An operon is a cluster of
structural genes found in bacteria that are expressed and regulated as a unit.
Not exact matches
«This
structural «footprint» we
found seems to help these viruses get efficiently into the brain, which informs the design of potentially safer brain - targeted
gene therapies,» said study senior author Aravind Asokan, PhD, associate professor of genetics.
The study also
found «enormous
structural variation,» including missing or extra copies of cancer
genes, says Spellman, leading to over - or underexpression of proteins that might drive cancer growth.
They
found that
structural changes crank up the output of one of the
genes by 50-fold, suggesting how such flies attain increased nicotine resistance.
Song explained the
structural knowledge of DNMT3A will allow scientists to control DNA methylation content,
gene expression, and cell differentiation — all of which are linked to diseases and
finding cures for them.
For each of these three
genes, the researchers
found multiple variants that differed in
structural ways, such as whether or not they contained an extra sequence of DNA.
Overall, based on homology and
structural evidence alone, we
find evidence for 34 AMPs in the OGSv2
gene set.
Our
structural annotation (
gene finding) strategy involved masking repetitive DNA sequences, followed by a combination of EST and protein alignments, trained
gene prediction algorithms, and evidence - based
gene predictions.
«Scientists can now, at the click of a button and at a single online location, rapidly identify the biological and
structural characteristics of an actual or potential drug target,
find the
genes and proteins that it interacts with, assess its
structural druggability and identify any small molecule chemical inhibitors.
By analyzing genome sequence data from human populations, including 1269 individuals from sub-Saharan Africa, we identify a diverse array of large copy number variants affecting the host invasion receptor
genes GYPA and GYPB We
find that a nearby association with severe malaria is explained by a complex
structural rearrangement involving the loss of GYPB and gain of two GYPB - A hybrid
genes, which encode a serologically distinct blood group antigen known as Dantu.
«The
findings suggest these
genes are inactivated or deregulated more frequently than suggested by simply analyzing
structural changes in the genome,» Mullighan said.
The Brunner et al. study is the only one to report
findings of a relationship between a point mutation in the
structural gene for MAOA and aggression, which makes the
findings rare.
In their study they
found a point mutation in the
structural gene for monoamine oxidase A (MAOA), a neurochemical in the brain, which they associated with aggressive criminal behavior among a number of males in that family (Alper, 1995).