphering this natural differentiation
process, the investigators duplicated it in the laboratory dish by adding a sequence of proteins, called growth factors, to the fluid bathing the
stem cells.
The latest findings show that genetic defects in the body's ability to manufacture carnitine might be associated with an increased risk of autism because carnitine deficiency interferes with the normal
processes by which neural
stem cells promote and organize embryonic and fetal brain development.
Ordinarily, so drastic a makeover would require the creation of so - called induced pluripotent
stem (iPS)
cells and then turning these into neurons, an inefficient
process that can take weeks.
Setton says the multistep
process her lab used to derive NP - type
cells from the hiPSCs provides the necessary quality control as scientists seek additional uses for
stem cell therapies.
The Salford team set out to assess the bioenergetics of cancer
stem cells — the
processes which allow the
cells to live and thrive — with a view to disrupting their metabolism.
Adding
stem cells from human bone marrow to a broken diabetic bone enhances the repair
process, increasing the strength of the newly formed bone, according to a laboratory - based study presented at the European Congress of Endocrinology in Dublin.
«If we win, the entire regulatory structure for autologous
cell processing, with or without culture, will be rewritten such that any physician using good practices and treating patients responsibly can use
stem cells as part of his or her medical practice,» he says.
While the
process usually proceeds in a one - way direction, artificially inducing the activity of key transcription factors can reprogram differentiated
cells back into a
stem - like state, a discovery honored with the 2012 Nobel prize.
Several studies have used
cell - surface markers — proteins found on the outer membranes of tumor
cells — to identify glioblastoma
stem cells; but the specific markers used have been controversial and can not reflect molecular
processes going on within tumor
cells.
The company isolates, cultures and
processes adult
stem cells from a patient's bone marrow or synovial fluid.
This
process endows them with pluripotency, or the ability to become any type of
cell, including neural
stem cells.
«leukemia results from the gradual accumulation of DNA mutations in blood
stem cells, in a
process that can take decades,» explains Dr Thomas McKerrell, joint first author from the Wellcome Trust Sanger Institute.
This is because larger brain parts are thought to have a later and longer
process of neurogenesis — the development of neurons or nerve
cells from neural
stem cells and progenitor
cells.
The
process prepares the patient's body to accept the donated
stem cells, reducing the risk of rejection and providing a hospitable environment for the new
cells to engraft, thrive and produce new blood and immune
cells.
Directing
stem cell differentiation is like following a complex recipe, involving a long list of ingredients and steps that make the
process costly and inefficient.
Under the Obama administration, the number of embryonic
stem cell lines available for federally funded research had more than tripled, but no money was going toward the creation of any
cell lines (a
process that destroys the embryo).
The authors believe that these tools and methods will lay the foundation for crucial breakthroughs in the flatworm model system and in our understanding of
stem cell biology and the
process of regeneration.
Using a mouse model, the team also demonstrated that two
processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal
stem cells that have the potential to become multiple different kinds of
cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.
«If we can identify the point at which tumor
cells acquire the characteristics of
stem cells, it will be possible to look for ways to interrupt the
process and avoid progression of the disease.»
«Disturbances to these
processes may cause neuronal
stem cells to develop into different types of
cells or may cause neurons to migrate to different locations in the brain, changing neuronal circuitry and potentially leading to behavioral disorders like schizophrenia.»
The researchers reprogrammed the
cells to create induced pluripotent
stem cells in an FDA - compliant facility at the Broad Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical tri
stem cells in an FDA - compliant facility at the Broad
Stem Cell Research Center; the use of this facility is an important step in the process as preclinical research moves toward human clinical tri
Stem Cell Research Center; the use of this facility is an important step in the
process as preclinical research moves toward human clinical trials.
This method would also enable them to follow potential aging
processes that occur in blood
stem cells in detail as they occur naturally in a living organism.
The researchers have now reported in the journal Nature that the normal
process of blood formation differs from what scientists had previously assumed when using data from
stem cell transplantations.
Blood formation was the first
process for which scientists formulated and proved the theory that
stem cells are the common origin that gives rise to various types of mature
cells.