Sentences with phrase «studied cell viability»

Not exact matches

Last week, scientists at Harvard University and Columbia University announced that they had proved the viability of a new way to study a disease — amyotrophic lateral sclerosis — by reprogramming cells from a patient to become pluripotent stem cells, which can then become any type of cell or tissue.

The study found that combining the two drugs had an increased effect of killing of cancer cells, while individually, the drugs have considerably less impact on cell viability.

The other study published in the American Chemical Society's Applied Materials & Interfaces reported a method for fabricating titanium implants with special surface topographies which double the chance of cell viability in early stages.

In the new study, Popp exposed breast cancer cells to doxorubicin alone and measured their viability following treatment.

Scientists say they have proved the viability of a new way to study diseases using a patient's own cells.

Cell viability and apoptosis studies.

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Some of the long term aims of the studies are (i) to contribute to the understanding of the mechanisms that control cortical development and evolution, (ii) to use the knowledge to grow neural stem cell populations of high purity and viability for therapeutic approaches and (iii) to study how neural stem cells can be activated in vivo.

RPE cells derived from HESC show long - term viability in vivo, since in a previous study we have shown that HESC - derived RPE can survive in the RCS subretinal space for up to 10 weeks [9], whilst a recent study has indicated survival of cells for up to 30 weeks [59].

And a June 2014 study found that radiation from cell phones can lower men's sperm mobility by 8 % and sperm viability by 9 %.