Needless to say the second group was hyperinsulinaemic and IR; insulin
stimulates cholesterol synthesis and inhibits (re) absorption, while glucagon has the opposite effect; enterohepatic bile cycling is increased by glucagon.
I mean if you, if your diet isn't quite in check in insulin resistance going on, that will get worse over time, and insulin does drive that hemometagluteracoreboductase enzyme that
stimulates cholesterol synthesis.
Not exact matches
Thus it makes sense, and helps to keep
cholesterol in balance with requirements, that
cholesterol synthesis is
stimulated by insulin (the fed state hormone) and inhibited by glucagon (the fasting state hormone).
Insulin
stimulates hydroxy methyl glutaryl - Co-A reductase, one of the rate - limiting enzymes in
cholesterol synthesis.