Sentences with phrase «stimulate apoptosis»

Not only do controllers have more CD8 T cells, each cell produces greater quantities of perforin and granzymes, which stimulate apoptosis, or cell death.

Not exact matches

There, depending on what other chemical signals are present, the GAPDH can either stimulate the neuron's growth or activate a self - destruct program — called apoptosis — that will kill the neuron.

Apoptosis stimulated by the 91 - kDa caspase cleavage MEKK1 fragment requires translocation to soluble cellular compartments.

Human Cytomegalovirus Interacts with Toll - like Receptor 2 and CD14 on Syncytiotrophoblasts to Stimulate Expression of TNFα mRNA and Apoptosis.

Oxidant - mediated mitochondrial injury in eosinophil apoptosis: enhancement by glucocorticoids and inhibition by granulocyte - macrophage colony - stimulating factor.

Estrogen demonstrated protective effects from β - cell apoptosis (201), stimulates β - cell secretion (202) and improves insulin sensitivity (203) with antidiabetic effects primarily described to ERα (68, 204).

Akt stimulates glucose uptake, glycogen synthesis, and protein synthesis via Akt / mTOR and Akt / GSK -3 β signaling networks and inhibits apoptosis and protein degradation in skeletal muscle by inactivating FoxO transcription factors leading to increased lean mass.

A study published in the Journal of Agricultural and Food Chemistry showed that in addition to strawberries, blueberries and black raspberries, blackberries, cranberries and red raspberries also had anti-cancer benefits, inhibiting cancer growth and stimulating cancer cell apoptosis in vitro.

For example, KBs were recently reported to act as neuroprotective agents by raising ATP levels and reducing the production of reactive oxygen species in neurological tissues, 80 together with increased mitochondrial biogenesis, which may help to enhance the regulation of synaptic function.80 Moreover, the increased synthesis of polyunsaturated fatty acids stimulated by a KD may have a role in the regulation of neuronal membrane excitability: it has been demonstrated, for example, that polyunsaturated fatty acids modulate the excitability of neurons by blocking voltage-gated sodium channels.81 Another possibility is that by reducing glucose metabolism, ketogenic diets may activate anticonvulsant mechanisms, as has been reported in a rat model.82 In addition, caloric restriction per se has been suggested to exert neuroprotective effects, including improved mitochondrial function, decreased oxidative stress and apoptosis, and inhibition of proinflammatory mediators, such as the cytokines tumour necrosis factor - α and interleukins.83 Although promising data have been collected (see below), at the present time the real clinical benefits of ketogenic diets in most neurological diseases remain largely speculative and uncertain, with the significant exception of its use in the treatment of convulsion diseases.