Sentences with phrase «studied epigenetic signals»
DNA methylation, or the addition of methyl tags to DNA, is one of the most well - studied epigenetic signals; errors in this process are commonly found in cancer.
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Scientists from the cluster of excellence BIOSS Centre for Biological Signalling Studies at the University of Freiburg and the Freiburg University Medical Center have shown that inhibiting the epigenetic regulator KDM4 might offer a potential novel treatment option for breast cancer patients.
All animals use the same enzyme to create the same methylation mark as a signal for gene repression, and her colleagues who study epigenetics in mice and humans are excited about the new findings, Strome said.
This is the first study to demonstrate an epigenetic model of nitric oxide signaling that has the potential to «change our fundamental understanding of both nitric oxide biology and epigenetic regulation,» Thomas said.
Gilean McVean, who studies statistical genetics at the University of Oxford University in the United Kingdom, says much stronger data are needed to make the case that nutritional signals are transmitted through epigenetics.
Various previous studies had shown that epigenetic remodeling of DNA by methylation or demethylation led to changes located in synapses, where one neuron communicates with another by chemical or electrical signals sent across a small gap.
Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported by Bpifrance about the treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in cancers.
In 2007, he was awarded a prestigious National Career Development Fellowship to undertake translational studies in the epigenetic regulation of the immune cell signaling molecules in human asthma under the mentorship of K. Mark Ansel, Ph.D., at UC San Francisco, where he was appointed adjunct assistant professor in the Department of Medicine in 2009.