Sentences with phrase «studies early mouse»

His laboratory studies early mouse development as a model system to understand molecular mechanisms leading to establishment of pluripotency in vivo.

Not exact matches

While we can't use sterile mice to make any definitive conclusions about humans, the twins study, published in the journal Science last year, provided clear evidence that the microbiome is involved in weight gain — something earlier research had only suggested.

Mothers who overeat during the period when they are breastfeeding may have children who are at increased risk of becoming obese and going through early puberty, a new study of mice suggests.

A study by researchers at the University of Chicago Medicine shows that when mice that are genetically susceptible to developing inflammatory bowel disease (IBD) were given antibiotics during late pregnancy and the early nursing period, their offspring were more likely to develop an inflammatory condition of the colon that resembles human IBD.

In a study published earlier this year, his team, along with scientists at Arcturus Therapeutics, treated hemophilia in mice using mRNA that encodes a clotting protein.

In the early»90s, Bartke wrote a grant application proposing to study the giant, growth - hormone - flooded mouse as an example of accelerated aging.

In this study, researchers analyzed ovarian tissue from populations of reproductively «young» (equivalent to women in their early twenties) and «old» mice (equivalent to women ages 38 - 45).

An earlier study had identified the connection between the thalamus — a brain region that relays incoming signals from the muscles and senses — and the dmPFC, along with the role this neural circuit can play in modifying a mouse's desire for confrontation.

So from our study using mice, the correct time to eat more would be earlier in the day.»

«These are the same symptoms — alongside others — that we also found among mice in our earlier studies.»

The study also found that a lack of exposure in early life could not be compensated for by introducing the GF mice to a broader range of microbes in adulthood.

Different types of studies use different stand - ins: Flies for genetics; zebrafish for early development; rats and mice and monkeys for cancer, neuroscience and more.

Based on our studies with mice, we assumed that the symptoms would emerge much earlier — perhaps after ten years,» says Dierks.

Now, in a provocative study that raises unsettling questions about the widespread use of vitamin supplements, Swedish researchers have showed that relatively low doses of antioxidants spur the growth of early lung tumors in cancer - prone mice, perhaps by hindering a well - known tumor suppressor gene.

Early but not advanced forms of atherosclerotic plaques in the vessel wall disappear when the levels of «bad» cholesterol are lowered, according to a study in mice from Karolinska Institutet, Sweden.

In earlier studies, Wang and his colleagues had revealed that a gene in mice called Pad4 (peptidylarginine deiminase 4) produces an enzyme that plays an important role in protecting the body from infection.

«While this study took place in mice, the work sets the scene to do early clinical trials in humans.

In a study published earlier this year, Jiang and other collaborators at Duke described a mouse model of autism in which they deleted a prominent autism gene called SHANK3, which is mutated in 1 percent of people with the disorder.

«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.

In the new study, the team genetically inactivated HIV - 1 in transgenic mice, reducing the RNA expression of viral genes by roughly 60 to 95 percent, confirming their earlier findings.

Earlier mouse studies by Li and his collaborators had indicated that the expression of several imprinted genes changes as hematopoietic stem cells embark on their journey from quiescent reserve cells to multi-lineage progenitor cells, which form the many highly specialized cell types that circulate within the blood stream.

Mouse studies have shown that stress, particularly early in life, can change microbial communities, and not in a good way.

To better understand what metabolic changes occur in place of fatty acid - burning, Kelly's team studied well established mouse models of the early and late stages of heart failure.

Yes, using mice in early drug studies can spare human test subjects from harm, which most people would argue justifies the frequently misleading findings.

«What we found early on was not all mice will mate with each other,» says clinical psychologist Melissa Farmer, who led the study while earning her Ph.D. at McGill University in Montreal, Canada.

Earlier studies had demonstrated that the chemical arvanil — with a chemical make - up similar to that of the spicy molecule capsaicin — was effective against brain tumours in mice; it reduces tumour growth in the animals.

A study in mice, published in Science in 2013, shows just how profound early differences can be.

As part of the study, co-authors Thad Stappenbeck, MD, PhD, professor of pathology and immunology, and Paul Allen, PhD, the Robert L. Kroc Professor of Pathology and Immunology, worked with mice they genetically altered to develop a condition similar to very early onset IBD.

