Dr. Fahey has published
studies on chemotherapy for lymphoma and osteosarcoma.
Not exact matches
«The network recognizes patterns,» says M. Rizwan Sohail, an infectious disease expert at Mayo Clinic and lead author of the
study, presented at the Interscience Conference
on Antimicrobial Agents and
Chemotherapy in San Francisco in September.
This recommendation is based
on a separate
study published in The Lancet, for which Garon was the senior author, showing longer survival than
chemotherapy among patients with any positive staining for PD - L1.
In addition,
on average, patients receiving nivolumab reported that their quality of life remained stable or improved throughout the
study, while those in the
chemotherapy group reported a decline.
Last month, Biopure launched a revamped clinical development program, emphasizing testing in Europe, with three phase II clinical trials planned for 2008 to
study the impact of its product
on heart attack patients,
chemotherapy patients with anemia and the terminally ill.
Prior
studies on the diet have shown potential for alleviating symptoms of the neurodegenerative disease multiple sclerosis, increasing the efficacy of
chemotherapy for cancer treatments, and decreasing visceral fat.
«There is currently no method that can predict treatment outcome of
chemotherapy early
on in treatment, so this is a major advance,» says Hielscher, co-leader of the
study, who is also a member of the Breast Cancer Program at the Herbert Irving Comprehensive Cancer Center at NewYork - Presbyterian / Columbia University Irving Medical Center.
An early - stage clinical
study by another institution, published in the Lancet Oncology in May 2016, combined
chemotherapy with an experimental drug that blocks CCR2, a receptor
on monocytes and macrophages whose activation stimulates these cells to infiltrate tumors.
This
study of 37 patients (24 men and 13 women, ages 51 to 80) who have never been treated with
chemotherapy found direct correlation of the amount of cfDNA with tumor metabolism (based
on PET - derived parameters), but not with metabolic tumor volume.
Prior
studies that examined the impact of cancer treatment decisions
on employment showed that patients who received
chemotherapy were most likely to experience longer disruptions in or loss of employment, but changes in breast cancer management in recent years have shifted recommendations away from
chemotherapy for early stage breast cancer.
Prof Fortunato Ciardiello from Seconda Università degli Studi di Napoli, Italy, presented results from the CAPRI - Goim
study on the efficacy of cetuximab plus FOLFOX
chemotherapy as second - line treatment for patients with mCRC that progressed following FOLFIRI
chemotherapy and cetuximab.
The strong response to this new use of enzalutamide shows that it can provide a viable, less toxic alternative to
chemotherapy in staving off the disease in men who aren't responding to standard first line hormonal treatments,» said Tomasz Beer, M.D., the lead author
on the
study and deputy director of the Knight Cancer Institute at OHSU.
Patients with metastatic colorectal cancer (mCRC) that are mutation - free in the KRAS, NRAS, BRAF and PIK3CA genes showed significant benefit from continuing anti-epidermal growth factor receptor (EGFR) therapy beyond progression following first - line
chemotherapy and an anti-EGFR monoclonal antibody, according to
study results (1) presented today at the ESMO 17th World Congress
on Gastrointestinal Cancer in Barcelona, Spain.
«It's important to understand the mechanisms of action of
chemotherapy on spermatogenesis to help clinicians make informed decisions
on adjusting treatment, reducing side effects, and better advising patients
on family planning,» says INRS's Dr. Géraldine Delbès, reproductive toxicology specialist and the author in charge of this
study.
«Since 95 percent of cancer patients still get chemo, we realized we could make a major impact
on cancer treatment by helping clinicians prescribe the right
chemotherapy drug,» said Sourav Bandyopadhyay, PhD, a professor of bioengineering and therapeutic sciences in UCSF's Schools of Pharmacy and Medicine and senior author
on the new
study.
He continued: «This was the first phase III
study to assess whether the second generation ALK inhibitor ceritinib was superior to
chemotherapy upon progression
on crizotinib therapy in NSCLC.»
We would like to
study the reaction between
chemotherapy drugs and other substances and coatings used
on medical equipment,» Wells concludes.
Commenting
on the trial, Dr Alice Shaw, director of thoracic oncology at the Massachusetts General Hospital Cancer Centre in Boston, US, said: «This is the first randomised
study to examine how a second generation ALK inhibitor compares to standard second line
chemotherapy in ALK positive patients who failed the standard first line therapy, which currently is crizotinib.»
Researchers from NIH's National Institute of Allergy and Infectious Diseases (NIAID) presented the preliminary
study results at the Interscience Conference
on Antimicrobial Agents and
Chemotherapy (ICAAC) meeting in Denver in September 2013.
«A traditional view of
chemotherapy is that you try to completely kill cancer cells and destroy tumors,» said Arup Indra, an associate professor in the OSU College of Pharmacy and one of the lead authors
on the
study.
Commenting
on the
study, Dr Andres Poveda, Head of the Gynecological Oncology Clinic at Fundación Instituto Valenciano de Oncología, Valencia, Spain, who was not involved in the research, said the CIRCCa
study is the second recent trial to show the benefit of adding an antiangiogenic drug to
chemotherapy in cervical cancer.
