African populations harbour the greatest genetic diversity and have the highest per capita health burden, yet they are rarely included in large genome
studies of disease association.
Not exact matches
The American Beverage
Association dismissed the
study in a statement, saying it did «not show that consuming sugar - sweetened beverages causes chronic
diseases and the authors themselves acknowledge that they are at best estimating effects
of sugar - sweetened beverage consumption.»
To date, the majority
of prospective
studies have found no significant
association between egg consumption and risk
of coronary heart
disease or stroke.
While only about one half
of 1 percent
of Americans actually suffer from celiac
disease — which involves damage to the intestines that has been related to gluten — the number
of people who are following gluten - free diets far outstrips that number, perhaps out
of a public belief that a gluten - free diet is generally healthier, according to a 2016
study published by the American Medical
Association.
A 2010 meta -
study published in the American Journal
of Clinical Nutrition looked at almost 350,000 people over a 23 year period and found no
association between saturated fat and heart
disease.
A recent systematic review and meta - analysis reported no significant
association between the consumption
of saturated fatty acids (SFAs) and the risk
of coronary heart
disease (CHD)(1), but the
study failed to specify the replacement macronutrient for saturated fat.
There is a bit
of a debate about the role
of animal protein in diet, mostly about the
studies that only show
associations of protein and
disease and not hard evidence
of causality.
Sanders, D.S., M.J. Carter, D.P. Hurlstone, et al., «
Association of Adult Coeliac
Disease With Irritable Bowel Syndrome: A Case - Control
Study in Patients Fulfilling ROME II Criteria Referred to Secondary Care,» Lancet, 358:1504 - 1508, 2001.
In an ideal world, systematic reviews provide access to all the available evidence on specific exposure —
disease associations, but publication bias related to authors» conflicts
of interest may affect the reliability
of the conclusions
of such
studies.
We included prospective
studies that provided hazard ratios (HRs) with 95 % confidence intervals (CI) for at least three categories (including the reference group)
of milk consumption in relation to mortality from all causes, overall cardiovascular
disease, or overall cancer, We omitted
studies that only reported results for total milk products or combined non-fermented and fermented milk because non-fermented and fermented milk may have different
associations with mortality.
Epidemiological
studies have observed a negative
association between tomato intake and the incidence
of cardiovascular
disease.
Sources tell Press
Association Sport that a major
study into whether footballers are at greater risk
of degenerative brain
disease is set for launch in the next few weeks with the appointment
of a research group to undertake the most comprehensive
study of its kind, jointly commissioned by the Football
Association and Professional Footballers»
Association.
One
study finds an
association with
disease x, but not y or z, another finds one with y but not x. None
of these
studies are able to fully control for the critically important confounding variable
of maternal health, and none
of the decent quality ones have demonstrated a large difference in risk.
Additional
studies are needed to assess the
associations of breastfeeding duration with the risks
of infectious
diseases beyond the age
of 6 months.
In multiple
studies, lactation is associated with reduced maternal risk
of type 2 diabetes mellitus.12, 22 Several
studies have found differences in diabetes prevalence among postmenopausal women.22, 23 However, the only
study to measure incident
disease found that the
association between breastfeeding and incident type 2 diabetes mellitus disappeared after 15 years after a woman's last birth.12 Thus, we limited the effect
of lactation on type 2 diabetes mellitus accordingly.
Of note, our models may underestimate the true maternal costs of suboptimal breastfeeding; we modeled the effects of lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and M
Of note, our models may underestimate the true maternal costs
of suboptimal breastfeeding; we modeled the effects of lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and M
of suboptimal breastfeeding; we modeled the effects
of lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some studies have found an association between lactation and rates of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and M
of lactation on only five maternal health conditions despite data linking lactation with other maternal health outcomes.46 In addition, women in our model could not develop type 2 diabetes mellitus, hypertension, or MI before age 35 years, although these conditions are becoming increasingly prevalent among young adults.47 Although some
studies have found an
association between lactation and rates
of postmenopausal diabetes22, 23 and cardiovascular disease, 10 we conservatively limited the duration of lactation's effect on both diabetes and M
of postmenopausal diabetes22, 23 and cardiovascular
disease, 10 we conservatively limited the duration
of lactation's effect on both diabetes and M
of lactation's effect on both diabetes and MI.
Breastfeeding is associated with about 10 % lower maternal risk
of several major cardiovascular
diseases (CVDs) in later life, and the magnitude
of the inverse
association was stronger among those with a longer duration
of breastfeeding, according to a large, prospective, observational
study among Chinese women.
Funnel plot
of precision estimates [calculated by using the inverse
of the SE
of ln (odds ratio); ie, the higher the estimate, the more precise the
study] from
studies that explored the
association between breastfeeding and Crohn
disease against their odds ratio.
Previously Bao and her colleagues observed an
association between increased nut consumption and reduced risk
of major chronic
diseases and even death, but few prospective cohort
studies had examined the link between nut intake and inflammation.
«While MR
studies have been successful in solving the causal relevance
of major lipids in coronary heart
disease (LDL - C and TG, yes, and HDL - C, no), it seems that other approaches are required to further evaluate the causal relevance
of each
of these lipid fractions in
association with T2D.
«Previous
studies have demonstrated an
association between stress and skin symptoms, but those
studies relied on small patient samples, did not use standardized tools, are anecdotal in nature, or focused their analyses on a single skin
disease,» says Gil Yosopovitch, MD, Chair
of the Department
of Dermatology at LKSOM, Director
of the Temple Itch Center, and corresponding author
of the
study.
In the second
study, Dr. McCoy and colleagues demonstrated the application
of this new method to examine the
association between symptom dimensions and common genetic variation in psychiatric
disease.
