Findings from basic research, such as
studies of cancer cells in the laboratory, can ultimately define research questions to study in humans, such as helping to identify drugs to test in clinical trials.
Two common iron compounds increase the formation of a known biomarker for cancer, according to a new
study of cancer cells from Chalmers University of Technology, Sweden.
Not exact matches
A series
of preliminary Mayo Clinic
studies conducted in 2010 showed promise for the potential use
of a chemical component
of green tea (epigallocatechin gallate) in reducing the number
of cancer cells in patients with chronic lymphocytic leukemia.
Available epidemiologic
studies in humans have «not shown clear evidence
of a relationship between
cell phone use and
cancer,» according to the National Cancer Institute, although this remains a topic of debate among resear
cancer,» according to the National
Cancer Institute, although this remains a topic of debate among resear
Cancer Institute, although this remains a topic
of debate among researchers.
Studies show spending time among trees boosts the number
of «killer
cells» in the immune system that are key to beating infections and fighting
cancer.
Chicago, GenomeWeb — A new
study by researchers from Memorial Sloan Kettering
Cancer Center has demonstrated the predictive power of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor cell detection platform, which could help guide treatment decisions for men with metastatic castration - resistant prostate c
Cancer Center has demonstrated the predictive power
of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor
cell detection platform, which could help guide treatment decisions for men with metastatic castration - resistant prostate
cancercancer.
The biotech specialist said that its updated phase 2 data in a
study of its poziotinib candidate treatment for non-small
cell lung
cancer resulted in a preliminary confirmed objective response rate and potential progression - free survival benefit in patients with the EGFR Exon 20 Mutant form
of the disease.
Studies have shown that their wide array
of antioxidants actually inhibit the growth
of cancer cells, as well as protecting the body from cardiovascular disease — orange vegetables have been shown to provide the most protection against this disease.
Researchers
studied food questionnaires for 335 people with renal
cell carcinoma, the most common form
of kidney
cancer, and 337 healthy controls.
Some researches showed that this little berry provides anti-aging benefits, helps your immune system to operate more efficiently and can even destroy
cancer cells while boosting your energy levels, even if none
of these
studies have scientific confirmation to date.
It offers cardio protection, it helps lower bad cholesterol, it may help prevent the progression
of multiple sclerosis, it has the ability to regenerate brain
cells after a stroke, it has the ability to cross the blood - brain barrier to potentially ward off Alzheimer's disease, apparently it's good at wiping amyloid plaque from the brain (which
studies haves linked to Alzheimer's), it may help to prevent certain types
of cancer, and
studies have shown that it inhibits
cancer cell growth and metastases (meaning it keeps
cancer from spreading).
Another one
of Campbell's
studies, which he chose to omit from his book, showed that wheat gluten can create similar results to the casein protein — suggesting that perhaps a complete amino acid profile, regardless if it's plant or animal sourced, promotes
cell growth, and those can be healthy
cells or
cancer cells.
In a lab
study, an extract
of the leaves stopped the growth and progression
of prostate
cancer cells by up to 75 % in mice.
Cauliflower is full
of sulfur compounds called glucosinolates such as the powerful sulforaphane and isothiocyanates which have been
studied to be very effective for phase II liver detoxification and as
cancer stem
cell neutralizing agents.
This
study found that it promotes the growth
of prostate
cancer cells.
Studies have shown that these
cancer - fighting compounds and enzymes found in broccoli and other cruciferous vegetables may actually prevent the relapse
of certain
cancers by killing
cancer stem
cells.
In 2010, researchers from the University
of Michigan Comprehensive
Cancer Center published a study in the journal Clinical Cancer Research showing that sulforaphane had the ability to kill breast cancer stem cells in mice and in lab cultures, and it also prevented the growth of new tumor
Cancer Center published a
study in the journal Clinical
Cancer Research showing that sulforaphane had the ability to kill breast cancer stem cells in mice and in lab cultures, and it also prevented the growth of new tumor
Cancer Research showing that sulforaphane had the ability to kill breast
cancer stem cells in mice and in lab cultures, and it also prevented the growth of new tumor
cancer stem
cells in mice and in lab cultures, and it also prevented the growth
of new tumor
cells.
While
study results indicated that combining capsaicin with the chemicals «might promote
cancer cell survival,» the report clearly stated that the control group
of mice treated only with capsaicin ``... did not induce any skin tumors...» In addition, the
study repeatedly cited other research
studies in which the anti-
cancer properties
of capsaicin were solidly demonstrated.
But a recent
study found that elevated concentration
of capsaicin, the actual compound which makes hot peppers hot, caused much more prostate
cancer cells to freeze in a non-proliferative phase.
A 2013
study by Cheryl Watson at The University
of Texas Medical Branch at Galveston found that even picomolar concentrations (less than one part per trillion)
of BPS can disrupt a
cell's normal functioning, which could potentially lead to metabolic disorders such as diabetes and obesity, asthma, birth defects or even
cancer.
One
study found that a minuscule amount
of the stuff messes with a
cell in ways that could lead to diabetes, asthma, or
cancer.
Clinical
studies have shown these
cells as effective against several types
of cancer.
Middle - aged people who eat protein - heavy diets are four times as likely to die
of cancer as those who eat only a little protein, according to the
study, which was published in the journal
Cell Metabolism.
«By
studying the ways different proteins like keratin dynamically change within a
cell, we can better understand the progression
of cancers and other diseases,» they say.
«Our
study suggests that epigenetic changes to
cells treated with cigarette smoke sensitize airway
cells to genetic mutations known to cause lung
cancers,» says Stephen Baylin, M.D., the Virginia and D.K. Ludwig Professor for
Cancer Research and professor
of oncology at the Johns Hopkins Kimmel
Cancer Center.
