Not exact matches
In animal models, exposure to cigarette smoke or nicotine during fetal development alters the expression of the nicotinic acetylcholine receptor in areas of the brainstem important for autonomic function, 28 alters the neuronal excitability of
neurons in the nucleus tractus solitarius (a brainstem region important for sensory integration), 29 and alters fetal autonomic activity and medullary neurotransmitter receptors.30 In human infants, there are strong associations between nicotinic acetylcholine receptor and serotonin receptors in the brainstem during development.31 Prenatal exposure to tobacco smoke attenuates recovery from hypoxia in preterm infants, 32 decreases heart rate variability in preterm33 and term34 infants, and abolishes the normal relationship between heart rate and gestational age at birth.33 Moreover, infants of smoking mothers exhibit impaired arousal patterns to trigeminal
stimulation in proportion to urinary cotinine levels.35 It is important to note also that prenatal exposure to tobacco smoke alters the normal programming of cardiovascular reflexes such that there is a greater -
than - expected increase in blood pressure and heart rate in response to breathing 4 % carbon dioxide or a 60 ° head - up tilt.36 These changes in autonomic function, arousal, and cardiovascular reflexes might all increase an infant's vulnerability to SIDS.
Remarkably, stimulating these
neurons during social dominance tests one day affected the mice's performance — without any
stimulation — the next day; mice receiving more
than six photostimulated wins all maintained their new rank, whereas most mice receiving fewer
than five photostimulated wins returned to their original rank, the authors report.
«Neuronal targets to restore movement in Parkinson's disease model: By using optogenetics to control
neurons in the basal ganglia, researchers achieve effects that last longer
than deep brain
stimulation.»
Vagal
stimulation works by this parasympathetic, also called muscarinic after the psychedelic drug muscarine,
stimulation spreading up through the brain, thereby overriding the inhibitory
neurons, awakening more
than the normal 10 % brain use.