Sentences with phrase «studied as a biomarker»
Not exact matches
While we are unaware of any prior studies relating As biomarker concentrations to rice intake among infants, associations have been observed in pregnant women in our cohort, 19 children in the National Health and Nutrition Examination Survey, 16,18 and multiple studies of adults.11 - 15
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For researchers using mouse models to study a variety of cancers, including lymphoma, melanoma, breast, and prostate cancers as well as autoimmune and infectious diseases, the panel facilitates a highly sensitive and high - throughput investigation of biomarkers associated with disease progression.
This new study of non-military, civilian trauma patients visiting the emergency department builds on recent research conducted by Dr. Samadani, supported through the Cohen Veterans Center, which found that the use of this novel eye - tracking technology could reveal edema, or swelling, in the brain as a potential biomarker for assessing brain function and monitoring recovery in people with head injuries.
Human sperm may hold the potential to serve as biomarkers of the future health of newborn infants, according to a new study by a Wayne State University School of Medicine research team.
«We hope that our work will provide the basis for a larger study of patient samples that may ultimately identify biomarkers that can be used as surrogate markers to determine the benefit of therapeutic interventions in diagnosed but asymptomatic HD patients to prevent or delay disease onset.»
The foundation's latest gift will fund the purchase of the Simoa technology and support Dr. de Leon's research to study its use as a potential biomarker for TBI.
While the study included a large number of vascular risk factors, no information was available on individual biomarkers, or migraine specifics such as the presence or absence of migraine aura.
The members of the initiative hope to improve early detection of cancer by making an impact in a variety of areas, including doing epidemiologic studies on risk factors, developing new and improved methods of diagnostic imaging, discovering and verifying new biomarkers as indicators of cancer, and developing new technologies to aid early detection.
The larger scale Cancer Genome Atlas study provided the information needed to alter proteins or RNA sequences that may act as «drivers» for prognostic biomarkers or therapeutic targets.
Another limitation of the study was that researchers did not analyze a blood biomarker called C - Reactive Protein (CRP) as a measure of inflammation to select patients to be enrolled into the study.
The next steps are to implement sequencing - based biomarker assays, such as reported in our study, in accredited pathology laboratories.
«Our results, and methods, could have implications for the analysis of endogenous and exogeneous compounds in the exhaled breath as biomarkers of systemic and lung diseases, as well as in development of new approaches to study human exposure to airborne contamination.»
The HOPE study looked at the effect of exercise on body weight, body fat, and inflammatory biomarkers in 121 women with joint pain from taking aromatase inhibitors (AI) as adjuvant therapy.
«Other studies have identified a connection between inflammation biomarkers and pregnancy complications such as pre-eclampsia and gestational diabetes,» Palomba said.
While the current study controlled for a large number of vascular risk factors, no information was available for vascular biomarkers, and migraine specifics, such as migraine aura.
The exact mechanisms must be probed in further animal studies, Reid says, but eventually he hopes researchers will be able to use a patient's bacterial makeup as a biomarker for cancer screening or to develop probiotics for improving prognosis and treatment outcomes.
And, critically, the study showed that levels of two biomarkers, known as L - threonine (an amino acid) and vitamin D binding protein, may accurately predict which patients live and which die.
In previous studies, the same group along with others had demonstrated that microRNAs (miRNAs) produced by eukaryotic cells and viruses are present in human blood in highly stable, cell - free forms and these so called circulating miRNAs can serve as non-invasive biomarkers for the early diagnosis of various diseases, including viral diseases.
This study looked at the use of head circumference and head tilting reflex as two biomarkers that can be used during well - baby visits by primary care providers.
«In this study, we wanted to explore the association between children's personal social networks, as well as perceived social network size and density with biomarkers like cortisol and alpha - amylase that can indicate levels of stress in youth.
This study looked at the use of head circumference and head tilting reflex as two biomarkers that can be used during their well - baby visits by their primary care providers.
In addition to illustrating the experimental role of a sucralose - maltodextrin based artificial sweetener in promoting intestinal dysbiosis [a microbial imbalance] and myeloperoxidase activity, the studies indicate that it might be possible to measure Proteobacteria and myeloperoxidase as simultaneous fecal biomarkers in patients to monitor their gut (disease / health) adjustment to their diets.
«This is how we can start thinking about precision medicine in action,» said the study's senior author, Alice S. Chen - Plotkin, MD, an assistant professor of neurology at Penn. «We found that a relatively common genetic variation can both serve as a biomarker for and influence the disease course of Parkinson's patients.
Dr Margaret O'Hara, from the Molecular Physics Group and primary investigator on the project, said: «Previous studies have found potential biomarkers for liver disease, such as isoprene and acetone, but they are not specific enough because they are possible biomarkers for other diseases or can arise from numerous normal metabolic processes.
Several large - scale, federally funded epidemiological studies are under way to pinpoint possible environmental triggers, as well as early biomarkers of autism.
