Sentences with phrase «stem cells studies on»

New perspective piece highlights the regulatory, ethical and scientific issues associated with U.S. «stem cell clinics» registering pay - to - participate stem cells studies on the NIH registry and database, ClinicalTrials.gov.

Not exact matches

This study, to appear in the journal Cell Stem Cell on April 5, counters that notion.

According to the study results, YAP is excluded from the nucleus on the soft gels, and its depletion there helps drive the stem cells onto a brain cell developmental pathway.

Although the U.S. government puts stringent restrictions on funding for research on embryonic stem cells, individual states such as California have set up institutes to perform that work and general stem cell studies.

Now, in a new study published today, Sept. 8, in the Proceedings of the National Academy of Sciences, a team of researchers from the University of Wisconsin - Madison has added a new wrinkle to the cell differentiation equation, showing that the stiffness of the surfaces on which stem cells are grown can exert a profound influence on cell fate.

Several studies have used cell - surface markers — proteins found on the outer membranes of tumor cells — to identify glioblastoma stem cells; but the specific markers used have been controversial and can not reflect molecular processes going on within tumor cells.

A study analyzing brain tumor genomics on a single - cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow - growing but incurable form of brain cancer.

Another problem is that in its July 2009 Guidelines on Human Stem Cell Research, NIH spelled out specific requirements about embryo donation for newly derived lines, says Pilar Ossorio, a legal scholar who studies research ethics at the University of Wisconsin Law School.

Studying mice with injuries to the lining of the stomach, the researchers blocked the animals» ability to call on stem cells for help in the stomach.

This study provides a new mathematical model that could be incorporated into future computational studies on mesenchymal stem cells.

«The potential advantage of stem cells,» says Eugene Redmond, a professor of neurosurgery at the Yale University School of Medicine and the lead author of that study, «is that they still have the potential to migrate and position themselves in appropriate places depending on what signals are there [in the brain].»

Sheng Ding, PhD, a senior investigator in the Roddenberry Stem Cell Center at Gladstone and co-senior author on the study, adds, «This new cellular reprogramming and expansion paradigm is more sustainable and scalable than previous methods.

«Interestingly, we also found that vitamin C treatment had an effect on leukemic stem cells that resembled damage to their DNA,» says first study author Luisa Cimmino, PhD, an assistant professor in the Department of Pathology at NYU Langone Health.

«From the current research atmosphere and infrastructure, the government has judged that stem - cell studies are now maturing,» says Hyung Min Chung, president of Seoul - based biotechnology firm Cha Bio and Diostech and an adviser on the budget plan.

«Lenalidomide maintenance following autologous stem cell transplant can now be considered a standard of care for people with multiple myeloma,» says Dr. McCarthy, senior author on the meta - analysis and Principal Investigator of the U.S. study, CALGB (Alliance) 100104.

The mini-brain lasts about a month and it could be used to study a range of challenges in neuroscience including transplanting nerve cells that could help treat Parkinson's disease and studies on how adult nerve stem cells develop.

A study in the International Society for Stem Cell Research's journal Stem Cell Reports, published by Cell Press on November 20 shows that a Sox2 protein, alone or in combination with another protein, Ascl1, can cause nonneuronal cells, called NG2 glia, to turn into neurons in the injured cerebral cortex of adult mice.

«Proper blood cell production is dependent on functioning hematopoietic stem and progenitor cells that are destroyed during conditioning procedures for transplantation or following bone marrow injury,» said the study's first author Kevin A. Goncalves, who performed this research as part of his PhD studies in cellular and molecular physiology at the Sackler School.

The teams are currently working on the fabrication of 3D structures from the blend suitable for implantation in patient joints with future studies focusing on understanding the peculiar interactions between the blend and stem cells towards refining the quality of regenerated cartilage.

For this study, Nakano and his collaborators used cancer cells from 40 patients with high - grade gliomas, focusing on tumor cells with a stem - cell signature.

A caveat of the study is that the gel does not exactly replicate the microenvironment inside the body, so it's not clear whether stem cells behave differently on the designed gel surfaces.

One metabolite featured in the study is cholesterol sulfate, which was found to be used up during osteogenesis on a rigid matrix and in turn could be used to convert stem cells into bone - like cells in a dish.

Human epidermal equivalents representing different types of skin could also be grown, depending on the source of the stem cells used, and could thus be tailored to study a range of skin conditions and sensitivities in different populations.»

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

But the Harvard stem cell and regenerative biologist Amy Wagers, a co-author on three of the mouse papers, said in an email to STAT that she does not agree that her teams» studies provide a scientific basis for Maharaj's clinical trial.

«To date, there has been no systematic means of assessing the fidelity of cellular engineering — to determine how closely cells made in a petri dish approximate natural tissues in the body,» says George Q. Daley, MD, PhD, Director of the Stem Cell Transplantation Program at Boston Children's and senior investigator on both studies.

