A graduate student Anni Nieminen, the first author in the study explains, «In healthy cells dwindling ATP levels signals activation of AMPK, which tells the cells to save energy, for example, by
stopping the cell proliferation.
Not exact matches
When researchers suppressed the ARF gene in mole - rat
cells during the reprogramming process to iPSCs, the
cells stopped proliferation with sign of cellular senescence, while the opposite happens with mouse
cells.
«Further research is needed to characterize how we can potentially remove or block this protein to
stop the
proliferation of leukemia
cells.»
Healthy wound healing has four phases: blood clotting to
stop bleeding, inflammation to remove dead and damaged
cells,
proliferation of new tissue and the remodeling of tissues to be stronger and better organized.
The new findings showed that these analogs of pactamycin largely
stopped cancer
cell proliferation and growth, causing
cells to age and lose their ability to divide and grow.
However,
cells with active Myc can not
stop the
cell cycle engine and we think that the non-
stop proliferation of the
cells with low ATP content leads to prolonged activation of AMPK and p53.
It is also the first in an emerging class of therapies called «checkpoint blockade,» which enhance the immune system's ability to attack cancer by interfering with immunological checkpoints that slow or
stop immune
cell activation and
proliferation in the presence of tumors or chronic viral infection.
According to Vogelstein, this catalog, which its developers named the «kinome,» constitutes an ideal collection of targets for cancer researchers seeking to
stop the uncontrolled
proliferation of cancer
cells.
Once the immune system is alerted to
stop attacking the collagen type II, there seems to be a
proliferation of T - suppressor
cells.