The SDF - 1 / CXCR4 interaction
stimulates tyrosine phosphorylation of CXCR4, followed by the activation of multiple G protein - dependent signaling pathways, which may be different among cell types.
Twelve - hour exposure of 3T3 - L1 adipocytes to H (2) O (2) or TNF - alpha resulted in the increase of c - Jun NH (2)- terminal kinase (JNK) activation and insulin receptor substrate 1 (IRS1) serine 307
phosphorylation, concomitantly with the decrease in insulin -
stimulated IRS1
tyrosine phosphorylation and cellular glucose uptake.