Recent studies showed that low oxygen conditions increase levels of a family of proteins known as HIFs, or hypoxia - inducible factors, that turn on hundreds of genes, including one called NANOG that instructs cells to become stem cells.

In the context of the current study, the researchers have developed a pre-clinical model system that specifically captures the impact of a treatment on cancer stem cells.

Studies of embryonic stem cells revealed that NANOG protein levels can be lowered by a chemical process known as methylation, which involves putting a methyl group chemical tag on a protein's messenger RNA (mRNA) precursor.

«Ever since 2004, the studies on stem cell research and infertility have been surrounded by hype.

The researchers have isolated the sesquiterpene lactone damsin from the plant and studied its effect on cancer stem cells in three different breast cancer cell lines.

Ko first cloned the human GT198 gene while a postdoctoral fellow at Harvard Medical School, and subsequent studies by her and others have shown it has multiple roles that also include regulating stem cells, cell suicide and turning other genes off and on.

«Every so often we would see a green spot on a fish,» says Leonard Zon, MD, director of the Stem Cell Research Program at Boston Children's and senior investigator on the study.

The researchers used the new lab - on - a-chip to study how adult stem cells in adipose tissue develop into mature fat cells, conducting their investigations outside the body.

Co-authors on the study were Christian Mosimann (University of Zürich), Zi Peng Fan (Whitehead Institute and MIT), Justin Tan (Genome Institute of Singapore), Richard White (Memorial Sloan Kettering Cancer Center), Dominick Matos (Massachusetts General Hospital), Ann - Christin Puller (University Medical Center Hamburg - Eppendorf, Germany), Eric Liao (Harvard Stem Cell Institute and MGH) Richard Young (Whitehead Institute and MIT), and, at Boston Children's Hospital, Song Yang, Andrew Thomas, Julien Ablain, Rachel Fogley, Ellen van Rooijen, Elliott Hagedorn, Christie Ciarlo and Cristina Santoriello.

«Scientists discover stem cells that build a fly's nervous system: Study in fruit flies sheds light on key aspect of development; findings could build understanding of comparable system in people.»

On 1 July, Italian Health Minister Beatrice Lorenzin appointed a scientific committee to coordinate the study, which includes the heads of the Superior Health Institute, the National Italian Transplant Centre, and the Italian Medicines Agency, along with Italian stem cell scientists.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

«Research using human fetal tissue is invaluable to scientific and medical communities worldwide that study and work on human development and disease,» said Hans Clevers, president of the International Society for Stem Cell Research (ISSCR), and a stem cell researcher at Utrecht University in the Netherlands, in a statement released 14 JStem Cell Research (ISSCR), and a stem cell researcher at Utrecht University in the Netherlands, in a statement released 14 JCell Research (ISSCR), and a stem cell researcher at Utrecht University in the Netherlands, in a statement released 14 Jstem cell researcher at Utrecht University in the Netherlands, in a statement released 14 Jcell researcher at Utrecht University in the Netherlands, in a statement released 14 July.

The study, published in Nature Medicine on November 16, 2015, is the first to show that Duchenne muscular dystrophy directly affects muscle stem cells.

A new study, however, provides insights on the cellular mechanisms that might be targeted to help certain stem cells - called human mesenchymal stem cells (hMSCs)- maintain properties needed to make them clinically useful.

This study has shed light for the first time on the importance of fat stem cells in the context of diabetes.

Weissman says that most clinical studies of stem cells fail to meet what he sees as key criteria: They should be based on clear, peer - reviewed demonstrations of tissue regeneration, replicated by a large number of independent groups that provide rapid, long - lasting benefits.

«This lets us keep age - related signatures in the cells so that we can more easily study the effects of aging on the brain,» says Rusty Gage, a professor in the Salk Institute's Laboratory of Genetics and senior author of the paper, published October 8, 2015 in Cell Stem Cell.

The new approach builds on information gleaned from developmental studies of embryonic stem cells (see story # 16) and one day may be used to create healthy replacements for harmed or diseased tissue.

In the new study, the researchers cultured mouse skin - cancer colonies on various 2 - D and 3 - D environments of different shapes and patterns to see if the tumor shape contributes to activation of cancer stem cells, and to see where in the tumor the stem cells appeared.

Anguera's studies found that, in some cases, stem cells lose both Xist expression and the modifications that normally reside on the inactive X.

In a response to Friday's decision, NIH spokesperson John Burklow said NIH doesn't set aside fixed amounts of money for studying adult or embryonic stem cells, but instead makes award decisions based on scientific merit and relevance to NIH's priorities.

«The focus of chemotherapy and existing standard - of - care is on killing cancer cells but instead we took a completely different approach which changes the environment the cancer cells live in,» said Mick Bhatia, director and senior scientist with the McMaster Stem Cell and Cancer Research Institute, who led the group that performed the study.

When politicians want to cut funding, he notes, they focus on specific controversial studies or areas — such as climate change, stem cells or genetically modified organisms.