Baylin and Johns Hopkins scientist Michelle Vaz, Ph.D., first author on the
study, suspected that the interplay
of epigenetic and genetic changes may occur when normal lung
cells develop into
cancer, but, Baylin says, the timing
of such changes was unknown.
The
study, led by Dr Len Stephens and Dr Phill Hawkins and published today in the journal Molecular
Cell, reveals why loss
of the PTEN gene has such an impact on many people with prostate
cancer, as well as in some breast
cancers.
By
studying human
cancer cells and animal models
of cancer in the lab, our researchers have shown that loss
of PTEN leads to high levels
of PI (3,4) P2, which could result in hyperactivation
of AKT.
A little -
studied gene may explain how some liver
cancer cells obtain the nutrition they need to proliferate, according to new research from the University
of Maryland.
Even before treatment,
cancer patients in the
study had a small number
of infection - and tumor - fighting T
cells that target these unusual proteins, the researchers found.
The diagnosis
of cancer and
study of disease progression is often accomplished by examining a tumor sample containing many billions or even trillions
of cells.
Cancer cells which arise due to genetic mutations are just such
cells, and there are
studies which suggest that microchimeric
cells may stimulate the immune system to stem the growth
of tumors.
Earlier this year, Feinberg led a
study that considered this view
of epigenetics in metastatic pancreatic
cancer cells.
A new
study has identified a group
of molecules in prostate -
cancer cells that doctors might one day use to distinguish which patients should be treated with radiation therapy if rising PSA levels indicate their
cancer has recurred after surgical removal
of the prostate.
Based on results
of the current
study described in a report online June 18 in the journal
Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian c
Cancer Cell, Johns Hopkins researchers say they are planning a phase I clinical trial to test the paclitaxel - fostamatinib combination therapy in patients with recurrent advanced ovarian
cancercancer.
Chemotherapy drugs designed to kill tumors may actually encourage ovarian
cancer by stimulating the growth
of cells that give rise to the malignancy, a new
study finds.
The other significant finding
of the
study, says Garrett Jenkinson, Ph.D., assistant research scientist at the Johns Hopkins Whiting School
of Engineering who carried out much
of the analyses, was that this variability goes haywire in
cancer cells, which may display significant regional differences in methylation stochasticity compared to normal
cells.
Fostamatinib's effect on microtubules seems to increase the stabilizing effect
of paclitaxel, even in resistant
cells, which in turn may prevent
cancer cells from proliferating, says Yu Yu, Ph.D., a postdoctoral fellow at the Johns Hopkins University School
of Medicine and co-author
of the
study.
«Overall, our
studies show that by using modified techniques we will be able to observe non-uniform
cancer cells, regardless
of their origin,» Polo - Parada said.
The idea to specifically
study this group
of patients was based on groundbreaking research Garon published in the New England Journal
of Medicine last year, which found that among patients who received pembrolizumab, those with PD - L1 expression on at least 50 percent
of their
cancer cells showed the longest survival and disease control.
Protein expression in these glioblastoma
cells more closely mimicked that in real
cancer cells than in 2D cultures
of cells, indicating that this method could be used to
study cancer (Nature Nanotechnology, DOI: 10.1038 / nnano.2010.23).
The protein puts the immune system's brakes on, keeping its T
cells from recognizing and attacking
cancer cells, said Dr. Antoni Ribas, the
study's principal investigator and a professor
of medicine in the division
of hematology - oncology at the David Geffen School
of Medicine at UCLA.
Led by researchers at the Ohio State University Comprehensive
Cancer Center — Arthur G. James
Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James), the retrospective
study suggested that a pattern
of molecules called microRNA (miRNA) in tumor
cells might predict patients» response to radiation therapy.
The
study, published April 4 in the journal The Lancet Oncology, focused on non-small
cell lung
cancer, which is the most common form
of lung
cancer.
Dr Claudia Wellbrock,
study author and
Cancer Research UK scientist at The University of Manchester and a member of the Manchester Cancer Research Centre, said: «We used to think that cancer cells spread by first specialising in invading other parts of the body and then change in order to grow ra
Cancer Research UK scientist at The University
of Manchester and a member
of the Manchester
Cancer Research Centre, said: «We used to think that cancer cells spread by first specialising in invading other parts of the body and then change in order to grow ra
Cancer Research Centre, said: «We used to think that
cancer cells spread by first specialising in invading other parts of the body and then change in order to grow ra
cancer cells spread by first specialising in invading other parts
of the body and then change in order to grow rapidly.
Dr. McCabe said nanoparticles are a leading - edge technology also being
studied for delivery
of drugs for other conditions, such as
cancer, heart disease, and bacterial infections, in order to target specific
cells to reduce toxicity and side effects
of those medications and to make them more effective.
In the
Cell study, Dr. Massagué, with Fellow Manuel Valiente, PhD, and other team members, found that in mouse models
of breast and lung
cancer — two tumor types that often spread to the brain — many
cancer cells that enter the brain are killed by astrocytes.
Now a University
of Colorado
Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resis
Cancer Center
study published online ahead
of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use
of retinoic acid or other retinoids against some breast
cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast
cancer cells may have been pushed past an important tipping point that offers retinoic acid resis
cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.
The researchers
studied triple - negative breast
cancer cells, which grow and spread faster than most other types
of cancer cells.
Contrary to current research this new
study found that LKB1, a molecule that regulates the metabolism
of many adult
cells, is an important molecule in the
cancer's promotion and survival.