Pembrolizumab, or pembro, an immunotherapy drug that unmasks cancer cells and allows the body's own immune system to help destroy tumors, appears to be safe in treating lung cancers, according to
a study by Cancer Treatment Centers of America ® (CTCA) at Western Regional Medical Center (Western) in Goodyear, Arizona.
Not exact matches
Chicago, GenomeWeb — A new
study by researchers from Memorial Sloan Kettering
Cancer Center has demonstrated the predictive power of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor cell detection platform, which could help guide treatment decisions for men with metastatic castration - resistant prostate c
Cancer Center has demonstrated the predictive power of an AR - V7 protein expression test using Epic Sciences» non-EPCAM-based circulating tumor cell detection platform, which could help guide
treatment decisions for men with metastatic castration - resistant prostate
cancercancer.
Cancer treatment guidelines produced
by the US National Comprehensive
Cancer Network (NCCN) are often based on low quality evidence or no evidence at all, finds a
study published
by The BMJ today.
A one - two combo punch using two currently available drugs could be an effective
treatment for the majority of lung
cancers, a
study by scientists with UT Southwestern's Simmons
Cancer Center shows.
Called the Canakinumab Anti-inflammatory Thrombosis Outcomes
Study (CANTOS) and funded
by the drug giant Novartis, the trial also found fewer cases of lung
cancer in those on the
treatment, rekindling basic research findings hinting that the same inflammatory pathway may initiate or spur the growth of such tumors.
A
study led
by The University of Texas MD Anderson
Cancer Center has opened up yet another avenue for understanding the biological reasons why some people live longer or respond better to
treatment — RNA editing events.
GIS's DNA analysistechnique has allowed the researchers to further
study the biology of Opisthorchis viverrini to understand the cause and the eventual development of
treatments for bile duct
cancer, a condition caused
by the parasite.
In the
study published in the journal Science Signaling, the team led
by LLuís Espinosa, investigator of IMIM's research group into stem cells and
cancer, have shown that inhibition of endosomal activity is a potential therapeutic strategy for the
treatment of
cancers with the BRAF mutated gene.
The new doubts over psoralen stem partly from a
study funded
by the Brussels - based European Organization for Research and
Treatment of
Cancer.
«
By understanding how stress accelerates invasion in aggressive breast tumor cells, this work will inform future
studies into whether beta - blockers could be a useful adjuvant therapy in the
treatment of some aggressive breast
cancers.»
«Other
studies have looked at racial disparities in
treatment and still others have focused on racial differences in survival rates of
cancer patients, but our research attempted to go further by demonstrating the impact of race - based inequalities in cancer treatment on survival rates of black colorectal cancer patients,» said James D. Murphy, MD, MS, assistant professor and chief of the Radiation Oncology Gastrointestinal Tumor Service at UC San Diego Moores Cancer C
cancer patients, but our research attempted to go further
by demonstrating the impact of race - based inequalities in
cancer treatment on survival rates of black colorectal cancer patients,» said James D. Murphy, MD, MS, assistant professor and chief of the Radiation Oncology Gastrointestinal Tumor Service at UC San Diego Moores Cancer C
cancer treatment on survival rates of black colorectal
cancer patients,» said James D. Murphy, MD, MS, assistant professor and chief of the Radiation Oncology Gastrointestinal Tumor Service at UC San Diego Moores Cancer C
cancer patients,» said James D. Murphy, MD, MS, assistant professor and chief of the Radiation Oncology Gastrointestinal Tumor Service at UC San Diego Moores
Cancer C
Cancer Center.
Dr. Tordjman and her colleagues
studied the effect of radioactive iodine
treatment on the ovarian reserve of women treated for differentiated thyroid
cancer (DTC)
by measuring their blood levels of anti-Müllerian hormone (AMH) and following the patients for up to one year after
treatment.
«Since 95 percent of
cancer patients still get chemo, we realized we could make a major impact on
cancer treatment by helping clinicians prescribe the right chemotherapy drug,» said Sourav Bandyopadhyay, PhD, a professor of bioengineering and therapeutic sciences in UCSF's Schools of Pharmacy and Medicine and senior author on the new
study.
The first long - term
study of a pioneering endoscopic laser
treatment for early vocal - cord
cancer, developed at Massachusetts General Hospital (MGH) and previously shown to provide optimal voice outcomes, finds that it is as successful as traditional approaches in curing patients» tumors while avoiding the damage to vocal quality caused
by radiotherapy or
by conventional laser or cold - instrument surgery.
A new
study led
by University of Kentucky researchers suggests a new approach to develop highly - potent drugs which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the
treatment of
cancer as well as viral and bacterial infections.
Researchers at Oregon State University are pursuing a new concept in
treatment of epithelial
cancer, especially head and neck
cancer,
by using two promising «analogs» of an old compound that was once
studied as a potent anti-tumor agent, but long ago abandoned because it was too toxic.
