Sentences with phrase «studies in human patients»

Similar studies in human patients with pancreatitis have failed to document a benefit of FFP use.

It has also been shown that a fat - restricted diet does not ameliorate signs of EPI.40 In fact, the feeding of a high - fat and high - protein diet in combination with porcine - lipase maximized fat absorption in one experimental study in dogs with EPI.41 Studies in human patients also reveal that certain fiber sources (e.g., wheat bran, pectin) impair pancreatic enzyme activity, therefore, high - fiber diets should be avoided.42 Most dogs with exocrine pancreatic insufficiency do well when fed regular commercial maintenance diets.

Not exact matches

In a later study of the well - being of coronary patients, Holden (1981) reported that ownership of a pet among ninety - three patients was the strongest predictor of survival, stronger even than human relationships.

Although more and more human studies are being conducted to validate claims found in animals, many studies are with patients with a certain illness or condition (ex.

In order to protect infant safety and ensure the patient and human rights of mothers and babies, we have built a non-profit organization committed to: (1) the study of exclusive breastfeeding complications that can result in brain injury and, in the most severe instances, death; and (2) raising public awareness to signs of infant hunger and the consequences that can result based on peer - reviewed researcIn order to protect infant safety and ensure the patient and human rights of mothers and babies, we have built a non-profit organization committed to: (1) the study of exclusive breastfeeding complications that can result in brain injury and, in the most severe instances, death; and (2) raising public awareness to signs of infant hunger and the consequences that can result based on peer - reviewed researcin brain injury and, in the most severe instances, death; and (2) raising public awareness to signs of infant hunger and the consequences that can result based on peer - reviewed researcin the most severe instances, death; and (2) raising public awareness to signs of infant hunger and the consequences that can result based on peer - reviewed research.

The UI study, which was published March 28 online in the journal Molecular Psychiatry, adds to the accumulating evidence, including recent human studies from Harvard University, that suggests cerebellar stimulation might help improve cognitive problems in patients with schizophrenia.

When the researchers gave concentrated broccoli sprout extracts to 97 human type 2 diabetes patients in a 12 - week randomized placebo - controlled trial, obese participants who entered the study with dysregulated disease demonstrated significantly decreased fasting blood glucose levels compared to controls.

A dozen human studies of MDMA, LSD, a powerful African drug called ibogaine and psilocybin, from so - called «magic mushrooms,» are now under way, testing the once - stigmatized drugs as treatments for not only PTSD, but also cluster headaches and addiction, as well as anxiety and depression in cancer patients.

A recent study published in Annals of Neurology reports that healthy human tissue grafted to the brains of patients with Huntington's disease in the hopes of treating the neurological disorder also developed signs of the illness, several years after the graft.

It works in cell studies and in mouse studies, but so far has proved frustratingly ineffective in human patients.

«Data from this study serves as rationale to now include dogs with spontaneous cancers in the advancement and optimization of PMed for human patients,» according to the study, Prospective molecular profiling of canine cancers provides a clinically relevant comparative model for evaluating personalized medicine (PMed) trials.

While nivolumab improved survival rates in the overall study population, it appeared to be most successful in patients whose tumors were positive for the human papillomavirus (HPV).

Prior to the new study, researchers had already developed a more basic type of skin substitute that had been used successfully in human patients, said Takashi Tsuji, a team leader at RIKEN Center forDevelopmental Biology in Japan.

These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed «patient in a dish»); «body on a chip» devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy.

This is the finding of a study in both mice and human patients led by researchers at NYU Langone Medical Center and published online June 9 in the journal Cell.

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

Pre-clinical studies have shown it to be effective in eliminating a number of different kinds of cancers cells, including cancer stem cells from human breast cancer patient biopsies.

Still, Zon cautions that not all human drugs work in zebrafish, so «we need to study a lot more patients to see, in a broad view, how this approach performs.»

«Most previous research into ways of delaying the onset of HD symptoms have focused on studying the mutant protein in cells or in animal models, but the relevance of abnormalities in those systems to what actually happens in patients remains a huge assumption,» says James Gusella, PhD, director of the Center for Human Genetic Research (CHGR) at Massachusetts General Hospital (MGH), corresponding author of the Cell paper.

In this study, researchers took cells from patients with blood cancer MDS and turned them into stem cells to study the deletions of human chromosome 7 often associated with this disease.

In one small study in Japan, human patients with mild cognitive impairments showed significant improvement when given the mushrooms in powdered forIn one small study in Japan, human patients with mild cognitive impairments showed significant improvement when given the mushrooms in powdered forin Japan, human patients with mild cognitive impairments showed significant improvement when given the mushrooms in powdered forin powdered form.

The human UFD1L gene was deleted in all 182 patients studied with 22q11 deletion, and a smaller deletion of approximately 20 kilobases that removed exons 1 to 3 ofUFD1L was found in one individual with features typical of 22q11 deletion syndrome.

«Next steps are to further explore this possibility in human trials in order to assess if it will help patients, but these two drugs make sense from a variety of studies and we find that they act together through multiple mechanisms to control cancer growth in the laboratory.»

In the new study, to test whether the same observation was true in humans, Dr. Rostami and colleagues tested blood samples of patients with MS who had not yet received therapy, and those currently being treated with INF - β, a commonly used therapIn the new study, to test whether the same observation was true in humans, Dr. Rostami and colleagues tested blood samples of patients with MS who had not yet received therapy, and those currently being treated with INF - β, a commonly used therapin humans, Dr. Rostami and colleagues tested blood samples of patients with MS who had not yet received therapy, and those currently being treated with INF - β, a commonly used therapy.

