Sentences with phrase «stopped ribosomes»

First, it stopped ribosomes from producing proteins, which slowed down the growth of the tumor.

Not exact matches

Allan Jacobson, Ph.D., of the University of Massachusetts Medical School and co-founder of PTC Therapeutics, the company that developed ataluren, and David Bedwell, Ph.D., professor of the UAB Department of Biochemistry and Molecular Genetics, have sought to understand precisely how ataluren allows the ribosome, the machinery of cellular protein synthesis, to skip over these inserted stop signs and produce proteins that have normal or near - normal function.

When the first ribosome stops, the others pile up behind it.

They made short proteins, exactly the length you'd expect if the ribosome were stopping at the damaged base.»

Instead, the signal peptide adopts a specific conformation in the presence of the antibiotic, which blocks and inhibits the active center of the ribosome, thus accounting for the premature stop.

The three combinations left over, UAG, UAA and UGA, act like a full stop or period — telling the ribosome to terminate its production process.

It makes sure that the ribosomes within cells, in which the proteins are built, start and stop reading an RNA strand at just the right points to generate a certain protein.

These are drugs — still experimental — that prevent premature stop signals from halting protein production by ribosomes, although NMD tends to limit their efficacy.

In ongoing projects, we aim to elucidate the mechanism and regulation of selenocysteine incorporation by determining how ribosomes distinguish between UGA / Sec and UGA / Stop codons, how mutations in SBP2 impact the expression of the selenoproteome, and how the hierarchy of selenoprotein synthesis is regulated in selenium deficiency.

The start and stop codons tell the ribosome where to start or stop translating and this way they define an open reading frame.