Sentences with phrase «stranded rna»

He next conducted post-doctoral research on the molecular biology of negative stranded RNA viruses, mainly influenza A and B viruses, under the supervision of Dr. Adolfo Garcia - Sastre in the Department of Microbiology at the Icahn School of Medicine at Mount Sinai in New York, USA.

His research interest has been focused on the molecular biology, virus - host interaction and pathogenesis of positive - and negative - stranded RNA viruses.

Images from the Marburg virus reveal the VP35 protein spirals around the double - stranded RNA, enveloping it completely.

I was intrigued and perplexed by the paper: how could a double - stranded RNA possibly silence gene expression?

They are also partially defective in response to double - stranded RNA.

When a single - stranded RNA matches the guide RNA's sequence, Argonaute cleaves the targeted RNA, thereby preventing it from serving as a template for protein production.

Dicer recognizes double - stranded RNA (dsRNA), latches onto it, and chops it into pieces 21 - 23 nucleotides long.

The new research describes how the VP35 protein of the Marburg virus binds to the viral double - stranded RNA and hides it to prevent the alarm from being sounded.

These results indicate that the signaling pathways for the two types of IFN and double - stranded RNA share common components or that their function depends on common enzymes or transcription factors.

New work from the Ollmann Saphire lab shows the Marburg virus VP35 protein (beige) surrounds the virus's double - stranded RNA (blue), masking it from immune system detection.

A mutant cell line defective in response to double - stranded RNA and in regulating basal expression of interferon - stimulated genes

Double - Stranded RNA - Binding Protein 4 Is Required for Resistance Signaling against Viral and Bacterial Pathogens

Abbreviations: ASC, apoptosis - associated speck - like protein containing a caspase - recruitment domain; ATM, adipose - tissue - resident macrophage; BAT, brown adipose tissue; CCR2, CC chemokine receptor 2; CHOP, C / EBP (CCAAT / enhancer - binding protein)- homologous protein; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; ER, endoplasmic reticulum; GPCR, G - protein - coupled receptor; HIF, hypoxia - inducible factor; IFNγ, interferon γ; IKK, inhibitor of nuclear factor κB kinase; IL, interleukin; IRS - 1, insulin receptor substrate - 1; JNK, c - Jun N - terminal kinase; LDL, low - density lipoprotein; Ldlr, LDL receptor; LXR, liver X receptor; MCP - 1, monocyte chemoattractant protein 1; miRNA, microRNA; mTOR, mammalian target of rapamycin; NAFLD, non-alcoholic fatty liver disease; NF - κB, nuclear factor κB; NLRP3, NLR (nucleotide - binding - domain - and leucine - rich - repeat - containing) family, pyrin - domain - containing 3; oxLDL, oxidized LDL; PKR, double - stranded RNA - dependent protein kinase; PPAR, peroxisome - proliferator - activated receptor; STAT6, signal transducer and activator of transcription 6; SVF, stromal vascular fraction; TLR, Toll - like receptor; TNFα, tumour necrosis factor α; UPR, unfolded protein response; WAT, white adipose tissue

microRNAs (miRNA)-- small, hairpin - like structures of single - stranded RNA molecules that can regulate the expression of protein - coding genes.

Tao later solved the structure for the capsid protein coat of a fungal double - stranded RNA virus.

The results of Reinisch's monumental effort were published in Nature in 2000 and provided novel insights about how double - stranded RNA viruses make and deliver viral messenger RNA into the host cell.

In other experimental work, Pyle recently solved the crystal structure of a complex of double - stranded RNA and RIG - I, an intracellular receptor that recognizes viral RNAs and triggers an anti-viral response.

Newer, better and safer techniques are always welcome and the announcement of «single - stranded RNA» silencing is causing quite a hubbub.

The virus was identified as an enveloped positive - stranded RNA virus with a size of approximately 55 nm in diameter.

These structures gave Peersen insight into how these single - stranded RNA viruses work.

Work by scientists in 1998 unexpectedly showed that double - stranded RNA molecules could suppress the translation of messenger RNA (mRNA) into protein.

