Lin began by studying substances that are able to alter or
stop cell division, called inhibitors.
«Three rings
stop cell division in plants: Development of a triarylmethane compound for possible control of plant growth.»
DNA damage inhibits CDK activity, freeing Rep - MYB and
stopping the cell division,» he says.
«We saw that chem7 had hardly any effect on the shapes of the cells and tissues, thus, suggesting that chem7
stops cell division in plant cells, but does not cause any severe damage to the shapes,» describes Ueda.
«chem7 rapidly
stops cell division and plant growth without causing drastic damage to the shapes or functions of the cells.»
Not exact matches
He and colleagues have determined what gives cholera bacteria their curved shape and whether it matters (a polymer protein, and it does matter; the curve makes it easier for cholera to cause disease), how different wavelengths of light affect movement of photosynthetic bacteria (red and green wavelengths encourage movement; blue light
stops the microbes in their tracks), how bacteria coordinate
cell division machinery and how photosynthetic bacteria's growth changes in light and dark.
The embryos lacking functional BRCA2 genes probably
stopped growing because molecular «checkpoints» in the developing embryo either halt the
division of
cells with damaged DNA, so that the damage can be repaired, or kill the
cells outright.
Without an infection, the few mutated
cells that could potentially cause cancer
stop proliferating after several
divisions.
One day, the
cell division in one of the flasks seemed to be slowing down, and after about the 40th doubling, the
cells stopped reproducing.
With each
cell division, telomeres dwindle until they are just tiny nubs, which prompt
cells to malfunction,
stop replication and finally die off.
To ascertain that they had
stopped growing permanently, the scientists waited up to 2 days after the last
cell division before trying to cultivate them.
«Now that we know exactly how changes in EMSY spur cancer
cell growth, we can start to design therapies to specifically target that activity and hopefully
stop it,» says senior author Douglas Levine, MD, director of the
Division of Gynecologic Oncology at NYU Langone and its Perlmutter Cancer Center.
But if supplies of these materials run low, the
cell will enter a suspended state called senescence and
cell division will
stop, freezing the advance of the virus, according to new findings from a Duke University research team that appear in Proceedings of the National Academy of Sciences.
The «mother»
cell appears in light blue up to the time of
division when it appears mostly green and its migration
stops completely.
However, stem
cells and some cancer
cells make enough telomerase to keep their telomeres from shortening, effectively
stopping the aging clock and allowing a seemingly unlimited number of
cell divisions.
Scientists think that normal
cells, which apparently lack the telomerase enzyme,
stop dividing and die off appropriately after 50 to 100
divisions when their telomeres are worn to the nub.
Histone deacetylase (HDAC) inhibitor therapy is a type of targeted therapy that blocks enzymes needed for
cell division and may
stop the growth of cancer
cells.
They remain alive for a time after they
stop dividing, but sometime after cellular
division ends,
cells do a particularly disturbing thing: Essentially, they commit suicide.
Introducing miR - 24 into proliferating normal and tumor
cells also
stopped them from further
cell division.
This study has demonstrated that by
stopping the supply of certain amino acids it is possible to retard cancer
cell division and growth.
Nine years of study have shown that a natural product called Ellagic acid is causing G - arrest within 48 hours (inhibiting and
stopping mitosis - cancer
cell division), and apoptosis (normal
cell death) within 72 hours, for breast, pancreas, esophageal, skin, colon and prostate cancer
cells.