Sentences with phrase «stranded helix»

Every time one of your cells divides, it exposes its most essential component to great danger: its genome, the sum total of all its genetic information, embodied in the double - stranded helix of DNA.

Most of the DNA in a cell is in the form of a double - stranded helix, so this is not necessarily a problem for gene - editing applications.

Ensconced in his basement, he heated Beatrice's white blood cells in his thermocycler until the double - stranded helix of her DNA unwound, leaving single strands in its place.

In America, for the first time, Christianity and democratic self - government launched themselves together in a kind of double - stranded helix spiraling through time.

RNA, or ribonucleic acid, is very similar to DNA except that it is happy to live in a single - stranded state (as opposed to DNA's desire to form complementary double - stranded helixes).

Not exact matches

The sudden heating would cause a double helix to separate into single strands.

The result is a flat surface made from a long double helix, comprised of the single long strand and more than 200 shorter strands stuck along its length, «stapling» it together at key locations.

The chromosomes here were isolated from cells, heated until each DNA double helix unzipped into two complementary strands, and then mixed with previously prepared, tagged DNA fragments.

When the helix unzips, a polymerase molecule continuously slides down one strand (called the leading strand).

Now it appears that all DNA is not recreated equal — one strand of the helix is copied more reliably than the other, according to a report in the current Proceedings of the National Academy of Sciences.

In the double - helix configuration, two strands of DNA are joined to each other by hydrogen bonds in an arrangement known as base pairing.

«Squeezing life from DNA's double helix: Recipe for replication: Two DNA strands, one ring of proteins.

In describing the two - stranded structure of DNA, Cambridge University biologists James Watson and Francis Crick gave us the image of a twisting ladder they called a double helix.

«Cas9 opens up the DNA, it separates the strands of the double helix in a very small area, and allows the guide RNA to pair with one of the strands,» explains Dana Carroll, a professor of biochemistry at the University of Utah.

For years, scientists have puzzled over what prompts the intertwined double - helix DNA to open its two strands and then start replication.

Chen said the images revealed that the proteins which surrounded the DNA had attached to it, then tightened like a vice until the bonds between the two strands of the double helix broke — or melted — the origin DNA.

When the guide - RNA locates its target DNA, it latches on, and then Cas9 cleaves through both strands of the DNA double helix.

The discovery of the structure of DNA in 1953 immediately suggested a simple mechanism for DNA replication: the two strands of the helix could unzip and allow enzymes to enter and synthesise two new strands.

The most prominent candidate to emerge from their search was Topoisomerase II, an enzyme known to cut and untwist tangled strands of the double helix.

Second, they separated the complementary strands of DNA in these fragments before sequencing so they could still use one half of the double helix even if the other half were damaged.

The model shows the classic double helix of DNA strands going in opposite directions with nucleotides linking to each other across the strands to form base pairs.

In my notebook, I drew something akin to the double helix, the double - stranded spiral of DNA.

The twisted strands are then wound together in a spiral shape called a helix, whi

NER involves several steps — the first is to recognise when one strand of a double - helix DNA molecule is damaged.

The next job is to unwind the DNA helix and cut out the offending portion from the damaged strand.

Cas9, an enzyme that acts as molecular scissors, snips both strands of the DNA double helix, which can ultimately disable a gene.

Agata Smogorzewska, head of the Laboratory of Genome Maintenance, wants to understand how cells repair interstrand cross-links, a particular type of DNA damage in which the two strands of the double helix that normally twine about each other become physically linked.

The Atlantic cod genome consists of approximately 700 million pairs of DNA bases (remember that the DNA molecule is a double helix with matching base pairs on each strand).

They have also had several clues that the proteins are involved in DNA repair: They consort with known repair proteins, and mutant versions make cells virtually unable to repair DNA when both strands of the double helix are broken.

It contains three binding sites for single - stranded DNA and has a so - called tower domain: a bundle of helices that resembles the structures other organisms use to bind double - stranded DNA.

Compared to the way two matching strands of DNA twist into a graceful helix, RNA is a mess.

This nanoscale construction approach takes advantage of two key characteristics of the DNA molecule: the twisted - ladder double helix shape, and the natural tendency of strands with complementary bases (the A, T, G, and C letters of the genetic code) to pair up in a precise way.

In a new twist on the use of DNA in nanoscale construction, scientists at the U.S. Department of Energy's (DOE) Brookhaven National Laboratory and collaborators put synthetic strands of the biological material to work in two ways: They used ropelike configurations of the DNA double helix to form a rigid geometrical framework, and added dangling pieces of single - stranded DNA to glue nanoparticles in place.

To make it possible to «glue» nanoparticles to the 3D frames, the scientists engineered each of the original six - helix bundles to have one helix with an extra single - stranded piece of DNA sticking out from both ends.

In the conventional picture, only one of the twin strands that make up the DNA double helix — the so - called «sense» strand — is copied into a single strand of messenger RNA (mRNA).

The resulting five - strand junction, in which a short helix forms base triples with three separate strands in the Tetrahymena intron, reveals exceptionally dense packing of RNA.

In both cases, the idea is to target an enzyme that cuts both strands of the double helix at a specific site.

Like the newer gene - editing technology CRISPR, ZFNs can cut both strands of the genome's double DNA helix at a specific location.

In other words, DNA polymerase splits the double helix and creates a new double helix along each of the two strands.

Instead of using double - stranded DNA to make genetic libraries that can be fed into a next - gen sequencer, as was standard practice at the time, Meyer and his team first separated the double helix, then prepared the sequence library using each of the single strands, doubling the amount of fragments the group had to sequence.

Another of the lab's achievements is its success in explaining how a six - sided protein ring called helicase — essential in all life — attaches to the double helix and works like a tiny motor, unzipping the two DNA strands as other molecular machines go about copying one of them.

When DNA is replicated, the double helix is pulled apart into two individual strands.

The bacterium has an enzyme, called Cas9, that can read that likeness, scout the environment for anything looking the same, and then, when finding a likely suspect, snip lengthwise the entwined double - helix DNA strands of the invader.

Two complementary strands of DNA base pair to form the famous double helix.

It is made up of sequences of the four base pairs A, T, C, and G. Two complementary strands of DNA are attracted to each other to form the famous double helix shape.

As DNA replicates, it has moments in which single strands of its double helix are exposed.

«In the knot structure, C letters on the same strand of DNA bind to each other — so this is very different from a double helix, where «letters» on opposite strands recognise each other, and where Cs bind to Gs [guanines].»

For the mutations located in the JH1 kinase domain, we took advantage of the recently solved crystal structure of the JAK1 JH1 domain to detail their localization.21 As shown in Figure 1C, D and E, from 13 JH1 - located mutations, 3 (K1026E, Y1035C and S1043I) are located in the activation loop (A-loop), 4 mutations affect the same residue (F958V, F958C, F958S, F958L) in the hinge region of the kinase domain at the entry of the ATP - binding pocket, 3 others (D895H, E897K and T901R) are located at the top of the kinase domain in the loop formed between two antiparallel β - strands (β2 and β3) and one mutation affects the loop formed between the β - strand - 3 (β3) and the αC helix of the JH1 domain (L910Q).

The double strand breaks are created either by site - specific designer zinc finger endonucleases or triple helix forming oligonucleotides that are able to recognise and induce repair of specific mutations in the genome.

Each strand in a DNA double - helix is negatively charged.