Sentences with phrase «studies cell cycles»

Moreover, the Galli group studies cell cycles that lead to polyploidization, such as endoreplication and endomitosis, and how these cycles are regulated in normal physiology and in disease.

Although the regulation of this gene has a strong «cell cycle control» component, I was more interested in studying cell cycle regulation «proper.»

«We are currently developing tools in the lab to study the cell cycle and cellular morphology of Sulfolobus at the single - cell level under the microscope.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

He spent his last year as a Lisbon student studying cell - cycle regulation in yeast at the University of Manchester in the United Kingdom, with an Erasmus scholarship from the European Commission.

Chu says the study emphasizes that healthy cells need more than functional mitochondria — they need to support a kind of mitochondrial life cycle that involves continuous genesis, repair and recycling.

I had spent 4 years studying the interactions between two proteins involved in the cell cycle and DNA replication and repair.

The study found that carfilzomib and irinotecan have a potential synergistic effect in SCLC and other Irinotecan - sensitive cancers by allowing normal DNA damage repair and enabling normal cell - cycle death.

She still does not know why he considered her at the time — «Maybe it was just my enthusiasm,» she wonders — but he nonetheless became her mentor as she studied the transcriptional activation of the cell - cycle regulated HO gene in the yeast Saccharomyces cerevisiae.

He hopes to pursue projects such as developing therapeutics with chemists, working with biophysicists to study protein conformational changes relevant to viral entry into the cell, and investigating cellular trafficking pathways relevant to the viral life cycle in collaboration with cell biologists.

Igoshin said that when the researchers set out to find how sporulation decisions were timed to the cell cycle, several studies including prior work by team members, provided a significant clue: Under starvation conditions, the activity of the master regulator gene had been shown to spike once per cell cycle.

In the new study, Narula, Igoshin and collaborators set out to explain how B. subtilis times its sporulation decision with its cell - division cycle, a programmed series of events that cells normally follow to reproduce.

This study, published recently in PLOS Genetics, shows that in the particular case of meiotic cells such as spermatocytes, the signalling route of the ATM protein also participates in the control system of the cell cycle progression in response to DNA damage, something which until now was unknown.

Researchers take advantage of this feature to obtain populations of synchronized bacteria that can be used to study specific cell cycle processes.

Lee's study results, which appear in the July 16, 2015 issue of Nature Communications, revealed new understanding about how 14 -3-3 sigma — a cell cycle «controller» - regulates cancer metabolic programming, thus protecting healthy cells from turning into tumor - producing factories.

Lee believes that the study findings provide additional insight about the «crosstalk» between cancer metabolism and cell cycle.

The study, which can be read in Nature Communications, shows the transcription factor family MYB3R prevents progression to the division stage (M phase) of the cell cycle in Arabidopsis, a small flowering plant that is a member of the mustard family.

It also undergoes cell division by first creating copies of chromosomes like most human cells and has a very fast replication cycle, all of which facilitated the study.

The budding yeast, Saccharomyces cerevisiae, is a prime organism for studying fundamental cellular processes, with the functions of many proteins important in the cell cycle and signaling networks found in human biology having first been discovered in yeast.

The studies on autophagy by Yoshinori Ohsumi, which earned him the Nobel Prize in Medicine in 2016, and the discovery of cell cycle regulatory genes for which Leland Hartwell, Timothy Hunt and Paul Nurse received the same award in 2001, including the research of Elizabeth Blackburn, Carol Greider and Jack Szostak on telomeres, telomerase and its protective effect on the chromosomes, were all made possible thanks to yeast.

The study has benefitted from the participation of CNIO researchers Marcos Malumbres and Ignacio Pérez de Castro, who are experts on protein AURKA and its role in the cell cycle.

The scientists involved with this study were able to demonstrate that translocations can occur within hours of DNA breaks and that their formation is independent of when the breaks happen during the cell division cycle.

«Our study found that by introducing an inhibitor of the STAT3 protein in repeated cycles, we could alternately replenish the pool of satellite cells and promote their differentiation into muscle fibers,» said Alessandra Sacco, Ph.D., assistant professor in the Development, Aging, and Regeneration Program at Sanford - Burnham.

Some of the common genetic alterations identified in the study were gains and losses in chromosome 8, as well as cell proliferation and cell - cycle progression — key mechanisms of cancer caused by genetic alterations — linked to the genes AURKA, AURKB and FOXM1.

Other studies have shown that the virus is capable of moving into brain cells, modifying the regulation of the cell cycle, and inducing their death.

This study, which will be published Oct. 24 in eLife, and two other new Northwestern studies in Oncotarget and Cell Cycle by the Peter group, describe the discovery of the assassin molecules present in multiple human genes and their powerful effect on cancer in mice.

His team discovered these special sequences are distributed throughout the human genome, embedded in multiple genes as shown in the study in Cell Cycle.

«The CDK4 and 6 proteins are critical drivers of the cell - division cycle and are required for the formation and growth of various types of solid tumors,» says Dana - Farber's Shom Goel, MD, PhD, co-first author of the study with Molly DeCristo of the Hematology Division at BWH.

«While it was known that palbociclib stalls proliferation by inhibiting CDK4 / 6, inducing proteasomal activity may be an additional mechanism that ensures the completeness of the cell cycle arrest,» says Dr. Mikael Björklund, one of the lead authors of the study.

LA JOLLA, CA — A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells.