IN THE BEGINNING Early embryos (a four - cell embryo shown) from mice and humans look the same on the outside, but gene activity studies show some big differences under the hood.

Mothers who overeat during the period when they are breastfeeding may have children who are at increased risk of becoming obese and going through early puberty, a new study of mice suggests.

In an earlier study, Spector's team knocked out the Malat1 gene in mice and curiously, these mice had no apparent abnormalities, a fact that would seem improbable if Malat1 did in fact have an important function.

The recent study follows a similar paper published earlier this month by developmental neurobiologist Jian Zuo, of St. Jude Children's Research Hospital in Memphis, Tennessee, who damaged sensory cells in live mice.

While earlier studies showed that mice lose their fear of bobcat urine for a few weeks after infection, Ingram showed that the three most common strains of Toxoplasma gondii make mice less fearful of cats for at least four months.

As in earlier studies, the investigators, led by Ren Hen of Columbia University, first created a line of so - called knockout mice that lacked the gene encoding the receptor protein.

«Earlier studies have shown that vitamin E can help regulate the aging body's immune system, but our present research is the first study to demonstrate that dietary vitamin E regulates neutrophil entry into the lungs in mice, and so dramatically reduces inflammation, and helps fight off infection by this common type of bacteria,» said first author Elsa N. Bou Ghanem, Ph.D., postdoctoral scholar in the department of molecular biology and microbiology at Tufts University School of Medicine (TUSM).

Radiation oncologist Anna Saran at the Italian National Agency for New Technologies, Energy and the Environment in Rome and colleagues studied mice with a mutation in a gene called Patched that makes them susceptible to brain tumors early in life.

Because tumor growth is a concern when cells are reprogrammed to an earlier stage of development, the researchers followed the mice in the Nature Cell Biology study for nearly a year to look for signs of tumor formation and reported finding none.

Finally, the study data suggest that RbAp48 protein mediates its effects, at least in part, through the PKA - CREB1 - CBP pathway, which the team had found in earlier studies to be important for age - related memory loss in the mouse.

«The research provides the first evidence that, as early as 15,000 years ago, humans were living in one place long enough to impact local animal communities — resulting in the dominant presence of house mice,» said Fiona Marshall, study co-author and a professor of anthropology at Washington University in St. Louis.

The study confirms that house mice were already a fixture in the domiciles of eastern Mediterranean hunter - gatherer villages more than 3,000 years before the earliest known evidence for sedentary agriculture.

In a study of mice with symptoms that mimic early Alzheimer's disease, the researchers found that while the mice had trouble recalling memories, those memories still existed and could be optogenetically retrieved.

Earlier studies had suggested that animals — including fruit flies, dogs and mice — live longer when they ate about 25 percent fewer calories than normal.

She is also developing a mouse model to study this very lethal brain cancer that occurs in early childhood.

Prior studies showed that this enzyme is produced early in the fracture healing process, and that deletion of the NOS2 gene delays healing in mice.

Schenk also revealed some very early information specific to PRX002, the humanized version of the most promising antibody tested in the mouse studies, which was then slated to enter into early - stage human trials.

A court in 1987 concluded that the LD50 studies in animals were «grossly inadequate» according to the standards in the early 1950's: the Army found that all mice died at 100 mg / kg and no mice died at 12 mg / kg, but the Army performed no further animal experiments.

In the study, which was conducted in collaboration with researchers at UC San Francisco and published today in the Journal of Neuroscience, scientists transplanted inhibitory neuron progenitors — early - stage brain cells that have the capacity to develop into mature inhibitory neurons — into two mouse models of Alzheimer's disease, apoE4 or apoE4 with accumulation of amyloid beta, another major contributor to Alzheimer's.

Earlier studies in overfed mice in gestation and lactation periods demonstrated IGT in male and female offspring of obese mice.

The findings are reported in two independent papers: the zebrafish study was published in the July 26 issue of Current Biology, the mouse study will be available in the early online edition of the Proceedings of the National Academy of Science this week.

«We are encouraged in this regard by the strong similarities we found between klotho's effects in humans and mice in our earlier study.