Not exact matches
And a new analysis
of the
STEP trial, published last November in Proceedings
of the National Academy
of Sciences USA, provides a warning that the very vectors (adenoviruses, which are also employed in other
vaccine development work) used to distribute the inactive HIV strains can actually make the immune system more vulnerable to infection by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.
This breakthrough discovery is a major
step forward towards the
development of an asthma
vaccine.
After
stepping down as head
of the Centers for Disease Control and Prevention (CDC) almost a year ago, Julie Gerberding has a new gig: She will preside over
vaccine development at the drug giant Merck.
And a new analysis
of the stopped
STEP trial, published online Monday in Proceedings in the National Academy
of Sciences, provides a warning that the very vectors (adenoviruses, which are also employed in other
vaccine development) used to distribute the inactive HIV strains can actually prime the immune system to be infected by recruiting susceptible T cells to mucous membranes, where they are more likely to be infected during sexual activity.
The next
step, they say, is the
development of a BYD
vaccine.
Col. Nelson Michael, the WRAIR Zika program co-lead, said, «This critical first
step has informed our ongoing work in non-human primates and gives us early confidence that
development of a protective Zika virus
vaccine for humans is feasible.»
Now, however, the pioneering
vaccine development project has ended, and MVP and partners are working with African government health officials to carefully plan for the next
steps in the continued deployment
of MenAfriVac ®.
In Australia, researchers have been working on a chlamydia
vaccine for koalas, which may also be a
step towards
development of a human
vaccine.
Where that
step will lead will depend, among other things, on the fate
of MVA, another milder
vaccine that's much further along in
development (ScienceNOW, 10 March).
BETHESDA, MARYLAND — It's time for bold
steps to boost
development of vaccines for the world's main killers — AIDS, malaria, and tuberculosis — according to a range
of experts gathered here 22 to 23 May.
Vinetz said the next
step will be to begin exploiting the genomic information «for
vaccine and diagnostics
development, experimental approaches to understanding mechanisms
of disease pathogenesis and how Leptospira persist in the environment, all critical for developing new public health interventions aimed at reducing the global impact
of this important but neglected zoonotic disease.»
Dr Peter Barlow says study represents a promising
step forward in the rapid
development of a safe and robust
vaccine against Zika virus infection in humans.
Finally, the plans for the future
development of the
vaccine and the next
steps to phase II clinical trial were presented.
Since then I learned some techniques from an experienced Hollywood script
development exec, like starting with a one - sentence log line (the first sentence
of my description
of Vaccine Nation above is one, a bit long at 36 words) that captures the story, and then build the outline, including key dramatic
steps, in three acts from there.