In search of a mechanism behind the finding that HIV / gp120 reduced proliferation of aNPCs, the scientists studied the effect of the protein on the cell cycle.

Previous studies of beta cell proliferation generally have focused on mechanisms that kick off the cell cycle that leads to successful cell division.

In this new study, licensing refers to origin licensing, the process of helicase loading onto DNA for genome duplication purposes during the G1 phase of the cell cycle.

The study, commissioned by CHEOPS - a perovskite research project co-funded by the European research and innovation programme Horizon 2020, is being conducted by SmartGreenScans, a CHEOPS member, specialising in Life - Cycle Assessments (LCA) of photovoltaic technologies, to assess the life - cycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by OxforCycle Assessments (LCA) of photovoltaic technologies, to assess the life - cycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by Oxforcycle environmental impact of the perovskite - on - silicon tandem cells being commercialised by Oxford PV.

His group is are studying the mechanism of stable inherited epigenetic transcriptional repression by Polycomb - group (Pc - G) protein complexes, and the effects of deregulation of Pc - G genes on Homeobox gene expression, development, Cell cycle control and cancer formation.

The Institute is currently running on a Site License by Flowjo, a flow cytometry data analysis software package which offers a range of analysis platforms that includes compensation, cell cycle, proliferation studies and kinetics.

Oxford, 04 April 2018 — Oxford PV — The Perovskite Company, the leader in the field of perovskite solar cells, today announced that its perovskite - on - silicon tandem solar cells, currently being used to conduct a life - cycle environmental impact study, have shown positive first results.

In our study, we found that exposing metastatic breast cancer cell lines to hypoxia and reoxygenation cycles induces a unique subpopulation that is highly metastatic and exhibits stem - like and EMT phenotypes.

Cell cycle studies also showed that inhibition of mTOR function by using rapamycin or inhibition of mTOR expression by using mTOR - specific siRNA induced cell cycle arrest as shown by a dose - dependent decrease of cell cycle S phase (data not shoCell cycle studies also showed that inhibition of mTOR function by using rapamycin or inhibition of mTOR expression by using mTOR - specific siRNA induced cell cycle arrest as shown by a dose - dependent decrease of cell cycle S phase (data not shocell cycle arrest as shown by a dose - dependent decrease of cell cycle S phase (data not shocell cycle S phase (data not shown).

The Galli group studies the regulation of the cell cycle during development and tissue formation.

In our study, we found that the emergence of a small non-adherent subpopulation (approximately 1 %) survived after the first hypoxia / reoxygenation cycle and speculate that cyclic exposures of hypoxia and reoxygenation may select for the stem - like subpopulation with the ability to overcome replication arrest whereas the majority of non-adherent cells can not.

Maria Anna Ciemerych began her research with studies focusing at the cell cycle regulation of mouse oocytes and preimplantation embryos (Ph.D. at the University of Warsaw), then investigated the role of the cell cycle regulators - D - type cyclins, in mouse development (Dana Farber Cancer Institute, Harvard Medical School).

To study the effect of hypoxia / reoxygenation cycles on breast cancer, we exposed two metastatic human breast cancer cell lines (MDA - MB 231 and BCM2) to cycles of chronic hypoxia and nutrient deprivation.

His group also studies two genes implicated in familial breast cancer, BRCA1 and BRCA2, and recently demonstrated that their action is linked to the cell's division cycle, and that BRCA1 regulates gene activity.

Dr. Verma's group is also studying two genes implicated in familial breast cancer, BRCA1 and BRCA2, and recently demonstrated that their action is linked to the cell's division cycle and that BRCA1 regulates gene activity.

Our favorite experimental system is the Xenopus egg extract system for studies on cell cycle progression and regulation, microtubule dynamics, spindle assembly and chromosome behaviour (Karsenti and Vernos, 2001).

This is in accordance with previous reports that decitabine and 5 - azacytidine produce a marked synergistic effect in combination with suberoylanilide hydroxamic acid and romidepsin in T - lymphoma cell lines by modulating cell cycle arrest and apoptosis.26, 27 As a mechanism of action, KMT2D mutations of B - lymphoma cells promote malignant outgrowth by perturbing methylation of H3K4 that affect the JAK - STAT, Toll - like receptor, or B - cell receptor pathway.28, 29 Here our study indicated that dual treatment with chidamide and decitabine enhanced the interaction of KMT2D with the transcription factor PU.1, thereby inactivating the H3K4me - associated signaling pathway MAPK, which is constitutively activated in T - cell lymphoma.13, 30,31 The transcription factor PU.1 is involved in the development of all hematopoietic lineages32 and regulates lymphoid cell growth and transformation.33 Aberrant PU.1 expression promotes acute myeloid leukemia and is related to the pathogenesis of multiple myeloma via the MAPK pathway.34, 35 On the other hand, PU.1 is also shown to interact with chromatin remodeler and DNA methyltransferease to control hematopoiesis and suppress leukemia.36 Our data thus suggested that the combined action of chidamide and decitabine may interfere with the differentiation and / or viability of PTCL - NOS through a PU.1 - dependent gene expression program.

Topics spanned the entire field of cancer research, from molecular studies of cell cycle proteins to the role of vegetable consumption in cancer prevention.

REVEALED: Scientists have found a way to stop ageing A huge study, published in Ageing Cell, has found cycling keeps you young past the age of 55.

«This is the first study to identify a cell cycle transcriptional co-regulator that controls these processes.