For the past decade or so, they have been exposing a nested hierarchy
of structural motifs in genomes that are every bit as elemental to the identity and activity of each cell as the double helix.
Hence AMPA and NMDA receptor channels contain common
structural motifs in their TM2 segments that are responsible for some of their ion selectivity and conductance properties.
It's a devastating defense because it's so general, targeting the
common structural motif in all of the many beta - lactam antibiotics.
«And because many amino acids, natural products, and pharmaceuticals contain the alkyl carboxylic
acid structural motif, our method can be used to rapidly functionalize these molecules,» says Hu.
The red -
colored structural motifs designate the novel functionalities introduced into the epothilone B molecule that led to their enhanced properties as cancer - fighting agents.
«The
other structural motif, the so - called side chain with a basic nitrogen embedded at a strategic position, was achieved through new extensions and improvements developed in our laboratories of the previously known HWE (Horner - Wadsworth - Emmons) reaction,» Nicolaou said.
«The most
important structural motif we introduced in these new molecules is the three - membered ring containing a nitrogen atom, a so - called aziridine moiety.»
It greatly hinders their ability to reproduce by cell division, and so chemists have for years spent time making molecules that all contain the beta -
lactam structural motif, but differ in the surrounding molecular «shrubbery.»
This recovered bismuth sample has a rhombohedral structure and contains
liquid structural motifs after deep melting at high pressures.
Our general approach has been to make use of
structural motifs found in native proteins that are predisposed to interact with a particular binding geometry, and then further bolster these anchor points with favourable hydrophobic contacts.
Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with
repeated structural motifs and possible involvement in signal transduction.
Then the abstract piece is a
very structural motif, almost mathematical, that is made up of a grid overlaid with layers of flat colour in block like shapes and is playing off the structure and colour in the other small painting.
When bismuth is brought to a liquid state under between 14,000 and 24,000 times normal atmospheric pressure (1.4 to 2.4 gigapascals) and at about 1,800 degrees Fahrenheit (1,250 kelvin), and is then slowly cooled back to a solid state, the solid «remembers» some of
the structural motifs of its liquid predecessor.
A structural motif that can bind DNA.
Rather, they simply provide
a structural motif.