The results were published in the journal Lab on a Chip (Lab on a Chip 17 (19), 3291 - 3299) in an article called: «Magnetic particles assisted capture and release of rare circulating tumor cells using wavy - herringbone
structured microfluidic devices.»
Not exact matches
As it can take weeks to grow human cells into intact differentiated and functional tissues within Organ Chips, such as those that mimic the lung and intestine, and researchers seek to understand how drugs, toxins or other perturbations alter tissue
structure and function, the team at the Wyss Institute for Biologically Inspired Engineering led by Donald Ingber has been searching for ways to non-invasively monitor the health and maturity of cells cultured within these
microfluidic devices over extended times.
Microfluidic devices are tiny chips that can sort out disease biomarkers, cells and other small
structures in samples like blood by using microscopic channels incorporated into the
devices.
«These highly elusive 3 - nanometer
structures are too small to be captured with other types of liquid biopsy
devices, such as
microfluidics, due to shear forces that can potentially destroy them,» he noted.
The
microfluidic device designed by his team captures cells based on their distinct internal
structure — a mechanical analysis instead of the blood chemistry analysis used in conventional medical diagnostic techniques.