Not exact matches
The lab has shown that when NMDAR function is impaired by a genetic mutation, they can recreate, in the mouse, the
structural, neurochemical, and functional
alterations in the
brain that are characteristic of schizophrenia — for example, cognitive and memory impairments for which there are currently no effective treatments.
These abnormalities coexist with mitochondrial
structural alteration and mitochondrial DNA overproliferation and / or deletion in all
brain cellular compartments.
In both meta - analysis of
structural and functional
brain alterations in adolescents with AB versus controls, no studies providing results based on a priori region - of - interest analysis only were included (since they violate the assumption, under the null hypothesis, that the likelihood of locating activated foci is equal at every voxel).
Structural and functional
alterations in a variety of
brain regions have been associated with depression and risk for depression across the life span.