«Children conceived after fertility
treatments are at increased risk for pediatric
cancers:
Study conducted
by Ben - Gurion University and Soroka University Medical Center.»
A
study by the
Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has found new interactions between two molecules involved in acute myeloid leukemia (AML), STAT3 and PRL - 3, which may offer a new therapeutic target for cancer trea
Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has found new interactions between two molecules involved in acute myeloid leukemia (AML), STAT3 and PRL - 3, which may offer a new therapeutic target for
cancer trea
cancer treatment.
In the analysis of 23 relevant
studies, investigators found that many clinicians are broadly informed about the risk to their patients» fertility brought about
by cancer treatment, but many factors hinder the appropriate discussions and referrals needed to provide adequate fertility support to patients of reproductive age.
An international
study led
by scientists from the Crick Institute in London and the Hebrew University of Jerusalem revealed a survival mechanism in
cancer cells that allows the disease to erupt again even after aggressive
treatment.
Studies show that the efficacy of some vaccines and
cancer treatments may be affected
by the time of day when a therapy is administered or medicine is taken.
A Yale
Cancer Center study may have solved this mystery by identifying how cancer cells escape treatment, leading to recur
Cancer Center
study may have solved this mystery
by identifying how
cancer cells escape treatment, leading to recur
cancer cells escape
treatment, leading to recurrence.
Despite findings of previous
studies and published guidelines, nearly two - thirds of patients with T4a larynx («voice box»)
cancer are not receiving a total laryngectomy (surgical removal of the larynx), the recommended form of
treatment, and as a result, have significantly worse survival rates versus those treated with a total laryngectomy, a new
study published in the International Journal of Radiation Oncology, Biology and Physics
by experts at Penn Medicine found.
However, Professor Anderson stressed that the results of the
study related only to subsequent pregnancy itself, and not to the incidence of infertility caused
by cancer treatment.
The
study, published in the journal Science Translational Medicine, is an important step towards use of «liquid biopsies» to revolutionise breast
cancer care —
by changing the way
cancer is monitored in the clinic and informing
treatment decisions.
By identifying novel biological pathways and publishing details of these interactions, the
study team aims to help uncover useful targets in developing better vaccines and
cancer treatments.
In a recent
study, published in Kidney International, researchers from Duke - NUS Medical School (Duke - NUS) in Singapore and Duke University have shown that drugs that target Wnt secretion
by inhibiting Porcupine, a protein usually targeted for
cancer treatment, may reduce renal fibrosis and protect the kidneys.
Through the
study, researchers were also able to pinpoint three different brain changes caused
by the progression of
cancer and the drugs used in
treatment.
The memory and thinking problems experienced
by cancer survivors, known as «chemo brain» or «chemo fog,» are not just the result of chemotherapy
treatment, they may start as tumors form and develop, suggests a Baycrest - led
study.
By matching normal and
cancer cells from a patient, we can now
study the differences — what molecules are key to tumor development and growth, and, ultimately, match
treatments that might disable this
cancer,» says the
study's senior investigator, associate professor of pathology, Xuefeng Liu, MD, a member of the Center for Cell Reprogramming (CCR) at Georgetown University Medical Center.
A
study led
by scientists at The Wistar Institute describes a novel immunotherapeutic strategy for the
treatment of
cancer based on the use of synthetic DNA to directly encode protective antibodies against a
cancer specific protein.
A
study by researchers at Brigham and Women's Hospital (BWH) found that brachytherapy
treatment was associated with better cause - specific survival and overall survival in women with cervical
cancer.
A recent
study by researchers at Sylvester Comprehensive
Cancer Center at the University of Miami Miller School of Medicine revealed that triple - negative breast cancer (TNBC), which has generally been unresponsive to hormone receptor - targeted treatments, can indeed be treated using vitamin D and androgen receptor - targeted th
Cancer Center at the University of Miami Miller School of Medicine revealed that triple - negative breast
cancer (TNBC), which has generally been unresponsive to hormone receptor - targeted treatments, can indeed be treated using vitamin D and androgen receptor - targeted th
cancer (TNBC), which has generally been unresponsive to hormone receptor - targeted
treatments, can indeed be treated using vitamin D and androgen receptor - targeted therapy.
The New EPOC
study, published in The Lancet Oncology and funded
by Cancer Research UK, evaluated whether the drug cetuximab and chemotherapy together worked better than chemotherapy alone as a treatment in addition to surgery for people with bowel cancer that had spread to the liver but could be surgically re
Cancer Research UK, evaluated whether the drug cetuximab and chemotherapy together worked better than chemotherapy alone as a
treatment in addition to surgery for people with bowel
cancer that had spread to the liver but could be surgically re
cancer that had spread to the liver but could be surgically removed.
