The skin and other
stratified epithelia as model tissues display a high turnover rate, and contain well - defined populations of adult stem cells (SCs).
After analysing the presence of NANOG in different mouse tissues by immunohistochemistry, the CNIO team demonstrated that, in addition to being present in embryonic tissue, this factor is also found in
stratified epithelia such as the esophagus, skin or vagina.
The authors of the work also show that NANOG is increased in patient - derived tumour samples from
stratified epithelia.
Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene for embryonic stem cells, also regulates cell division in
stratified epithelia — those that form part of the epidermis of the skin or cover the esophagus or the vagina — in adult organisms.
Not exact matches
Type I mucosal surfaces line the upper rectum and consist of a single layer of tightly joined, simple columnar
epithelium, while type II mucosal surfaces line the lower rectum and anus and consist of multiple layers of
stratified squamous
epithelium.
Anatomically, the mucosa of the head and neck can be divided into a layer of
stratified squamous
epithelium and an underlying connective tissue layer known as the lamina propria (Table 2).
The ΔN isoforms of p63 may also serve as stem cell markers in a variety of epithelial cell types, including endometrium [30], cervix [31], breast [32], prostate [33], and in
stratified squamous
epithelium [21,34].