The final outcome is a detailed 3D view of the molecular
structures at atomic resolution.
That work triggered a close race between the Cambridge University group and a rival team at MIT in deciphering tRNA's 3D
structure at atomic resolution with x-ray crystallography, with the two labs publishing results within 2 weeks of each other.
Not exact matches
«Understanding how the enzyme actually works requires the knowledge of its three dimensional molecular
structure at the
atomic level,» said Dr. Mueller, principal investigator for the study that used cryo - electron microscopy (cryo - EM) to reveal the enzyme
at near
atomic resolution.
While cryo - EM isn't new, advancements in technology have made it possible to solve the
structure at near
atomic resolution.
Using this method, the biological molecules» three - dimensional
structure can be determined
at a nearly
atomic resolution.
The first included pictures of individual nanoparticles»
atomic structures at 100,000 - times magnification — the highest
resolution images ever taken of nanoparticles in a liquid environment.
Now a team led by x-ray crystallographer Wayne Hendrickson
at Columbia University in New York City and molecular virologist Joseph Sodroski
at the Dana - Farber Cancer Institute in Boston has determined gp120's
atomic structure to a
resolution of 2.5 angstroms.
Taking this as his basis, he used x-ray diffraction experiments to elucidate its spatial
structure at the level of
atomic resolution.
LiWang's lab also collaborates with X-ray crystallographers like Carrie Partch
at the University of California, Santa Cruz, because X-ray crystallography is a powerful technique to capture static
structures of proteins and their complexes
at atomic and near -
atomic resolution.
Scientists are providing the clearest view yet of an intact bacterial microcompartment, revealing
at atomic - level
resolution the
structure and assembly of the organelle's protein shell.
«When combined with previous work, it is remarkable now to be able to assemble a true molecular movie of the photocycle of this blue light detector in bacteria
at atomic resolution, with the intermediate
structures appearing and fading in the correct sequence.
A European research team and a team from the United States (Massachussetts Institute of Technology in cooperation with Lund University) have simultaneously succeeded in elucidating the
structure of the most disease - relevant beta - amyloid peptide 1 - 42 fibrils
at atomic resolution.
I am an experimentalist, and I use ultrahigh -
resolution ion - and electron - microscopy techniques, including focused - ion - beam scanning - electron microscopy and transmission electron microscopy, to determine the composition and
structure of these materials
at scales ranging from millimeters down to the
atomic.
While there are very good bioinformatics tools for the analysis, validation and comparison of detailed
atomic structures,
at present there are very few tools available to work with low -
resolution data (i.e. volume or shape data).
X-ray crystallography allowed scientists to «see» the
structure of matter — whether it was molecular or otherwise —
at atomic resolution.
Several more researchers presented their work during the day, including protein synthesis
at atomic resolution, bio-imaging opportunities
at synchrotrons, multi-dimensional imaging during plant cell differentiation, how to use electron cryomicroscopy for in situ structural biology, and how
structured illumination microscopy can offer insights into the regulation of mammalian meiosis.
«Fitzpatrick and colleagues have paved the way for development of new drugs designed to prevent tangle formation by deciphering the molecular
structure of the «tau» protein filaments that make up the tangles
at atomic resolution.
«I was very excited to see the electron density map and how you can determine the
structure at near
atomic resolution,» Dong says.