And while she'd like to see double - blind
studies on curcumin in the future, she says the compound still holds a lot of promise.
There's been a lot of
study on Curcumin's effect on inflammation [1].
Not exact matches
There have also been
studies it research the effects
curcumin has
on boosting the body's own antioxidants.
While
curcumin has been shown to prevent depression, reverse liver damage, and prevent and treat Alzheimer's, my mom can go ahead and unarch that eyebrow — the majority of the
studies showing the dramatic results have only been done
on mice and rats.
This
study investigated the influence of chronically administered
curcumin on normal ageing - related parameters: lipid peroxidation, lipofuscin concentration and intraneuronal lipofuscin accumulation, activities of the enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx), and Na (+), K (+), - adenosine triphosphatase (Na (+), K (+), - ATPase) in different brain regions (cerebral cortex, hippocampus, cerebellum and medulla) of 6 - and 24 - month - old rats.
In the present
study, we evaluate the effect of
curcumin derivatives
on Aβ production in... human neuroblastoma SH - SY5Y cells and in CHO cells which stably express human AβPP (CHO - AβPP).
In the present
study, we evaluate the effect of
curcumin derivatives
on Aβ production in
But the content of
curcumin in turmeric isn't that high and most of the
studies conducted
on turmeric have used turmeric extracts which consist mainly of
curcumin itself.
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The vast majority of clinical
studies on turmeric haven't used turmeric powder, but have instead used
curcumin, a constituent of turmeric.
In fact in a recent
study in 2016
on the «Strong Anti-inflammatory Effects of
Curcumin» by Vetivicka and Vetivickova, demonstrated that only
Curcumin C3 Complex had both anti-inflammatory and immunological activity in comparison to four other brands of generic 95 percent curcuminoids in both vitro and vivo testing.
This
study centers
on curcumin, a main ingredient in turmeric that has been made use of in «Ayurvedic» or traditional Indian medicine for centuries as an anti-inflammatory and treatment for symptoms associated with irritable bowel syndrome and other ailments.
But, recent
studies highlight the promising effects of
curcumin and other Chinese medical botanicals
on these particular cancer cells.
A
study in 2012
on both men and women, found that three servings of turmeric per day (22.1 mg
curcumin per dose) led to a reduction in systolic blood pressure (3).
Another
study also found that
curcumin had a significant effect
on «several biomarkers that may be associated with its antidepressant mechanisms of action» (17).
A
study on obese men and women found that 1g per day of
curcumin over a period of 1 - 6 months led to a reduction in anxiety (20).
They go
on to point out that just because some
studies have found no toxicity in short term
studies on humans it doesn't mean that
curcumin is necessarily safe.
UCLA researchers just wrapped up a
study on whether Alzheimer's patients improve from taking
curcumin.
Since 1960, there have been over 2,000 published
studies referencing
curcumin's impact
on depression or major depressive disorder.
The U.S. National Institutes of Health counts 135 registered trials of
curcumin in the last 15 years, according to the
study authors, but not one double - blind, placebo - controlled clinical trial
on curcumin can support all of the benefits we've been attributing to it, and when it comes to research that seemed to prove
curcumin's effects
on pancreatic and colon cancers, Alzheimer's disease, and radiation - induced rashes, it seems that the supposed benefits are all cracked up.
Following
on from my last post, I have been questioning myself more about optimal dosages for supplementation of
curcumin, particularly in light of such
studies whereby «high» amounts of the compound are tolerated with minimal to zero toxicity reported.
Curcumin, the bright yellow chemical found in turmeric,
on the other hand, significantly supports CYP1 detoxification but can inhibit it at much higher doses — at least in petri dish and animal
studies.39, 40 As is usually the case with our physiology, it is far from straightforward, as some healthy sources of fruits and vegetables can actually inhibit CYP1, but generally these foods support detoxification by interacting with multiple CYP enzymes.
