So Smith sent crystals of the vitamin to University of Oxford chemist Dorothy Crowfoot Hodgkin, a pioneering crystallographer who had solved
the structure of penicillin.
Not exact matches
Some
of the molecular
structures, in
penicillin and vitamin B - 12 for example, were quite surprising.
Her lab later came up with
structures for
penicillin, which influenced the development
of antibiotics, and for vitamin B - 12, which her group determined with the aid
of one
of the first electronic computers.
To help on this front, in a new paper published in the journal
Structure, researchers from McGill University present in atomic detail how specific bacterial enzymes, known as kinases, confer resistance to macrolide antibiotics, a widely used class
of antibiotics and an alternative medication for patients with
penicillin allergies.
With just a bachelor's degree, she began working in the lab
of protein crystallography pioneer and Nobel Laureate Dorothy Hodgkin, who solved
structures for
penicillin, Vitamin B12 and insulin.
After scientists figured out in 1943 that
penicillin contains a sulfur atom, they had two main hypotheses
of its
structure.