Sentences with phrase «studied thalidomide»
Toxicologist Craig Harris of the University of Michigan, Ann Arbor, who has studied thalidomide's effects on gene expression, says that the new data are consistent with some theories of the drug's action, however.
http://www.sciencemag.org/ Not exact matches
Although thalidomide has been the subject of hundreds of studies, we still do not know exactly how it causes its effects.
When asked by Nature for relevant studies, the plaintiffs» lawyers at Hagens Berman Sobol Shapiro in Seattle, Washington, pointed to work showing one - sided limb defects in chick embryos exposed to thalidomide and thalidomide analogues (C. Therapontos et al..
«There are no representative, controlled studies documenting the true spectrum of thalidomide injuries,» they write in the lawsuit.
The pharmacologist felt the animal studies submitted were not a good indication of possible toxicity in humans, since animals absorb thalidomide poorly.
At the FDA, Kelsey determined that thalidomide studies were incomplete and did not support the maker's claims.
A new study published in the March 12 issue of Science has identified one primary target of thalidomide's teratogenicity (potential to cause fetal malformations)-- a protein called cereblon.
A pilot study of thalidomide, published in 2001, found the drug improved blood counts in some patients and enabled others to become transfusion - independent.
New treatment regimens using thalidomide or lenalidomide are also being studied.