Sentences with phrase «striatal neurons»
Striatal neurons are a type of brain cells found in a specific part of the brain called the striatum. These neurons play a crucial role in controlling movements and actions. They receive messages from other parts of the brain and release chemicals called neurotransmitters, which help coordinate and regulate various motor functions in our body. Full definition
Increasing RCS phosphorylation blocked GPCR - and PP2B - mediated suppression of L - type Ca2 + currents in striatal neurons.
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In Huntington's disease, mice carrying the pathologic genetic variant of the huntingtin gene are being used to understand how this genetic lesion causes degeneration of striatal neurons and to develop novel treatments for the illness.
The OIST researchers had previously shown that culturing cortical and striatal cells within the same compartment resulted in an artificial connectomic system as these cortical and striatal neurons grew connections in all directions in a disorganized manner.
When the axons reaching across the divide were cut with a knife, the interconnectivity between the cortical neurons inside their own compartment was relatively unaffected, whereas the striatal neurons showed no electrophysiological activity.
Cell therapy, as envisaged by the teams of I - Stem, is primarily based on the identification of experimental protocols that can specifically guide differentiation of pluripotent cells to a cell fate, which presents a interest for the replacement of the defective cell population from the patient (the striatal neurons for Huntington's disease, the cells of the retinal pigment epithelium for retinitis pigmentosa, keratinocytes for genodermatoses, etc.).
We develop protocols, vector and lines to challenge HD genetic determinant in selected relevant cell populations (cortical or striatal neurons, astrocytes) alone or integrated within in vitro neuronal network in microfluidic chambers.
And when they tracked the striatal neurons carrying the mutant huntingtin over time, they found them much more likely to die than those from other brain regions.
The research team found that striatal neurons were particularly sensitive to disruptions to the autophagy process.
With regard to cell therapy, we use three types of protocols for efficiently producing epidermis, striatal neurons and retinal pigmented epithelium.