Using an approach called a genome - wide
association study, researchers scanned complete sets
of DNA in thousands
of participants, looking for small variations that appear more often in people with the
disease than in healthy individuals.
The authors conclude: «The findings from this large prospective
study show that the
association between body size and prostate cancer is complex and varies by
disease aggressiveness; men who have greater adiposity have an elevated risk
of high grade prostate cancer and prostate cancer death.»
The Immunochip for fine - mapping is an important tool for conducting genome - wide
association studies of the genetic components
of disease.
This synthetic eye could be used to
study and test treatments for eye
diseases, researchers reported February 16 in a news conference at the annual meeting
of the American
Association for the Advancement
of Science.
A new
study published in the Journal
of the American Medical
Association found depressed patients with chronic kidney
disease did not benefit from a common antidepressant.
New research published in Diabetologia (the journal
of the European
Association for the
Study of Diabetes) shows that age (or age at diagnosis) and duration
of diabetes
disease are linked to the risk
of death and marcovascular complications (those in larger blood vessels), whereas only diabetes duration is linked to the risk
of microvascular complications (in smaller blood vessels such as those in the eyes).
And a 2007
study published in the European Journal
of Epidemiology followed 1,500 older people for five years and found no
association between urinary sodium levels and the risk
of coronary vascular
disease or death.
If the
association holds up in larger
studies, Chatila says, doctors could use the information to sort out which mutation — or combination
of mutations — leads to different kinds
of allergic
diseases.
Based on these points, Dr. Canli suggests a major research step would be to conduct large - scale
studies with depressed patients, controls, and infectious -
disease related protocols to determine the
association or causal nature
of infectious
disease and depression.
A growing number
of epidemiologic
studies have suggested an
association between sedentary behavior and chronic
diseases including obesity, diabetes, insulin resistance, metabolic syndrome, cardiovascular
disease, cancer, and even death that is distinct from those related to a lack
of physical activity.
The Children's Heart Failure
Study Group
of the Canadian Cardiovascular Society, in collaboration with the Canadian Pediatric Cardiology
Association, has developed new guidelines to assist practitioners in primary care and emergency departments to recognize and successfully manage heart failure in children with undiagnosed heart
disease and symptoms
of possible heart failure.
Several previous
studies have found an
association between increasing nut consumption and a lower risk
of diseases such as heart
disease, type 2 diabetes, colon cancer, gallstones, and diverticulitis.
Older people who have had strokes or who have vascular
disease are at risk
of stroke both immediately after cardiac surgery and during the following two years, according to a new
study in CMAJ (Canadian Medical
Association Journal).
While previous
studies have linked skipping breakfast to coronary heart
disease risk, this is the first
study to evaluate the
association between breakfast and the presence
of subclinical atherosclerosis.
«Physical inactivity is associated with morbidity and mortality in COPD, but the
association between objectively measured physical activity and other
disease components over time has not been well
studied,» said lead author Benjamin Waschki, MD,
of the Pulmonary Research Institute at LungenClinic in Grosshansdorf, Germany.
«Our approach is likely to «revive» genome - wide
association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range
of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»
Schwartz and his colleagues
study a host
of other
diseases, such as diabetes, to see what the predictive capabilities and
associations of Twitter can reveal.
International guidelines from the American
Association for the
Study of Liver
Disease / Infectious Diseases Society
of America, the European
Study for the
Association of the Liver, the International Network for Hepatitis in Substance Users, and the World Health Organization, now all recommend treatment for hepatitis C infection among people who use drugs.
«These restrictions also are in conflict with new HCV treatment guidelines from the American
Association for the
Study of Liver
Disease (2015), which explicitly state that active injection drug users should be prioritized for treatment in part because
of the risk
of transmission to susceptible injection partners.»
«Short duration
of breastfeeding and maternal obesity linked to fatty liver in adolescents: Novel
study finds evidence for
association between breastfeeding duration and maternal obesity and development
of nonalcoholic fatty liver
disease in adolescents, reports the Journal
of Hepatology.»
Limitations
of the
study include that people with severe Parkinson's
disease were not included, which could affect the ability to detect an
association between
disease severity and caffeine levels.
«When we examined the
associations of the three food categories with heart
disease risk, we found that healthy plant foods were associated with lower risk, whereas less healthy plant foods and animal foods were associated with higher risk,» said Ambika Satija, ScD, a postdoctoral fellow at the Harvard T.H. Chan School
of Public Health in Boston and the
study's lead author.
Although some
studies have found sauna bathing to be associated with better cardiovascular and circulatory function, the
association between regular sauna bathing and risk
of sudden cardiac death (SCD) and fatal cardiovascular
diseases (CVD) is not known.
Eating behaviours
of preschoolers may be associated with risk
of cardiovascular
disease in later life, suggests a
study published in CMAJ (Canadian Medical
Association Journal).
Migraine has been consistently linked with an increased risk
of stroke, but few
studies have shown an
association of migraine with cardiovascular
diseases and mortality.
So a team
of US and German researchers carried out a large prospective
study to evaluate
associations between migraine, cardiovascular
disease and mortality.
Repeatedly losing and regaining weight, known as weight cycling or yo - yo dieting, may increase the risk
of death from heart
disease among postmenopausal women who were
of normal weight at the start
of the
study, according to research presented at the American Heart
Association's Scientific Sessions 2016.
Both spouses and first - degree relatives
of patients with celiac
disease are at increased risk
of nonceliac autoimmune
disease, according to a
study in the July issue
of Clinical Gastroenterology and Hepatology, the official clinical practice journal
of the American Gastroenterological
Association.