We use gut as model system to
study cell migration in homeostasis, wound healing and cancer invasion (Fig. 1).
Not exact matches
Several labs are using the technology to
study topics such as
cell migration and neuroscience, he says.
at The Scripps Research Institute and the Burnham Institute, and also at the National Institutes of Health, where her
studies spanned signal transduction,
cell migration, and neuronal development.
This
study, published in the journal Microarrays, shows that lack of SOST in the bone microenvironment promotes the expression of many genes associated with
cell migration and / or invasion, including long non-coding RNA MALAT1 in prostate cancer, suggesting that SOST has an inhibitory effect on prostate cancer invasion.
In a new
study, NAIST scientists, in collaboration with researchers at the Osaka National Hospital and University of Tokyo, report that the L1
Cell Adhesion Molecule (L1 - CAM) is crucial for directed axon
migration.
A
study by Sofia J. Araújo, a Ramón y Cajal researcher with the Morphogenesis in Drosophila lab at the Institute for Research in Biomedicine (IRB), elucidates the genetic regulation of
cell migration.
One interesting finding from this
study was that the speed of
migration, maintained relatively constant throughout the life of a
cell, is not inherited from the mother down to the daughter
cells.
Cell migration has mainly been studied in cell culture environm
Cell migration has mainly been
studied in
cell culture environm
cell culture environment.
Kees Weijer of the University of Dundee in Scotland, who
studies the
migration of
cells in chick embryos and slime mold, has been waiting for a light sheet microscope since the EMBL group first publicized its advances.
It's a «very important» and «very thorough» paper, says James Woods, a microbiologist at Midwestern University in Downers Grove,, Illinois, who has
studied the
migration of RASFs: «The fibroblasts that were active, they are usually thought of as a resident [i.e., nonmobile]
cell.
The team explains that this is a step forward for research into
cell migration mechanisms and that future applications will emerge as further investigation and
studies are conducted.
«Cholesterol plays key role in
cell migration,
study shows.»
A team of researchers at the Massachusetts General Hospital and Harvard Medical School in Boston has developed technologies for precision measurement of
cell migration speed before and applied the new tool to
study the variations of
migration speed in population of cancer
cells.
In their
study, scientists around Prof. Olivier Pertz from the Department of Biomedicine at the University of Basel gained novel insights into the regulation of directional
cell migration: Using a special procedure, 20 micrometer wide lines were fabricated on glass thereby mimicking the connective tissue environment — creating a highway for
cells.
«In this
study, we found that enhanced neuropilin - 1 (NRP - 1) and NEDD9 levels in endometrial and lung cancer positively correlated with metastasis, while liver kinase B1 (LKB1) inhibited the
migration of cancer
cells.»
A
study has shown that the immunosuppressive effect of MSCs is mediated by the secretion of galectin - 3, a protein known to modulate T
cell proliferation, gene expression,
cell adhesion and
migration 44.
Open access microfluidic device for the
study of
cell migration during chemotaxis.
Future
studies of these
cells are expected to shed light on developmental diseases such as autism and schizophrenia and malformations of brain development, including microcephaly, lissencephaly and neuronal
migration disorders, they say, as well as age - related illnesses, such as Alzheimer's disease.
Furthermore, the authors hope that further
studies into the mechanisms of stem
cell mobilization /
migration and stem
cell differentiation into glomerular and tubular
cells could aid the development of this promising therapy.
In previous
studies using other donor
cell types, significant intraretinal
migration was not seen [39], [41], nor were pigment granules found in donor
cells not originally derived from RPE [39].
«In this
study, we used a combination of synthetic polymers and ECM proteins to fabricate biocompatible JetValves that are hemodynamically competent upon implantation and support
cell migration and re-population in vitro.
The
study also underscored that manipulating ACC may be a worthwhile avenue for treating
cell migration - related diseases.
Future
studies will clarify how the combination of stromal network structure, tumor
cell signaling and extracellular signaling cues influence cancer
cell migration and metastasis.
To date, chemotaxis in mammalian
cells has been primarily
studied using 2D
migration models.
Cell migration has traditionally been
studied in 2D substrates.
Multiple
studies have shown that fascin, through its role in formation of cellular protrusions such as filopodia and invadopodia, enhances cancer
cell migration and invasion in vitro.
«The present
study fills a gap in the literature by showing the relationship between the fatty acid metabolism and the
migration of endothelial
cells.»
Although originally
studied primarily in two - dimensional in vitro assays, most
cell migrations in vivo occur in complex three - dimensional tissue environments that are difficult to recapitulate in
cell culture or ex vivo Further, it is now known that
cells can mobilize a diverse repertoire of
migration modes and subcellular structures to move through and around tissues.
Our biological
studies suggest that a critically reduced amount of this protein alters
cell shape,
migration, proliferation, and gene expression to the detriment of brain, heart, and kidney development.
A «WOW» maple syrup finding: Take this 2015
study reported in Oncology Reports: the researchers examined the effect of three grades of maple syrup (grades are based on the color of the syrup and ranges from light to darker with color being influenced by time of year and processing technique) on the proliferation,
migration, and invasion of colorectal cancer (CRC)
cells in order to investigate whether maple syrup is suitable as a phytomedicine for cancer treatment.
In a
study observing its effects on ovarian cancer
cells and
cell - mediated responses, Reishi inhibited
cell colony formation and
cell migration demonstrating its ability to protect already healthy
cells.