Sentences with phrase «structure of an amyloid protein»

The researchers built a protein structure, called «alpha sheet,» that complements the toxic structure of amyloid proteins that they discovered in computer simulations.

The molecular structure of an amyloid protein can be only slightly different from a normal protein and can transform to a toxic state fairly easily, which is why amyloid diseases are so prevalent.

Not exact matches

An analysis of the peptide's structure in semen indicated that it hooked up with similar fragments to create amyloid fibers (clusters of protein fragments that have also been implicated in diseases such as Alzheimer's).

Armed with a precise knowledge of the atomic structure of the amyloid - beta protein, Jiang, Eisenberg and colleagues conducted a computational screening of 18,000 compounds in search of those most likely to bind tightly and effectively to the protein.

An amyloid fibril is a large structure consisting of misfolded proteins.

We see manifold applications, such as studies of conformational changes in amyloid structures on the molecular level, the mapping of nanoscale protein modifications in biomedical tissue or the label - free mapping of membrane proteins.

«What's critical with this and what has never been done before is that a single peptide sequence will work against the toxic versions of a number of different amyloid proteins and peptides, regardless of their amino acid sequence or the normal 3 - D structures.»

In close collaboration with his TUM colleagues Johannes Buchner, professor of biotechnology and Sevil Weinkauf, professor of electron microscopy, Reif determined that the small heat shock protein uses a specific non-polar beta - sheet structure pile in its center for interactions with the beta - amyloid, allowing it to access the aggregation process in two locations at once: For one it attaches to individual dissolved beta - amyloids, preventing them from forming fibrils.

A plaque is an accumulation of proteins that are primarily made up of Amyloid beta (A-beta), a small structure that splits off from the Amyloid Precursor Protein (APP).

Diamond and his colleagues have shown that a part of nerve cells» inner structure known as tau protein can misfold into a configuration called an amyloid.

The team found that the Amyloid beta proteins entered the cells of the retina within 24 hours of exposure and then began to break the cell's scaffold structure.

This is a drawing representing structure of properly functioning protein (left) which is optically invisible to high power laser light, and toxic amyloid (right) responsible for brain diseases that might potentially be cured using lasers in photo therapies.

These reagents, prepared against human light chain - related fibrils, recognize an epitope common to the beta - pleated structure of AL and other types of amyloid proteins and can effect rapid amyloidolysis when administered to mice injected with human AL amyloid extracts.

In recent years, scientists made the surprising discovery that seminal fluid harbors fragments of proteins that clump together, forming structures called amyloid fibrils.

Amyloid fibers, those clumps of plaque - like proteins that clog up the brains of Alzheimer's patients, have perplexed scientists with their robust structures.

In the October 19, 2006, issue of Nature (available online Oct. 11), the researchers describe the structures of insulin - degrading enzyme (IDE) in complex with four of the proteins it digests: insulin, amyloid - beta, amylin and glucagon.

Researchers from the University of Chicago and Argonne National Laboratory have deciphered the three - dimensional structure of insulin - degrading enzyme, a promising target for new drugs because it breaks down not only insulin but also the amyloid - beta protein, which has been linked to the cognitive decline of Alzheimer's disease.