To block all miRNA formation in zebrafish, we generated maternal - zygotic dicer (MZdicer) mutants that disrupt the Dicer ribonuclease III and double - stranded RNA - binding domains.

The double - stranded RNA spreads through all cell types and shuts off the targeted gene.

Basically it involves delivering small, 20 - base pieces of double - stranded RNA into a cell that, once inside, will anneal to pieces of RNA that have complementary sequences.

TDP - 1, the Caenorhabditis elegans ortholog of TDP - 43, limits the accumulation of double - stranded RNA.

DNA binding of centromere protein C (CENPC) is stabilized by single - stranded RNA.

The RNA helicase RIG - I has an essential function in double - stranded RNA - induced innate antiviral responses.

The roles of two IκB kinase - related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection.

Although African maize is infected by several virus species from at least six different families, there are two that stand out as the greatest threat to African food security: these are Maize streak virus [MSV]; family Geminiviridae, a virus species with an extremely small single - stranded DNA genome that was first discovered infecting African maize over a century ago; and Maize rough dwarf virus [MRDV], family Reoviridae, a virus species with a complex double - stranded RNA genome that until recently was thought to occur only in Europe and Asia.

Species - specific recognition of single - stranded RNA via Toll - like receptor 7 and 8.

Upregulation of costimulatory molecules induced by lipopolysaccharide and double - stranded RNA occurs by Trif - dependent and Trif - independent pathways.

Selective contribution of IFN - α / β signaling to the maturation of dendritic cells induced by double - stranded RNA or viral infection.

Weaver, B. K., Kumar, K. P. & Reich, N. C. Interferon regulatory factor 3 and CREB - binding protein / p300 are subunits of double - stranded RNA - activated transcription factor DRAF1.

Examples include terminally mannosylated and polymannosylated compounds (which bind the mannose receptor) and various microbial components, such as bacterial lipopolysaccharide, hypomethylated DNA, flagellin and double - stranded RNA (all of which bind Toll - like receptors).

This domain can unwind double - stranded RNA using energy derived from the hydrolysis of ATP.

Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7 - mediated recognition of single - stranded RNA.

One type of RNA editing involves the conversion of adenosine residues into inosine specifically in double - stranded RNA (dsRNA).

The virus, a member of the virus family Arenaviridae, is a single - stranded RNA virus and is zoonotic, or animal - borne.

It springs to life in the presence of double - stranded RNA, which often accompanies invasion of the cell by a virus.

Peter and his team discovered sequences in the human genome that when converted into small double - stranded RNA molecules trigger what they believe to be an ancient kill switch in cells to prevent cancer.

In RNAi, double - stranded RNA molecules target a messenger RNA with a corresponding sequence and cause it to be chewed up, thus preventing the messenger RNA from making its protein.

siRNAs are designed by taking short sequences of the gene to be targeted and converting them into double - stranded RNA.

But so far, silencing genes using RNAi has not worked well in mammalian cells; although the approach has been successful in mouse embryos, double - stranded RNA shuts down synthesis of all proteins, not just the target gene, in other types of mammalian cells.

Double - stranded RNA can silence the expression of a gene with a corresponding sequence, a process called RNA interference (RNAi).

A few years ago, researchers discovered that putting double - stranded RNA into a cell prompted the cell to produce enzymes that destroyed any single - stranded RNAs that matched the sequence of the double - stranded RNA.

TLR3's only job is to act as an antenna, sensing double - stranded RNA specific to viruses.

To find out more about how RNAi works, a team led by biochemist Scott Hammond of Cold Spring Harbor Laboratory in New York picked double - stranded RNA known to interfere with a gene involved in promoting cell division.

They also tested double - stranded RNA that matched a marker gene that they put into the fruit fly genome.

They had noticed that if they added double - stranded RNA to an organism, it somehow broke down any matching messenger RNA, muting the gene whose instructions are carried by that mRNA.

Their biochemical experiments revealed that fruit flies have a protein complex that attacks and destroys the mRNA that matches the double - stranded RNA.