Sentences with phrase «study cells involved»

The team is now working with doctors at Massachusetts General Hospital, who hope to use the new, noninvasive technique to study cells involved in cancer, asthma, and other conditions in which cell properties change as a disease progresses.

Not exact matches

«In everyday interactions with significant others, people often assume that momentary distractions by their cell phones are not a big deal,» another researcher involved in the study, Meredith David, said.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

His dissertation was to be on the god Eros, but it remained unwritten, as, in addition to his studies, Stern was busily involved in organizing revolutionary cells and obtaining weapons.

The objects of his study range from a class of molecules that have the basic self - duplicating property of living things, through cells which suggest purely physical systems, through animals which give increasing evidence of having minds, to human beings in whom streams of consciousness seem to involve continual choices of action, at the opposite pole from control by impersonal laws of nature.

«In animal studies, exercise has been shown to specifically affect the hippocampus, significantly increasing the growth of new neurons and cell survival, enhancing memory and learning, and increasing molecules that are involved in the plasticity of the brain,» Chaddock said.

Recent studies have indicated that infant colic, gastroesophageal reflux, and constipation can all be caused or aggravated by cow's milk allergy — or intolerance, as it is called since it is cell - mediated and has a slower onset than reactions which involve IGE antibodies.

Different studies suggest that bacteria present in the maternal gut could reach the mammary gland during late pregnancy and lactation through a mechanism involving gut immune cells.

Their study, reported in the journal PLoS Computational Biology, suggests that breast feeding not only taps the normal brain cells involved in secreting oxytocin.

Previous studies showed that, in depressed patients, lipid rafts sequester a protein involved in cell signaling, called GαS, keeping it from doing its job.

The goals of the study, published April 11, 2018 in the journal Cell Host and Microbe, were to find out if microbes were required for digestion and absorption of fats, to begin to learn which microbes were involved, and to assess the role of diet - induced microbes on the digestion and uptake of fats.

A related paper, involving Svendsen, his colleague Gad Vatine, PhD, and a team from University of California, Irvine, published the same day in the journal Cell Reports, used a similar approach to study Huntington's disease.

Chu says the study emphasizes that healthy cells need more than functional mitochondria — they need to support a kind of mitochondrial life cycle that involves continuous genesis, repair and recycling.

Our studies involve the use of a whole - cell patch clamp, an electrophysiological approach to measure the transmembrane current of a single cell, to identify the effects of herbs on the cardiovascular system.

«It was particularly exciting to observe that the repair of the skin epidermis involves the activation of very different stem cells that react the same way to the emergency situation of the wound and have the power to completely restore the damaged tissue», comments Mariaceleste Aragona, the first author of the study.

«I think this is the best option we have ever had,» says Renee Reijo Pera, director of Stanford University's Center for Human Embryonic Stem Cell Research and Education in California, who wasn't involved in the study.

The gene makes a protein that controls the quantities of other proteins a cell produces, and studies in roundworms suggest that the gene is involved in growth and development throughout life.

I had spent 4 years studying the interactions between two proteins involved in the cell cycle and DNA replication and repair.

The study «provided the surprising result that one new therapy currently being explored to lower insulin resistance promotes, rather than decreases, the formation of bone in mice,» says Darwin Prockop, a stem cell researcher at Texas A&M College of Medicine in Temple, who was not involved in the work.

The study involved laboratory cell lines of human leukemia and mouse models of the disease.

Identifying a role for tuft cells in the interactions between the virus and its host «is a significant step forward,» says immunologist David Artis of Weill Cornell Medicine in New York City, who was not involved in the study.

So far, researchers have mostly turned on genes with CRISPRa in cells growing in lab dishes, says Charles Gersbach, a biomedical engineer at Duke University not involved in the new study.

Several studies have supported a role for cancer stem cells in the aggressive brain tumors called glioblastoma, but those studies involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.

Non-melanoma skin cancers — specifically, basal cell carcinoma and squamous cell carcinoma — are more likely than melanoma to involve itch or pain, the study found.

While BPA did not affect the number of eggs retrieved, «it's worrisome that any compound could decrease productivity of the ovarian cells,» said Dr. Fred Licciardi, a specialist in reproductive medicine and surgery at the New York University Fertility Center who was not involved in the study.