In a study published in the May / June issue of mBio, an online open - access journal from the American Society of Microbiology, the researchers found that the microorganisms found in must — freshly - pressed grape juice, before fermentation — can be used as biomarkers to predict which metabolites will be found in the finished wine.
«Our present study shows examination of the gene expression profiles at the very early age of initial clinical detection reveals both strong evidence of early biological processes in ASD and abnormal signals with the potential to serve as an early, practical biomarker of risk for the disorder in general pediatric settings.»
In one VA - funded study, he is using a type of electroencephalography (EEG)-- in which veterans wear an electrode - studded cap on their head — to trace brain patterns that may eventually serve as biomarkers.
Two years later a company called Onconome that helped fund the study and related research sued Hopkins, Getzenberg, and his former institution, the University of Pittsburgh, alleging that the biomarker test was «essentially as reliable as flipping a coin.»
These macrophage - derived mediators may have potential as biomarkers to reflect the urinary stone risk, according to a new study from Japan, which was recently presented at the recent 2nd Meeting of the EAU Section of Urolithiasis and received Clinical Research Award.
Bettcher said the new findings could possibly serve as the focus of more in - depth studies aimed at developing a blood test to detect inflammation biomarkers years before symptoms of Alzheimer's appear.
Evaluation of 66 patients with JDM, recruited from the UK JDM Cohort and Biomarker Study and actively treated with anti-TNF agents, showed significant improvements in muscle and skin involvement, as well as in overall disease activity.
Their new study points to a biomarker in the cellular machinery that could not only serve as an early warning of colon cancer, but potentially be harnessed to counteract advanced forms of the disease, the second - largest cause of cancer death in the U.S.
In future studies, it will be important to measure the biomarker at several time points to determine whether levels of the biomarker increase as the disease progresses, Apte said.
Policymaking committees should consider giving less weight to food industry - funded studies, and include mechanistic and animal studies as well as studies appraising the effect of added sugars on multiple CHD biomarkers and disease development,» the article concludes.
«Future research will focus on optimizing the candidate therapies discovered by our team in this study as well as developing biomarkers that can be used to test the efficacy of other potentially promising drugs,» says Dr. Rothstein
As a consequence, data may be tainted by site -, study -, population -, or sample - specific anomalies and, therefore, not be sufficiently robust for biomarker discovery.
«Lastly, the technique we have pioneered will likely be a valuable tool for scientists and clinicians studying the biology of complex nanoparticle populations,» Dr. Zhang said, «and may aid in the development of diagnostic tests using them as biomarkers.»
This study is good example of a precision medicine themed approach to showing how a mechanistic understanding of the differential gene expression can yield biomarkers that can be used for early detection of disease, as well as potential therapeutic targets.
Current applications include studies related to carbon sequestration, as well as the development of biomarkers for breast and brain cancer, neurological diseases, and diabetes and kidney diseases, among others.
A recent study reported that two oxysterol species, 15HC and 15KC, were increased more than three-fold in the blood of multiple sclerosis patients, suggesting a potential use for these oxysterols as diagnostic biomarkers.
Recent studies showed that optic nerve damage in glaucoma triggers the production of autoantibodies, which could be used as biomarkers to glaucoma early detection.
Quyyumi's team has studied circulating progenitor cells extensively, both as a biomarker predicting regenerative capacity and outcomes, and as a potential therapeutic agent.
Why it matters: Because the secretome is important for tissue function and equilibrium as well as cell communication, proliferation and organization, studying these proteins may lead to new treatments and biomarker discovery.
Results of this study has shown that there is a significant inter-population variability, as far as pharmacogenomic biomarker allele frequency is concerned, which has a direct impact on the rationalization of drug use at a population level.
Researchers at Emory University School of Medicine, led by principal investigator Michael Frankel, MD, Emory professor of neurology and director of Grady Memorial Hospitalâ $ ™ s Marcus Stroke & Neuroscience Center, are studying biomarkers as part of two ancillary studies of blood samples using two grants from the National Institutes of Health.
Data on patients receiving active drug in the trial were consistent with a dose - dependent improvement in some parameters of lung function examined in the study, including methacholine challenge test and peak expiratory flow rates, as well as in a biomarker associated with asthma severity and inflammation.
Through regional networks in the U.S. like the Pediatric Neuromuscular Clinical Research (PNCR) Network and Project Cure, and international organizations such as the International Coordinating Committee (ICC) and TREAT - NMD, the SMA community has collaborated effectively on recruiting patients, establishing standards of care, standardizing outcome measures, and supporting multi-site clinical efforts, such as the Biomarkers for SMA (BforSMA) and the PNCR Network Natural History studies.
«We are proposing that the disease be defined in living people by evidence of brain pathology using biomarker studies, either brain imaging or body fluid examination, and that clinical symptoms should be regarded for what they are — a product or result of the disease, as opposed to the definition of the disease,» said lead author Dr. Clifford Jack, Jr. of the Mayo Clinic.
Moreover, this study will determine whether changes in retinal microvasculature can be used as a biomarker or clinical indicator for monitoring progression of glaucoma in clinical practice.