The thymus is the small organ in the lymphatic system that makes T - cells, [29] which are highly specialized immune cells that target specific types and
strains of microbes, like viruses.
He and his colleagues found several
strains of microbes in certain children's feces that seemed to protect them from developing the chronic inflammatory disease.
In the laboratory they isolated 221
strains of microbes from the diseased samples and picked out the four most prevalent organisms.
They studied samples of rumen gut contents from 43 cows and identified 913 diverse
strains of microbes living in the rumen.
To determine the importance of the enzyme to the bacteria's ability to set up shop in the stomach, the team disabled the enzyme in one
strain of microbe.
The researchers found a number of different
strains of the microbe, including 66 that had never been identified before.
We've already worked out the theory of how we could target
a strain of microbes in a natural microbiome.
In the future, they would like to target
a strain of microbes in other microbiomes, such as those found in soil or water.
A recent study conducted by researchers from Stanford School of Medicine in the U.S. revealed that certain
strain of microbes living in the intestines of mice raised on diets comparable to those of first world country citizens were at risk of extinction.
Not exact matches
Actually, that's only half her job, which is to ensure that outgoing missions to places that might be capable
of harboring life don't get contaminated with Earth
microbes, and to ensure that any missions to far - off places don't bring back the real - life version
of the Andromeda
strain.
Huge successes in the isolation and cultivation
of marine microbial
strains have been made by the EC - funded MaCuMBA (Marine Microorganisms: Cultivation Methods for Improving their Biotechnological Applications) project, which aims to uncover the untold diversity
of marine
microbes using cultivation - dependent strategies.
Unlike antibiotics, which act like sledgehammers, wiping out all bacteria, phages specifically target single
strains of these germs, leaving beneficial
microbes unharmed.
The study
of the new
strain's genetic structure might also lead researchers to a better understanding
of how the
microbe adapts itself to human hosts.
The authors caution that while humans and dogs host very similar
microbes, they are not exactly the same
microbes, but very closely related
strains of the same species.
New pandemics are most likely to be triggered by mutant
strains of familiar
microbe species, especially those that have caused plagues by churning out mutant
strains in the past.
Genetic assays can pinpoint particularly dangerous
strains of otherwise mild
microbes.
The two types
of microbes mixed in these migrants, creating today's European
strain much more recently than expected.
But it wasn't just any gut
microbe — this early farmer was infected with a particular ancient
strain of Helicobacter pylori bacteria that is most similar to modern Asian
strains.
Then, they examined the bacterial DNA, looking for patterns or variations in the
microbes» genes that would help them identify specific
strains of bacteria.
The team suggests that further studies
of strain differences could lead to probiotic treatments for acne, which instead boost or supply beneficial
microbes.
The findings, which appear in the March 11 issue
of Cell Host &
Microbe, contradict previous reports from Indian health officials that the
strain has not changed from the version
of H1N1 that emerged in 2009 and has been circulating around the world ever since.
Although bacteria have a seemingly limitless capacity to alter their genes by swapping bits
of DNA between
strains, this mechanism doesn't seem enough to account for the swift pace
of change and the high variability
of E. coli and other
strains.Thomas Cebula
of the U.S. Food and Drug Administration (FDA) wondered if this rapid evolution is being driven by
microbes capable
of much faster - than - normal variation.
By isolating five bacterial
strains of endophytes found inside S. halepense rhizomes (subterranean stems used for storage and vegetative reproduction) and growing them in the lab in different mixtures
of substrates, the authors determined that these
microbes were able to fix and mobilize nitrogen, phosphorus, and iron.
The researchers modified an ordinary laboratory
strain of the ubiquitous human gut
microbe Escherichia coli, enabling the bacteria to not only record their interactions with the environment but also time - stamp the events.
Compared to healthy people, ICU patients had depleted populations
of commensal, health - promoting
microbes and higher counts
of bacterial taxa with pathogenic
strains — leaving patients vulnerable to hospital - acquired infections that may lead to sepsis, organ failure and potentially death.
After growing several hundred
strains of common
microbes, they determined that the most effective was a soil
microbe called Bacillus licheniformis.