By studying the receptor for thrombopoietin, called Mpl, on blood cells in the bone marrow, the team pinpointed the cells involved in making platelets after thrombopoietin stimulation, and made an unexpected discovery.

The new rules state that stem cells can be used if they are part of a study approved by the federal government, or if the protocol has been approved by an Institutional Review Board (IRB) that provides ethical review for research involving human volunteers.

Another strategy, which Steinman and others were studying, involves a therapy to target dendritic cells inside the body rather than taking them out and personalizing therapy for each patient.

Oral immunotherapy for peanut allergy induces early, distinct changes in immune T - cell populations that potentially may help researchers determine which people will respond well to the therapy and which immune mechanisms are involved in the response, a new study suggests.

Claustrophobic cells Three years ago, Gorbunova was involved in another study that described the unusual way in which the cells of the naked mole rat behave in the lab.

Future studies may involve infusion of higher numbers of altered cells.

Joseph Berry, senior research scientist at the National Renewable Energy Laboratory, who studies solar cells but was not involved in the research, said the research project is interesting because the device scales well and targets a specific part of the solar spectrum.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

The study involved 23 patients with relapsed or treatment - resistant HL, a cancer of white blood cells called lymphocytes.

Teaming up with her friend Xianlin, they studied GADD45a, a gene involved in cell growth regulation.

The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.

But this study hints that the rest periods between bouts of dieting, not the time spent cutting calories, may play an important role in nerve cell growth in mice, says Mark Mattson, a neuroscientist at the National Institute on Aging in Baltimore, Md., who wasn't involved in the study.

In earlier studies involving animal models and human cancer cell lines, researchers found that breast cancer spreads when three specific cells are in direct contact: an endothelial cell (a type of cell that lines the blood vessels), a perivascular macrophage (a type of immune cell found near blood vessels), and a tumor cell that produces high levels of Mena, a protein that enhances a cancer cell's ability to spread.

Studies of embryonic stem cells revealed that NANOG protein levels can be lowered by a chemical process known as methylation, which involves putting a methyl group chemical tag on a protein's messenger RNA (mRNA) precursor.

The researchers found five different sub-types of HL among the patients studied: 247 cases of the nodular sclerosis (NS) type, in which the tumour nodules are large; 105 of mixed cellularity, where a mixture of different types of inflammatory cells are involved; 58 lymphocyte rich, the sub-type with the best outcome; 68 «others»; and 143 «not otherwise specified» (NOS).

The method has allowed researchers to study key players involved in cell division — which include proteins that form much of the structure of chromosomes, and fragments of DNA that help to orchestrate the process.

In laboratory studies, daratumumab caused the targeted killing of CD38 - carrying tumor cells by several distinct and potent mechanisms, including some that involve the immune system.

Such cell - tracing techniques are the right approach to test the cancer stem cell model, says Sean Morrison, who studies stem cells and cancer at UTSMC and who was not involved in any of the studies.

The study suggests there may be «many more such instances of misidentification of animal species» — especially considering that the sunfish is relatively large and hard to miss — says Byrappa Venkatesh, a geneticist at the Institute of Molecular and Cell Biology in Singapore, who was not involved in the new research.

The study involved extracting Ribonucleic acid or RNA — found in the cells of all living organisms — to develop a transcriptome — the gene readouts in a cell — to examine what occurs during the different developmental stages of the cockroach pregnancy and to explore if those changes hold wider applications for other mammals.

The study included 124 newly diagnosed patients at 25 clinical trial sites in the U.S. Two - thirds of the patients were treated with ICT - 107, an experimental vaccine based on immune system cells called dendritic cells that were exposed to six synthetic proteins, or antigens, known to be involved in GBM development.

As an example, the current study identified and provided insight into the function of several genes, not previously known to be involved in the taste system, related to cell motility.

Studying breast and brain cancer cells in a hypoxia incubator, Uniacke and his team discovered that cadherin - 22 is involved in this process to enable the spread of cancer cells.

«Our study also indicates that the path towards iPS cells involves the use of specific control switches on DNA called enhancers,» adds Dr Constantinos Chronis from UCLA.

JAK1 is part of a well - studied regulatory network of proteins that is involved in the control of cell growth, differentiation, apoptosis, inflammation, and immune response.