Scientists hope that free - electron lasers will become the next - generation x-ray source for a range of research problemsfrom probing
the structure of single proteins to studying so - called warm, dense matter.
Not exact matches
A: I'm working on using solid - state defects in diamonds as magnetic field sensors, with the goal
of using them as little nanoscale MRI machines that can study the
structure and dynamics
of single biological molecules (e.g.,
proteins).
RAD52 works by forming a large ring
structure that binds to
single strands
of DNA, and similar to many other DNA - binding
proteins, it lacks enzymatic activity.
«What's critical with this and what has never been done before is that a
single peptide sequence will work against the toxic versions
of a number
of different amyloid
proteins and peptides, regardless
of their amino acid sequence or the normal 3 - D
structures.»
A high - resolution map
of the human cell has been generated — part
of the Human
Protein Atlas database — that provides the in situ localization
of 12,036 human
proteins at a
single - cell level, covering 30 subcellular
structures, and enabling 14 major organelle proteomes to be defined.
When the researchers looked more closely at the
structure of the human enzymes, they saw something unusual: many
single polypeptide (
protein) chains actually contained two enzymes, one
of which was embedded in the other.
This pair
of «ribbon diagram» images compares the three - dimensional
structures of two closely related
proteins, determined by X-ray crystallography: (L) the HAP2
protein from the
single - celled alga Chlamydomonas reinhardtii and (R) the fusion
protein from dengue virus.
The
structure reveals how the many
single Aβ
protein molecules are staggered in layers on top
of each other and are arranged into so - called protofilaments.
Now, they've demonstrated that a
single amino acid — known by its number along the
protein chain, 139 — is the key to this prion
protein variant adopting a «human - like» versus a «hamster - like»
structure, while another amino acid, 112, governs the structural differences between the human and mouse versions
of the
protein.
Christopher Jaroniec, professor
of chemistry and biochemistry at The Ohio State University, said that the findings highlight the fact that minor alterations in
single amino acids can cause profound differences in
structure and function among this family
of proteins.
Biologists, biochemists and geneticists who need to visualize the anatomical location
of cellular
structure,
proteins / enzymes, mRNA, and reporter genes within whole tissue are among those who can benefit from this innovative product, which can be used with light microscopy, fluorescence microscopy, confocal microscopy and
single / multiphoton microscopy.
Professor Gunnar von Heijne at Stockholm University / SciLifeLab received SEK 31 000 000 for a five - year project called»
Single - particle cryo - EM studies
of membrane
protein biogenesis and
structure».
A rare, premature aging disease, Hutchinson - Gilford progeria is caused by a
single point mutation in the gene encoding lamin A, which forms a
protein scaffold on the inner edge
of the nucleus that helps maintain chromatin
structure and organize nuclear processes such as RNA and DNA synthesis.
Turning their attention to the
single - cell level, they mapped more than 12,000
proteins to 30 subcellular
structures, in turn defining the proteomes — the complete sets
of expressed
proteins —
of more than a dozen major organelles.
microRNAs (miRNA)-- small, hairpin - like
structures of single - stranded RNA molecules that can regulate the expression
of protein - coding genes.
May 18, 2011 Errors in
protein structure sparked evolution
of biological complexity Over four billion years
of evolution, plants and animals grew far more complex than their
single - celled ancestors.
He applied
single - particle negative - stain EM to obtain the first low - resolution
structures of a GPCR / G
protein complex in different conformations and to help identify the conditions that eventually led to the X-ray
structure determination
of the complex.
NCBI provides Gene, Online Mendelian Inheritance in Man, the Molecular Modeling Database (3D
protein structures), dbSNP (a database
of single - nucleotide polymorphisms), the Reference Sequence Collection, a map
of the human genome, and a taxonomy browser, and coordinates with the National Cancer Institute to provide the Cancer Genome Anatomy Project.
Whey
Protein is not a
single element as it is a complex
structure made up
of several sub fractions.