Published
by Noha Sharafeldin, M.D., M.Sc., Ph.D., instructor in UAB's Institute for
Cancer Outcomes and Survivorship and Division of Hematology and Oncology, this
study helps add a missing piece to a long - unsolved puzzle about post-transplant effects on recipients, specifically that vulnerable subpopulations of similar transplants can benefit from targeted interventions in the years after they receive their lifesaving
treatment.
A
study led
by UCLA's Drs. Robert Prins and Linda Liau, both UCLA Jonsson Comprehensive
Cancer Center members, looked at the impact of a combined
treatment using a chemotherapy drug called decitabine and genetically modified immune cells or T cell immunotherapy.
A new
study led
by scientists at The Ohio State University Comprehensive
Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) suggests that dopamine — an inexpensive drug currently used to treat heart, vascular and kidney disorders — can be safely used in cancer treatment to curb the growth of blood vessels in t
Cancer Center — Arthur G. James
Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) suggests that dopamine — an inexpensive drug currently used to treat heart, vascular and kidney disorders — can be safely used in cancer treatment to curb the growth of blood vessels in t
Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) suggests that dopamine — an inexpensive drug currently used to treat heart, vascular and kidney disorders — can be safely used in
cancer treatment to curb the growth of blood vessels in t
cancer treatment to curb the growth of blood vessels in tumors.
Pembrolizumab, an antibody drug already used to treat other forms of
cancer, can be effective in the
treatment of the most common form of mesothelioma, according to a new
study led
by investigators from the Perelman School of Medicine at the University of Pennsylvania.
To determine whether the reactivation of methylation - silenced genes
by EGCG is a general phenomenon that also occurs in other cell lines, we
studied the effects of EGCG
treatment on the methylation status and mRNA levels of p16INK4a or RARβ in three other human
cancer cell lines (Fig. 3C) ⇓.
The
study results were published online June 1
by the journal Breast
Cancer Research and
Treatment, and were presented June 4 at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago.
As the researchers put it: «Our
study demonstrates that the disparity in testing is not explained
by differences in the doctors that black and white women see for their
cancer treatment.
The
study on racial disparities in prostate
cancer treatment was conducted
by the University of North Carolina Lineberger.
The scientists recently received a five - year, $ 1.6 million grant from the National Institute of Dental & Craniofacial Research, a part of the National Institutes of Health, to
study stem cells that may restore salivary gland tissue damaged
by cancer treatment.
Overweight pediatric
cancer patients who eat a healthy diet and exercise regularly may improve outcomes and reduce treatment side effects that cause disease, according to a review study led by researchers at MD Anderson Children's Cancer Hos
cancer patients who eat a healthy diet and exercise regularly may improve outcomes and reduce
treatment side effects that cause disease, according to a review
study led
by researchers at MD Anderson Children's
Cancer Hos
Cancer Hospital.
Moreover, PHENONIM - ICS is involved in European projects presenting a strong impact on human health: Interreg CARDIOGENE (Genetic mechanisms of cardiovascular diseases), GENCODYS (Genetic and epigenetic networks involved in cognitive dysfunctions), AgedBrainSYSBIO (Basic
studies of brain aging), as well as projects in partnership with industry: MAGenTA (an Industrial Strategic Innovation project supported
by Bpifrance about the
treatment of major urogenital diseases) and CanPathPro (H2020 program), to develop a predictive modeling platform of signaling pathways involved in
cancers.
He is currently funded (2016 - 2021)
by the National
Cancer Institute to study radiation induced changes in neuron cell dendritic morphology in cancer treatment with X-rays, protons and carbon beams, and has received grants from the Department of Energy and NASA in the
Cancer Institute to
study radiation induced changes in neuron cell dendritic morphology in
cancer treatment with X-rays, protons and carbon beams, and has received grants from the Department of Energy and NASA in the
cancer treatment with X-rays, protons and carbon beams, and has received grants from the Department of Energy and NASA in the past.
Permanent discontinuation of
study medication was required
by protocol for women who developed breast
cancer, endometrial pathologic state (hyperplasia not responsive to
treatment, atypia, or
cancer), deep vein thrombosis (DVT) or PE, malignant melanoma, meningioma, triglyceride level greater than 1000 mg / dL (11.3 mmol / L), or prescription of estrogen, testosterone, or selective estrogen - receptor modulators
by their personal physician.
Other
studies by CRI scientists that are shedding light on the understanding and
treatment of colorectal
cancer include:
«A number of these assays and associated bioinformatics software have been validated for use in Invivoscribe's own «LabPMM» clinical laboratories, and they are currently being used
by leading
cancer treatment centers and pharmaceutical partners, both to optimize
treatments for patients, and to stratify, enroll, and track residual disease in patients in international phase II and phase III clinical
studies.
Because Akt is an important factor in the differentiation and immune function of T cells, and previous
studies showed that VPA and other HDAC inhibitors could inhibit Akt activity in
cancer cells (41, 42), we examined whether Akt activity was modulated
by VPA
treatment.