Horvath and Tell's research is the first reported study to compare breast cancer subtypes and gene expression patterns associated with STAT3 in the tumors of human patients.

Scientists want to be able to clone early human embryos, using cells from patients with various diseases, so they can study the diseases in the lab and develop new treatments for them.

Studies of IBD are typically performed using cell culture experiments or animal models, which don't mimic the precise conditions that occur in the gut of human patients.

Animal studies have suggested that overactivation of TLR7 plays a role in lupus, and a gene variant that increases expression of the receptor has been associated with increased lupus risk in human patients.

«The new model enables studies of the complex interactions between host cells, mucus production, and gut microbes in a system that closely mimics the situation in human patients,» Dawson said.

The Thorough QT clinical assessment also has its limitations, as those studies are done in humans and typically require large numbers of patients.

«By helping us understand that lower levels of RNF125 confer resistance to BRAF inhibitors, we have a new strategy to stratify patients for currently approved therapy versus participation for human clinical trials to investigate whether targeting JAK1 will be more effective in patients whose tumors exhibit reduced RNF125,» said Keith T. Flaherty, M.D., associate professor, Harvard Medical School, and director of Developmental Therapeutics, Cancer Center, Massachusetts General Hospital, and co-author of the study.

Published in the Journal of Clinical Investigation, the study collected metabolic data directly from more than 120 human lung cancer patients.

The second cohort of 140 patients with human leukocyte antigen - matched unrelated donor transplants completed enrollment in November 2017, with data expected from this randomized double - blind arm of the study in the next six months.

The goal of the study was to explore whether fecal microbiota from human IBS patients with diarrhea has the ability to influence gut and brain function in recipient mice.

The new study — published October 18, 2016 in the journal Molecular Psychiatry — combined genetic analysis of more than 9,000 human psychiatric patients with brain imaging, electrophysiology, and pharmacological experiments in mutant mice to suggest that mutations in the gene DIXDC1 may act as a general risk factor for psychiatric disease by interfering with the way the brain regulates connections between neurons.

University of Alabama at Birmingham researchers have found that amounts of this microRNA are significantly elevated in the brains of experimental rats with induced depression from corticosterone treatment, in the post-death brains of humans diagnosed with MDD and in peripheral blood serum from living patients with MDD, according to a study by led by Yogesh Dwivedi, Ph.D., the Elesabeth Ridgely Shook Endowed Professor and director of Translational Research, UAB Mood Disorders Program, Department of Psychiatry.

«Once we've shown that this can safely be used in human patients with pulmonary hypertension — and we've got a clinical trial in progress right now — we'll be able to conduct studies of inhaled NO delivered in ambulatory settings, including patients» homes, to treat chronic pulmonary hypertension, right - sided heart failure and chronic obstructive pulmonary disease.»

«The fully defined nature of these synthetic bioengineered hydrogels could make them ideal for use in human patients in the event that HIOs are used for therapy in the future,» said Miguel Quirós, a University of Michigan postdoctoral fellow and co-lead author in the study.

They will study human macrophages and dendritic cells isolated from IBD patients with defective GM - CSF function, «The approach represents a step forward in personalizing how we treat patients with IBD,» said Dr. Colombel.

In previous studies, including recent genome sequencing of cancer patients, human SETD2 has been implicated in several cancer types, especially in renal cell carcinoma — the most common kind of kidney canceIn previous studies, including recent genome sequencing of cancer patients, human SETD2 has been implicated in several cancer types, especially in renal cell carcinoma — the most common kind of kidney cancein several cancer types, especially in renal cell carcinoma — the most common kind of kidney cancein renal cell carcinoma — the most common kind of kidney cancer.

Fugger hopes that his team's study will also help to dispel the notion that genome - wide association studies will never offer much that can be used in patient care (see «Human genetics: Hit or miss»).

«The dog is an invaluable model for exploring hereditary copper - storage diseases, and observations made in this study will benefit both canine and human patient populations.»

She ultimately chose to study leukemia patients» immune responses to bone marrow transplants, an area conducive to translational research in part because the work involves treating patients with human cells, which can be prepared at academic health centers.

Previous studies have shown the drug to be effective at spurring new bone growth in mice and in humans with osteoporosis, and a U-M research team believes that it may spur new growth in brittle bone disease patients as well.

The team at UF's Powell Center for Rare Disease Research and Therapy conducted the first in - human study of gene therapy to treat respiratory dysfunction in patients with infantile onset Pompe.

More animal studies would be needed to move this drug toward human clinical trials, but «what we hope is that we could use this drug to intervene in patients who have had an episode of prolonged seizures and give it to them briefly following that episode to protect them from becoming epileptic,» said James McNamara, M.D., a professor in the departments of neurobiology and neurology at Duke University.

Despite encouraging evidence from animal studies that it clears amyloid from the brain, when it came to clinical improvements in human patients the drug proved no better than placebo in two phase III clinical trials.

So far, the studies of diabetic ulcers and rheumatoid arthritis mentioned above are the only methods to show evidence of clinical effectiveness in human patients.

«Liver cancer is on the rise worldwide, and in human studies we've now seen that patients can progress from fatty liver disease to liver cancer without any middle steps such as cirrhosis,» says David Moore, a professor of molecular and cellular biology, who led the study with Associate Professor Loning Fu, both at Baylor.

The researchers also hope that the algorithm will enable other researchers to study the pathway, possibly leading to a better understanding of its role in human cognition and in patient populations.