Sentences with phrase «studies of animal development»

FP timers should therefore find use in studies of animal development where events like the patterning of nascent tissues and the formation of limbs are correlated with changes in gene expression.

Not exact matches

Animal studies of the chemical have found it has no health effects on reproduction or development at doses up to at least 100 mg per kg of body - weight per day.

The largest prospective nutrition study ever published suggests animal fat may play a role in the development of pancreatic cancer.

He also specified that the purposes were «to perform and foster study and scientific research related to wildlife propagation, growth and development both associated with and disassociated from the raising of livestock and domestic animals.»

While not a lot of research can tell us the effects of BPA on humans, studies on animals suggest it may be dangerous to brain development, the reproductive system, and the immune system.

Animal studies show that low levels of BPA affect the hormones that control the development of the brain, the reproductive system, and the immune system.

When relating the results of animal studies to human infants, important factors to consider include the choice of animal species for study, the stage of development (eg, prenatal or postnatal), and the duration and severity of deficiency or excessive intake.

Animal studies have started to show that the microbiome, from its staging ground in the bowel, can influence the development of its host's brain.

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«Chronic inflammation of the intestine is thought to be caused by abnormal interactions between gut microbes, intestinal epithelial cells and the immune system, but so far it has been impossible to determine how each of these factors contribute to the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the development of intestinal bowel disease,» said Hyun Jung Kim, Ph.D., former Wyss Technology Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the Development Fellow and first author on the study, speaking about the limitations of conventional in vitro and animal models of bacterial overgrowth and inflammation of the intestines.

This study is among several funded under a public - private partnership established in 2008 between NICHD and the WALTHAM Centre for Pet Nutrition, a division of Mars Inc., to establish a human - animal interaction research program to support studies relevant to child development, health, and the therapeutic use of animals.

Nicky Clayton at the University of Cambridge, UK, says the study shows that young chicks are capable of abstract relational thought: «The fact that young chicks can do this suggests this ability is more widespread across the animal kingdom than previously thought, and emerges earlier in development than expected.»

The journal provides cutting - edge research including results from animal models that are likely to apply to patients, studies in human tissue that provide new information about therapies or disease, and innovative reports of drug discovery and development.

In a new animal study, University of Missouri researchers examined how the development of obesity and insulin resistance contribute to bone - fracture risk and whether exercise prevents weight gain and diabetes and protects bone health.

«After our animal studies showed that GM - CSF was important in the development of an MS - like disease, we were excited to see these results confirmed using samples from MS patients in the current study,» says Abdolmohamad Rostami, M.D., Ph.D., Chair of the Department of Neurology at Thomas Jefferson University and director of its neuroimmunology laboratory.

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

Studies with lab animals have linked pyrethroid exposure to damage of the thyroid, liver and nervous system, as well as impairment of behavioral development, changes in the immune system and disruption of reproductive hormones, according to the 2006 EPA review.

protected animals» (i.e., bacteria, fungi, plants, invertebrate animals); studies on vertebrates at early stages of development (before they become?

Along with animal studies, these observations suggest that the balance of bacteria and other microbes help guide immune development — and that when the balance is disrupted, disease may follow.

In past studies to develop a new animal model for the brain events that support motor development, neurophysiologist Martin Garwicz of Lund University in Sweden and his colleagues discovered that the schedules by which ferrets and rats acquire various motor skills, such as crawling and walking, are strikingly similar to each other; the progress simply happens faster for rats.

So in spite of the fact that the coelacanth is a closer relative of land animals, «you're better advised to look at paddlefish, sturgeons, or sharks» to study limb development, says Coates.

Principle investigator Shuk - mei Ho, PhD, director of the Cincinnati Cancer Center, Jacob G. Schmidlapp Chair of Environmental Health and professor at the University of Cincinnati College of Medicine, says that human exposure to BPA is a common occurrence and that animal studies have shown that BPA contributes to development of prostate cancer but that human data are scarce.

Dr. Lyons and his team used zebrafish to study the formation of myelin sheaths by oligodendrocytes because this laboratory animal is transparent at early stages of its development, which allows investigators to directly observe cells within the organism.

«Although this is basic scientific research using animal models, these studies are shedding light on the molecular mechanisms that control male fertility, and are helping us to better understand the causes of many cases of infertility and enabling new horizons to be opened up in the development of therapeutic targets and strategies to combat it,» explained Dr Subirán.