They restored symptoms simply by cohousing their mice with a microbially richer
strain, suggesting that the traits they had come to rely on in their research hinged on a delicate balance
of mouse
microbes.
Ground - breaking research has found that introducing «friendlier» less - potent
strains into a population
of disease - causing
microbes can lead to increased disease severity.
The team injected different
strains of Bacteroides fragilis, the species
of gut - dwelling bacteria (pictured here), into mice that lacked their own
microbes.
In the case
of opiatemaking yeast, such rules might forbid developing
strains to produce illicit drugs, such as heroin, and require scientists to build in genes that prevent the
microbes from living outside
of a controlled laboratory environment.
When they used an ampicillin - resistant
strain of E. coli, however, they found that the oscillations initially decreased but returned to normal within about 15 minutes, indicating that the
microbes had recovered.
They then split each
of these two
strains into three groups and to each group added genes for one
of three different metabolic pathways that allow the
microbes to make chemical precursors for either gasoline, diesel, or jet fuel.
Now researchers report that they've found a new
strain of methane - eating
microbes in soil samples from Axel Heiberg Island, in the Canadian high Arctic.
Using a genetically altered
strain of Toxoplasma that is not able to form cysts and thus is unable to cause chronic infections in the brain, she demonstrated that the effect persisted for four months even after the mice completely cleared the
microbe from their bodies.
To see what role the body's own immune system played in fighting infection, compared with gut
microbes, the team also studied two
strains of mice that have impaired immune systems.
The researchers found that bacteria forming part
of a cluster were more likely to be taken up by human cells and to survive in them than the
microbes without close relatives; the cluster
strains also caused more severe disease in mice.
It shows once more that using metagenomics can be remarkably effective in tracking the evolution and spread
of microbes without the need for culture — in this case, metagenomes revealed that some
strain lineages have been circulating in Europe for more than two centuries.»
For this reason, it is important to determine not only the types
of microbes present in a given sample, but also the genetic makeup
of each
strain.
And while scientists have made strides in recognizing various
strains of gut
microbes by identifying their molecular DNA signature, they still have a long way to go to determine what each does and how each functions, Bienenstock says.
For many
microbes, the expansion
of growing cell groups toward a source
of limiting nutrients tends to promote the spontaneous segregation
of different
strains due to genetic drift along the advancing group front [36].
The Joslin researchers bred new generations
of the three mice models and then tested whether germ - free mice who were given
microbes from these three
strains of mice were prone to diabetes or obesity like the donors.
The
microbe is one
of the first K. pneumoniae
strains reported to the CDC that was resistant to all 26 antibiotics available for treatment, says Tom de Man, a bioinformatics expert at the CDC who led the study.
The
microbe has also been used to create transgenic crops, including new
strains of corn and soybeans.
Our research will contribute to a better mechanistic understanding
of the
microbes that live in our body, leading to the discovery
of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial
strains that can be employed for intervention therapies.
And, these genes are not random or trivial; they often have huge implications for disease and are involved in critical processes, like determining which proteins a
microbe produces or changing a
strain of bacteria from being safe to harmful.
Probiotics / prebiotics / antibiotics Effect
of a yoghurt drink containing Lactobacillus
strains on bacterial vaginosis in women — a double - blind, randomised, controlled clinical pilot trial — C. Laue — Beneficial
Microbes
Home scientists arguably lack the tools to stumble upon a new
strain of influenza or accidentally create a deadly bioweapon, but they are apt to overlook fundamental laboratory safety measures that are important even when working with seemingly benign
microbes.
Our research will contribute to a better mechanistic understanding
of the
microbes that live in our gut, leading to the discovery
of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial
strains that can be employed for intervention therapies.
One
of the many problems with formula is the glaring omission
of these
microbes leaving the baby susceptible to colonization by inappropriate
strains, suboptimal diversity, and stimulation
of the immune system by many
of the toxic compounds in this synthetic food.
In one study, researchers fed probiotics —
strains of good bacteria — to mice and suggested the resulting changes in the gut's
microbe colonies could ease feelings
of anxiety.