Sentences with phrase «studied epigenetic mechanisms»

One of the most studied epigenetic mechanisms is a process called DNA methylation, which was the focus of the current study.

In order to identify the cancer stem cells from other cells in the tumor, the research team studied epigenetic mechanisms that distinguish between the least - sorted cells, with endless division properties and a potential to create growth, and the more sorted cells which lack this ability.

The research centre currently consists of seven groups studying epigenetic mechanisms regulating cellular differentiation programs.

Not exact matches

Specifically, the study reveals a mechanism that helps explain how dividing cells pass patterns of epigenetic information called methyl tags to their daughter cells, a crucial part of regulating gene expression across cell generations.

«Our study connects the dots between Werner syndrome and heterochromatin disorganization, outlining a molecular mechanism by which a genetic mutation leads to a general disruption of cellular processes by disrupting epigenetic regulation,» says Izpisua Belmonte.

Such epigenetic mechanisms are high on the list of suspects when it comes to explaining how environmental factors that affect parents can later influence their children, such as in the Dutch second world war study, but just how these epigenetic changes might be passed on to future generations is a mystery.

And because epigenetic changes typically occur early in life, it may one day be possible to identify young people at risk for suicide by studying their methylation patterns and then to treat them with drugs that regulate this mechanism, Szyf notes.

Interestingly, this study shows that altered dopamine levels can modify gene activity through epigenetic mechanisms despite the absence of genetic mutations of the DNA.»

The transgenerational epigenetic mechanism of microRNA differed from a study that showed how treating the father's symptoms of an inherited disease can epigenetically treat the son.

Since then, various reports suggested epigenetic inheritance in different organisms but the molecular mechanisms were unknown,» says Nicola Iovino, corresponding author in the new study.

While further research is needed to understand the effectiveness of H1.0 protein in preventing the spread of cancer growth, this research advances significantly the study of the mechanisms of cancer stem cells and the relatively new epigenetic approach to cancer research.

In particular, he wanted to study the genomes of marbled crayfish to uncover basic mechanisms underlying epigenetics, the binding of molecules to DNA that can drive tumor growth and help cancer spread.

By studying this new mechanism we hope to expand our knowledge of epigenetics in general as well as adding to our understanding of fertility.»

«Future studies on maternal smoking and other environmental, genetic, and epigenetic factors, as well as animal models, should allow identification of the biological mechanisms responsible for these associations.

To understand the underlying mechanism for how this may occur, she is also conducting epigenetic studies to determine where in the genome this acclimatization effect takes place.

They suggest that future studies should investigate specific mechanisms that cause this so - called epigenetic drift in identical twins.

«Grape - derived compounds may promote resilience against depression, researchers find: New study used DNA epigenetic mapping to analyze novel inflammatory mechanisms influencing brain circuitry associated with depression.»

This study represents a step forward in understanding the underlying mechanisms of T - cell function and epigenetic regulation of the HDAC11 enzyme.

His group is are studying the mechanism of stable inherited epigenetic transcriptional repression by Polycomb - group (Pc - G) protein complexes, and the effects of deregulation of Pc - G genes on Homeobox gene expression, development, Cell cycle control and cancer formation.

A new study by Mark Bedford, Ph.D., professor of Molecular Carcinogenesis, and colleagues published in Molecular Cell sheds light on the mechanism by which TDRD3 — a protein that «reads» epigenetic marks on chromosomal proteins — turns on certain genes.

Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.

The first of its kind, the study provided specific markers to distinguish different disease states in asthma and paved the way for investigating the role of epigenetic mechanisms in other immune - mediated disorders and infectious diseases.

Embryonic stem cells, Adult stem cells, Reprogramming to pluripotency and lineage conversion, Directed differentiation, Germ cells, Genetic and epigenetic mechanisms, Stem cells in development, Stem cell niche, Cancer stem cells, Disease modeling and drug screening, Stem cell therapy, Clinical studies in regenerative medicine, Tissue engineering and biomaterials, Imaging and diagnostics, Stem cell products, manufacturing, and quality control, Ethical, legal, and social issues Read Journal

«Study of the pro-apoptotic effect of molecules interfering with epigenetic mechanisms on human lung cancer cells».

Changes in an epigenetic mechanism that turns expression of genes on and off may be as important as genetic alterations in causing pediatric acute lymphoblastic leukemia (ALL), according to a study led by scientists at St. Jude Children's Research Hospital and published in the June 10 online edition of the Journal of Clinical Investigation.

I study genetic and epigenetic changes induced by smoking and other environmental factors to identify the mechanisms that play a role in carcinogenesis.

Several candidate mechanisms of CRCI have been proposed, including inflammation and cytokine dysregulation, chemotherapy - induced epigenetic changes, blood — brain barrier disruption, hormone deficiencies, oxidative DNA damage and shortened telomere length, and genetic susceptibility.21 — 26 However, the heterogeneity and design limitations within the emerging body of evidence have led to recommendations for harmonising study methodologies and moving towards multisite, longitudinal research.3 27 Such approaches would support the demonstration of robust relationships between measurable biological processes and cognitive outcomes.

Significant insight into this critical issue comes primarily from animal studies and from recent translation research in humans investigating epigenetic mechanisms.20, 21

Based on a modified version of Gottlieb's scheme of psychobiological development, this study conceptualizes epigenetic mechanisms as molecular underpinnings mediating interactions between neural and

Based on a modified version of Gottlieb's scheme of psychobiological development, this study conceptualizes epigenetic mechanisms as molecular underpinnings mediating interactions between neural and... genetic activity levels.