But his lab's animal studies have revealed that asymmetry in an immature egg is important to the development of an embryo.

This area of study has typically involved the dissection of animals at different stages of development to study the formation of organs, and how that process can go wrong.

The development of radiotracers like this could radically change drug development, especially for neurological disorders, which are notoriously difficult to study in animal models.

For example, he says, researchers studying infertility have grafted human testis and ovary cells under the skin of animals in an effort to better understand their development.

«This is the first study to demonstrate that functional muscle cells can be created in a laboratory and restore dystrophin in animal models of Duchenne using the human development process as a guide.»

Policymaking committees should consider giving less weight to food industry - funded studies, and include mechanistic and animal studies as well as studies appraising the effect of added sugars on multiple CHD biomarkers and disease development,» the article concludes.

«This study shows how translational research using basic science techniques in animal models can elucidate the underlying basis of human emotions and reasons for mental disorders, thereby pointing the way for treatment development,» says Jeffrey Lieberman, MD, Lawrence C. Kolb Professor and Chair of Psychiatry at CUIMC.

No previous studies have investigated the direct effect of sugar consumption on the development of breast cancer using breast cancer animal models or examined specific mechanisms, she added.

Animal studies have shown some of the adverse effects of PAE on placental development, but few studies have examined these effects in humans.

This is why studies carried out on animal models can help us to understand the development of the human embryo.

The objective is to support innovative projects dedicated to the development and the study of rare disease models using small animals (mouse model excepted) such as zebrafish, drosophila, nematode, rat and rabbit.

My interest and expertise in immunotherapy started in early 1990s with animal models of IL - 2 and IL - 15 cytokines and natural killer cell development, continued with high dose IL - 2 studies and subsequently Phase I - III trials with both CTLA - 4 and PD1 / PDL -1 checkpoint inhibitors.

Rutaganira expects her studies will spark new understanding of animal development, physiology, and disease.

In addition to a detailed study of the mudskipper and development of a robot model that used the animal's locomotion techniques, the study also examined flow and drag conditions in representative granular materials and applied a mathematical model incorporating new physics based on the drag research.

Researchers from the University of California, San Diego (UCSD) School of Medicine, the Center for Neurologic Study and Isis Pharmaceutical Corporation have designed and tested a molecular therapy in animals that they hope will be a major development in the fight to treat amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease.

Examples of investigations included in this category would involve the study of the structure, physiology, development, and classification of animals, animal ecology, animal husbandry, entomology, ichthyology, ornithology, and herpetology, as well as the study of animals at the cellular and molecular level which would include cytology, histology, and cellular physiology.

The researchers used a technique called RNA interference (RNAi) to screen a group of genes known to be involved in animal development, in order to study the signaling mechanisms that regulate whether the animal would produce a head or tail during regeneration.

His research utilizes molecular biology, cell culture, and animal models to study your body's cannabinoid system in an attempt to further our understanding of Cannabis as a medicine, and possibly lead to the development of new drug compounds.»

Animal studies, whether for the development or production of new medicines, for physiological studies, for studying environmental effects or for the testing of chemicals or new food additives, has to be carried out in compliance with EU legislation.

The work is significant because it lays the groundwork for the development of quantitative models of animal development, enabling the use of mathematical tools more commonly associated with the physical sciences to be applied in biological studies.

The Company features comprehensive infrastructure that enables immediate availability of a broad range of primate models, quick - study start, and innovative research and animal management processes, with flexible and adaptable administrative procedures to expeditiously manage client study protocol development and approval.

In this study, the team delved deep into the nucleus of cells belonging to mouse and zebrafish embryos — two important animal models of embryonic development — in order to determine how the Dll4 gene is turned on.

Studies that would be very difficult to carry out in humans, both from a technical and an ethical point of view can be done with animal models which have proved to be important tools for studying the symptoms, development and treatment of schizophrenia.

Made major contributions to the field of immunology through his studies on immune tolerance in animal models, with particular focus on transplantation tolerance and autoimmunity, in addition to pioneering the use of therapeutic monoclonal antibodies against T cells, resulting in the development of Campath - 1H, the first humanised monoclonal antibody to be used therapeutically.

The protocol was approved by the Institutional Animal Care and Use Committees of the US National Institute of Child Health and Human Development (Animal study protocol number 12 - 059).

The INNF will support projects that cross the spectrum of research and development from animal studies to human clinical trials.