As of June 2015, there were 116 clinical trials evaluating the possible anti-disease effect of
curcumin in humans, including
studies on cancer, gastrointestinal diseases, cognitive disorders, and psychiatric conditions.
«Given the long and established history of
curcumin as a spice and herbal medicine, its demonstrated chemopreventive and therapeutic potential, and its pharmacological safety in model system,
curcumin, the bioactive extract of
curcumin, promises a great future in human clinical
studies designed to prevent and / or delay age - related diseases,» explained the authors of a review
on these and other animal
studies involving
curcumin.
A
study back in ’87 investigated the effects of
curcumin on the mutagenicity — the DNA - mutating ability — of several toxins.
* Meriva is the most clinically
studied curcumin on the market with 29x greater absorption than ordinary
curcumin.
One
study shows that
curcumin turns
on a key gene signal involved with nerve protection, which boosts antioxidant enzymes in the brain and helps to prevent neurodegeneration.
I started after reading about a very small (double blind placebo
study)
on curcumin's effect
on depression and was interested to read in the article it seemed to have a very good effect for atypical depression.
In a recent trial for ulcerative colitis, a multicenter, randomized, placebo - controlled, double - blind
study found that more than 50 percent of patients achieved remission within just one month
on curcumin compared to none of the patients who received the placebo.
The
study was in vitro, so the benefits aren't proven
on a living human; p.acnes living
on human skin may be stronger, the
curcumin may not impact them as strongly, other bacteria may defend p.acnes — who knows.
A number of laboratory
studies on cancer cells have shown that
curcumin does have anticancer effects.
Curcumin has also been linked to supporting brain function in a study on aging rats, which found that curcumin supplementation enhanced memory and neuroprotective pro
Curcumin has also been linked to supporting brain function in a
study on aging rats, which found that
curcumin supplementation enhanced memory and neuroprotective pro
curcumin supplementation enhanced memory and neuroprotective properties.
(40) For instance, in a
study on mice,
curcumin produced more serotonin in both the frontal cortex and hippocampus.
When it comes to human trials, a clinical
study on 44 male smokers with lesions in the colon found that the subjects who took 4 grams of
curcumin per day for 30 days reduced their number of lesions by 40 %.
Studies show that
curcumin works by suppressing inflammation and having a positive impact
on how the body stores fat — reversing insulin resistance and other symptoms associated with obesity.
Another clinical
study on the bioavailability of curcuminoids investigated the effects of a patented formulation, BCM - 95 ® CG (Biocurcumax ™)-- a highly - absorbent, synergistic blend of
curcumin and turmeric essential oil derived from 100 % pure turmeric (with no additional ingredients or cofactors)--
on a human volunteer group.
Curcumin is one of the most heavily
studied compounds found in one of the most
studied herbs
on the planet, turmeric.
There are hundreds of other
studies that have shown that
curcumin turns
on natural apoptotic (cell suicide) switches in cancer cells (8).
Yu, Y., Hu, S. K., and Yan, H. [The
study of insulin resistance and leptin resistance
on the model of simplicity obesity rats by
curcumin].
A novel investigative
study published in the Nov 2014 issue of the Journal of Endocrinology looked at the effects of
curcumin on insulin - producing cells within the pancreas called Beta cells (or B - cells) and Islet cells, in relation to imbalanced blood sugar.
In short, we are delighted to see great
studies on the health benefits of
curcumin, yet since we are most interested in the spice itself (turmeric) and the potential benefits of this spice in recipes, we also realize that some of the research
on curcumin doesn't easily translate into these more practical kitchen and recipe applications.
Given this set of events, it has not been surprising to see more animal
studies focusing
on the ability of
curcumin and turmeric to potentially improve chronic neurodegenerative problems including Alzheimer's disease.
Studies have shown that
curcumin has a similar effect as Prozac
on patients suffering from depression, mood swings, anxiety, and stress.
However,
curcumin is poorly absorbed into the bloodstream
on its own, and in the
studies that gave the higher amounts, the text explained they did so specifically because it is so poorly absorbed.