Sentences with phrase «stimulated cell proliferation»

CNIO researchers have now discovered how the MCRS1 protein — a protein associated with gene regulation and cell death processes — is capable of activating mTOR, and thus, stimulate cell proliferation.

Loss of this function causes tumor formation through uncontrolled stimulation of AKT, an enzyme that stimulates cell proliferation and survival and is often hyperactive in human tumors.

When KRAS is mutated it stimulates cell proliferation, an essential step in cancer development.

Ohara, H. Ichikawa, S. Matsumoto, H. Akiyama, M. Fujimoto, N. Kobayashi, T. and Tajima, S. (2010) Collagen — derived dipeptide, proline - hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts.

It has gentle Bamboo Bead microdermabrasion to reveal youthful - looking skin while Glycolic and Salicylic Acids stimulate cell proliferation.

Not exact matches

EGF, TGF - alpha, and human milk stimulate fetal small intestinal cell proliferation in vitro, with the greatest increase in cell proliferation seen following exposure to human milk.

They demonstrated how ANG stimulates proliferation of myeloid progenitor cells.

«We knew that ANG was involved in promoting cell growth so it was not unexpected to find that ANG stimulates proliferation of myeloid progenitor cells,» said Guo - fu Hu, PhD, Investigator in the Molecular Oncology Research Institute at Tufts Medical Center, and the paper's senior author.

But recent evidence suggests that Nanog promotes tumor growth by stimulating the proliferation of cancer stem cells.

This, in turn, stimulates proliferation of cancer stem cells.

In a new paper, Brown University researchers show one: proliferation helps change the NK cells» function from stimulating the immune response to calming it down, lest it get out of hand.

This antibody activates an integrin on the cell surface of basal progenitors and thus stimulates their proliferation,» explains Denise Stenzel, who headed the experiments.

They also found that when under stress from chemotherapy, megakaryocytes signaled fibroblast growth factor 1 (FGF1), to stimulate the proliferation of hematopoietic stem cells.

Antibodies stimulate the recruitment of additional immune cells that help to activate T cells; the vaccine stimulates proliferation of T cells that can attack the tumor; IL - 2 helps the T cell population to expand quickly; and the anti-PD1 molecule helps T cells stay active longer.

SAP domain - dependent Mkl1 signaling stimulates proliferation and cell migration by induction of a distinct gene set indicative of poor prognosis in breast cancer patients.

Blake DA, Yu H, Young DL, Caldwell DR. Matrix stimulates the proliferation of human corneal endothelial cells in culture.

Arginine stimulates proliferation of ovine trophectoderm cells through MTOR - RPS6K - RPS6 signaling cascade and synthesis of nitric oxide and polyamines.

MSCs impair the differentiation of monocytes or CD34 + HSCs into DCs by inhibiting the response of the former to maturation signals, reducing the expression of co-stimulatory molecules and hampering the ability of the former to stimulate naive T cell proliferation and IL - 12 secretion 33, 34, 35.

IL - 17 is a potent synergistic factor with GM - CSF in mice in stimulating myelopoiesis, dendritic cell expansion, proliferation, and functional enhancement.

Insulin stimulates primary β - cell proliferation via Raf - 1 kinase.

To this end, we are focusing on two aspects of β - cell regeneration: enhancing β - cell proliferation in vivo and stimulating the differentiation of new β - cells from endogenous progenitors in the pancreas.

In contrast, proliferation differences seen between DGKζ − / − or Cbl - b − / − CD8 + T cells mostly dissipate upon administration of exogenous IL - 2, which indicates that the enhanced production of IL - 2 in stimulated Cbl - b − / − CD8 + T cells is the primary factor responsible for the observed differences between the two genotypes.

Some of those hits affect tyrosine kinases, enzymes that promote cancer by stimulating abnormal cell growth and proliferation.

The most over-expressed gene in adipose tissue of diabetic co-twins was SPP1 encoding the inflammatory cytokine osteopontin, which recruits macrophages into adipose tissue and stimulates T - cell proliferation during inflammation (34).

These abnormal cells — in the case of pulmonary hypertension, those that line the blood vessels leading to the lungs — release signals that stimulate the growth of small new blood vessels to feed the renegade cells, allowing further proliferation, and thickening of the vessel walls.

Functionally, T cells stimulated by antigen but without costimulatory signals, are able to proliferate and expand in numbers, but only transiently, with proliferation being very short - lived and few T cells being able to survive over time (Rogers, 1998, J Immunol).

Her mentor was Lindsay Shopland, Ph.D., director of education and the research topic was stimulating proliferation of primary mantel cell lymphoma cells using a combination of MegaCD40L and IL4

The addition of RA and SCF is reported to stimulate the proliferation of primordial germ cells in vitro in mice [58], [59].

Results : The application of specific optimised conditions induce multiple rounds of memory B cell proliferation equally across Ig isotypes, differentiation of memory B cells to antibody secreting cells, and importantly do not alter the Ig genotype of the stimulated cells.

Indeed, HPCs failed to stimulate allogenic T cells in proliferation assays, in contrast to splenocytes and bone marrow cells.

In mice, which are mammals like humans, MSI - 1436 improved heart function, increased survival, reduced scarring and stimulated the proliferation of heart muscle cells.

Here it stimulates fibroblasts, the cells responsible for collagen proliferation, thereby increasing the body's collagen levels and also its natural production of collagen.

16α - OH E1, also a Phase I estrone metabolite, is an estrogen agonist, stimulates cell mitosis and proliferation, and is associated with increased risk of prostate cancer.

After all, glucose fuels cancer cells, and the hormone insulin can stimulate cancer cell proliferation.

Genistein Inhibits Both Estrogen and Growth Factor — stimulated Proliferation of Human Breast Cancer Cells Cell Growth & Differentiation 1996 (Oct); 7 (10): 1345 — 1351 Genistein is a naturally occurring dietary protein tyrosine kinase (PTK) inhibitor that is hypothesized to be responsible for the lower rate of breast cancer observed in Asian women consuming soy.

Angelica Sinensis Angelica has been shown to stimulate the proliferation of precursor cells to maintain bone health.

The liberation of IL - 4 and IL - 6 stimulates satellite cell proliferation and fusion.

Greco RM, et al., «Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrix,» J Cell Physiol 177 (3): 465 - 73 (1998).

During the follicular phase, estrogen stimulates proliferation of endometrial cells.