C. Bass et al. «Optogenetic
stimulation of VTA dopamine neurons reveals that tonic but not phasic patterns of dopamine transmission reduce ethanol self - administration.»
Consistent with the primary role of Tie2 in survival signalling and quiescence of EC, Ang1
stimulation of BP was robustly anti-apoptotic, but had no effect on pericyte proliferation or migration (Supplementary Fig. 3).
Researchers from the RIKEN - MIT Center for Neural Circuit Genetics have found that light
stimulation of brain cells can recover memories in mice with Alzheimer's disease - like memory loss.
Optogenetic
stimulation of glutamatergic neuronal activity in the striatum enhances neurogenesis in the subventricular zone of normal and stroke mice.
Stimulation of Transforming Growth Factor - ß1 - Induced Endothelial - To - Mesenchymal Transition and Tissue Fibrosis by Endothelin - 1 (ET - 1): A Novel Profibrotic Effect of ET - 1.
Electrical
stimulation of the brain may be one alternative scientists can pursue, according to Christine Denny, a neurobiologist at Columbia University.
OBE - like experience has also been induced through
stimulation of the posterior part of the right superior temporal gyrus in a patient.
Non-Canonical Wnt Predominates in Activated Rat Hepatic Stellate Cells, Influencing HSC Survival and Paracrine
Stimulation of Kupffer Cells.
«
The stimulation of a metabolism - sensing enzyme that can regulate specific genes explains how oxidative stress, which is generated throughout the embryo during maternal hyperglycemia, causes malformation of specific embryo structures,» Loeken said.
Terence Hines (2003) has written that spontaneous out - of - body experiences can be generated by artificial
stimulation of the brain and this strongly suggests that the OBE experience is caused from «temporary, minor brain malfunctions, not by the person's spirit (or whatever) actually leaving the body.»
Blanke and his collaborators in Switzerland have explored the neural basis of OBEs by showing that they are reliably associated with lesions in the right TPJ region [113] and that they can be reliably elicited with electrical
stimulation of this region in a patient with epilepsy.
Sequence - dependent
stimulation of the mammalian innate immune response by synthetic siRNA.
In their study Loeken and her group, including Yichao Wu, Marta Viana, and Shoba Thirumangalathu, used mice and cell lines to test their hypothesis that AMPK might be stimulated in the embryo and that
stimulation of AMPK was responsible for blocking Pax3 expression and causing neural tube defects in response to high glucose.
The stimulation of HSD17B7 expression by estradiol provides a powerful feed - forward mechanism for estradiol biosynthesis in breast cancer cells.
OBE - like experiences have been induced by
stimulation of the brain.
Gozzi, A. *, Herdon, H., Schwarz, A., Bertani, S., Crestan, V., Turrini, G., Bifone, A. Pharmacological
stimulation of NMDA receptors via co-agonist site suppresses fMRI response to phencyclidine in the rat (2008) Psychopharmacology, 201 (2), pp. 273 - 284.
The protocol can be used to measure adaptive responses following
the stimulation of whole blood samples or purified peripheral blood mononuclear cells (PBMCs) and includes a freezing step that allows the stimulated samples to be shipped from the collection site to the analysis facility.
One technique induces membrane movement using the optogenetic
stimulation of neurons and captures the subsequent events at a millisecond temporal resolution using a rapid high - pressure freezing method.
Intriguingly, the team also found that children consistently slept for about 37 minutes less than health professionals thought best at the time, and that the blame was invariably put on children being «overtaxed by
the stimulation of modern living».
The theta rhythm (3 to 8 Hz) is a large EEG potential recorded from the hippocampus in rodents and humans29, 37 and is thought to aid formation of memories.37 It has been suggested that resetting of the phase of the theta rhythm improves memory performance by allowing the best possible encoding of novel stimuli.38
Stimulation of the perforant pathway in rodents induces resetting of the theta phase and produces favorable conditions for long - term potentiation.9, 39 In four subjects in our study who had contacts implanted in the entorhinal region and ipsilateral hippocampus, we observed theta - phase resetting in the hippocampus during
stimulation of the entorhinal region.