This
study is the first to provide clear evidence of a strong interaction between
chemotherapy and radiotherapy
on risk of subsequent stomach cancer.
«The focus of
chemotherapy and existing standard - of - care is
on killing cancer cells but instead we took a completely different approach which changes the environment the cancer cells live in,» said Mick Bhatia, director and senior scientist with the McMaster Stem Cell and Cancer Research Institute, who led the group that performed the
study.
But this
study took a different approach — rather than just focusing
on antibiotic - resistant strains, the
study tapped into an unbiased collection of 1509 E. coli, the majority of which were from the British Society of Antimicrobial
Chemotherapy Bacteraemia Surveillance programme collected over 11 years from across England.
The Yale - led
study performed whole exome sequencing ¬ — a technique for sequencing all the expressed genes in a genome ¬ —
on TNBC tumors to identify mutations in specific genes or pathways that may indicate response or resistance to the standard of care, which is anthracycline / taxane (ACT)
chemotherapy.
«Based
on this research, we are now conducting a first - in - human
study combining the PARP inhibitor with radiation and
chemotherapy in patients with locally advanced pancreatic cancer, with an ultimate goal of improving survival rates and treatment outcomes,» said Tuli.
In a
study appearing in the May 3 issue of JAMA, Pascal Hammel, M.D., of Beaujon Hospital, Clichy, France and colleagues assessed whether chemoradiotherapy improves overall survival of patients with locally advanced pancreatic cancer controlled after 4 months of gemcitabine - based induction
chemotherapy, and assessed the effect of erlotinib
on survival.
Final results of a randomised phase III
study on adjuvant
chemotherapy with 5 FU and levamisol in colon and rectum cancer stage II and III by the Norwegian Gastrointestinal Cancer Group.
The results suggest that assessing baseline QoL in women with PRR - ROC might help identify which patients are unlikely to benefit from palliative
chemotherapy, said lead
study author Felicia Roncolato, MBChB, FRACP, of St. George Hospital in Sydney, Australia,
on behalf of the Gynecologic Cancer Intergroup Symptom Benefit Group.
Two main examples of these translational
studies we participated
on can be exposed: The first Cog - Age clinical
study (Pr F. Joly, Baclesse Caen) showed that cognitive decline can be detected 6 months after
chemotherapy in breast cancer elderly patients.
Adding total body irradiation to preparative lymphodepletion
chemotherapy prior to the adoptive cell transfer of tumor - infiltrating lymphocytes (TILs) had no effect
on tumor regression in patients with metastatic melanoma, according to the results of a
study published in the Journal of Clinical Oncology.
In 2005, the
chemotherapy temozolomide (Temodar ®) was approved to treat newly diagnosed GBM patients based
on a randomized phase III clinical
study that showed that it added 2.5 months to the median survival of patients.
The
study, published in November 2016 in The Lancet Oncology and presented with updated outcomes at the October 2017 World Conference
on Lung Cancer in Yokohama, Japan, reported that 57 percent of patients receiving the combination therapy responded to treatment, whereas only 31 percent responded to
chemotherapy alone.
In Vitro
Studies On The Impact Of TLR2 Agonists
On The Cytotoxic Potential Of
Chemotherapy And Immune Responses In pre-B Acute Lymphoblastic Leukemia (ALL).
Study of the effect of valproate
on pulmonary cancer cells, in combination with
chemotherapy agents.
Throughout his career, Cole also has teamed with Rutgers Cancer Institute investigators
on studies exploring
chemotherapy resistance, alternative therapies for children with acute lymphoblastic leukemia, and improved therapies for adolescents and young adults with relapsed or refractory Hodgkin lymphoma.
Patients put
on a tight scalp cooling cap for a half hour before
chemotherapy, and leave it
on for 90 minutes to 120 minutes afterward, according to the two
studies.
A 2015 article in the International Journal of Biochemistry and Cell Biology sums up the findings of multiple
studies on ketogenic diets and cancer with the following: «there is increasing evidence that the ketogenic diet may also be beneficial as an adjuvant cancer therapy by potentiating the antitumor effect of
chemotherapy and radiation treatment.»
Studies on calorie restriction through short - term fasting just before
chemotherapy — defined as a complete lack of food and caloric beverages (noncaloric beverages such as water are allowed) for 72 hours or less — has demonstrated a wide range of beneficial effects.
A very recent
study on the effects of fasting and calorie restriction
on cancer patients receiving
chemotherapy found that calorie restriction and fasting seem to trigger a protective cellular mechanism so strong, that it would be difficult to achieve such an effect with potent drug intervention.
Lin, Y. S., Lin, L. C., and Lin, S. W. Effects of zinc supplementation
on the survival of patients who received concomitant
chemotherapy and radiotherapy for advanced nasopharyngeal carcinoma: follow - up of a double - blind randomized
study with subgroup analysis.
Dying at home, avoiding the intensive care unit, and forgoing
chemotherapy and feeding tubes in the last week of life are all associated with a better quality of life among end - stage cancer patients, according to the
study, which was based
on a detailed survey of 396 patients and their caregivers.
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