Therefore, researchers from the CNIO's Experimental Oncology Group have focused their work on identifying
a stromal cell population that fosters tumour growth, to later discover why they have this capacity and reverse it.
Here we show that an abundant
stromal cell population, cancer - associated fibroblasts (CAFs), promote cancer cell invasion through the BM.
Not exact matches
To determine whether adipose tissue macrophages express any molecules implicated in obesity - associated complications, we isolated three
cell populations from the parametrial adipose tissue of three obese B6.V Lepob / ob mice: (a) an adipocyte - enriched
population, (b) a
stromal vascular macrophage F4 / 80 +
population, and (c) an F4 / 80 —
stromal vascular
population.
As part of this global aim we have demonstrated that one of the most abundant
stromal populations, the cancer associated fibroblasts (CAFs), can sample and present tumour antigen to T
cells in an antigen specific - antigen dependent manner resulting in T
cell deletion.
The tumor microenvironment is comprised of heterogeneous
populations of
cells including cancer, immune and tumor associated
stromal cells.
Stromal -
cell populations were sorted by FACSAria (BD Biosciences).