«The effects of multi-target simultaneous
stimulation of motor and cognitive networks demand investigation,» says Prof. Jeffrey Hausdorff of TAU's Sackler School of Medicine and the Center for Movement Disorders at Tel Aviv Medical Center, who led the research for the study, just published in the journal Movement Disorders.
Figure 2 shows the average of the subjects» behavioral performance during spatial learning with unilateral
stimulation of the entorhinal region or hippocampus.
In rodents, hippocampal LTP may be induced through electrical
stimulation of the perforant path.
Furthermore, repeated
stimulation of these neurons over time caused the mice to gain weight.
The authors also show that
stimulation of gray matter did not improve memory.
It proposes that transcranial direct - current electrical
stimulation of the primary motor cortex and the left dorsolateral prefrontal cortex significantly ameliorates the condition.
Bliss TV, Lomo T. Long - lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following
stimulation of the perforant path.
In the six subjects, we observed significantly shorter latency (Figure 2A) and shorter excess path length for locations that had been learned during
stimulation of the entorhinal region in blocks 1, 2, and 3, than for locations that had been learned without stimulation (latency, z = − 2.20, P = 0.03; excess path length, z = − 2.20, P = 0.03; effect size, [Cohen's] d = 1.74)(Figure 2A and 2C, respectively).
A similar approach is employed with cochlear implants for hearing loss which translate sounds into electrical
stimulation of the inner ear and, over time, the brain learns to interpret these inputs as sound.
Thus, there were six tests of retention of memory after
stimulation of the entorhinal area and six tests of retention of memory after
stimulation of the hippocampus.
Stimulation of TLR2 / TLR6 triggers profound decreases in ferroportin mRNA and protein expression in bone marrow - derived macrophages, liver and spleen of mice without changing hepcidin expression.
The few studies involving direct electrical
stimulation of the hippocampus in humans have generally shown a disruptive effect on memory.
Other optogenetic studies highlight the advantage of afferent stimulation to target downstream neuronal assemblies compared to direct
stimulation of gray matter (Gradinaru et al., 2009; Rajasethupathy et al., 2016).
Bilateral deep - brain
stimulation of the globus pallidus in primary generalized dystonia.
«Several studies suggest
stimulation of the hippocampus increases both functional activity and gray matter within this region.»
Follow - up studies will assess whether repeated
stimulation of the unaffected side of the brain can help to «teach» it to control the impaired arm, Harrington says.
Our results show that spatial learning in humans can be enhanced by electrical
stimulation of the entorhinal region, a specific site within the medial temporal lobe and the chief gateway into the hippocampus.
Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory.
A phase I trial of deep brain
stimulation of memory circuits in Alzheimer's disease.
If a significant
stimulation of 5 - HT3 expressing afferents occurs with sweet tastant stimulation, then one would expect sweet - tasting stimuli to evoke indirect side band excitation of sour - best afferent fibers.
However,
stimulation of targets in the lateral hypothalamus in rodents during learning resulted in improved performance on tests of subsequent memory.11
«The participants» walking improved after simultaneous
stimulation of the primary motor cortex and left dorsolateral prefrontal cortex, but not after primary motor cortex only or sham stimulation.
Only the precise
stimulation of engram cells was able to increase the number of spines and bring about the memory improvement in AD mice.
Stimulation of the entorhinal region enhanced memory of spatial information when applied during learning.
While elevated ozonediddecrease the Phl p 5 allergen content in pollen, «the strong CO2 -
stimulation of pollen production suggests increased exposure to Timothy grass allergen overall,» even if O3 projections are realized, the authors note.
Lacruz ME, Valentin A, Seoane JJ, Morris RG, Selway RP, Alarcon G. Single pulse electrical
stimulation of the hippocampus is sufficient to impair human episodic memory.
Intriguingly, patients receiving deep brain
stimulation of the subthalamus, which includes the ZI, for the treatment of movement disorders can exhibit characteristics of binge eating.
To determine whether phase resetting occurred in the hippocampus after
stimulation of the entorhinal region, waveforms for 5 - second periods before and during each stimulation train were averaged separately for each trial.
Animal studies have indicated that electrical
stimulation of the brain can improve recovery from stroke.
The stimulation of light on the right eye alters the developing left - brain hemisphere but not the right.