The scientists propose that Src42A — a protein that belongs to the family of kinases that regulates
the structure of the actin filament — is one of the main contributors to this system.
Not exact matches
She wrote her dissertation on pollen sterility in petunias, but she also studied cell
structure, which led her back to animals and a postdoc at the Scripps Research Institute in San Diego, California, where she studied a protein on the ends
of actin filaments.
After attaching to the cell membrane
of its target, it releases a protein that enters the cell, where it communicates with
actin — a protein that helps maintain the cell's
structure.
Here, in fission yeast the
actin ring was found to be required to generate late - mitotic microtubular
structures located at the division plane, and these in turn maintained the medial position
of the
actin ring.
Notably, it also disrupts the activity
of a specific protein, CYFIP1, which regulates eIF4E as well as
actin dynamics and the
structure of dendrites — components
of a neuron where inputs from other neurons are located.
Not only did the group succeed in visualizing the real time events
of zygote polarization and asymmetric cell division, they were able to quantify the dynamic patterns
of the cytoskeleton (i.e. formation
of the ring
structure and longitudinal array
of MTs and F -
actin, respectively).
Activity
of the effector proteins result in effacement
of the brush border, induction
of massive membrane ruffles and formation
of novel reticular F -
actin structures in a highly dynamic manner.
At the time, Kabsch was working on his main project, solving the
structure of the muscle protein
actin.
After 14 months
of exploring the detector and coding all
of its features into a Fortran - based software tool, he was able to solve the
actin structure with the excellent data from the new detector, rendering the film - based approach obsolete.
Structure / Function Analysis
of the Interaction
of Phosphatidylinositol 4, 5 - Bisphosphate with
Actin - capping Protein.
Disassembly
of actin structures by nanosecond pulsed electric field is a downstream effect
of cell swelling.
In addition, breast cancer cells respond differently to S1P in terms
of the regulation
of actin cytoskeletal
structures.
S1P also induces formation
of cortical
actin structures in non-transformed cells, but not in breast cancer cells.
Pai and Kabsch were part
of a group that collaborated to solve the first
actin structure, a challenge because muscle proteins polymerize and don't form crystals.
A final note on the fate
of amino acids - once absorbed, amino acids can be used directly by cells for the synthesis
of new enzymes or new cell
structures, for the building
of structural proteins (such as
actin and myosin in the muscles), for the synthesis
of OTHER amino acids (via transamination), or used for energy.