Sentences with phrase «study disease biology»
One of the most fascinating, is through the creation of human «diseases in a dish,» which are giving scientists a better way to study disease biology and test new drugs.
http://www.closerlookatstemcells.org/ Not exact matches
Because, as Belmonte rightly explains, the new «precisely targeted» tools can help us «study species evolution, biology and disease, and may lead ultimately to the ability to grow human organs for transplant.»
He added that the method used in this study, called «network biology» — where computer systems are used to identify gene networks that work together to underpin disease — may also help find treatments for other conditions.
«Black children were slightly older at the first admission than white children, which could represent a subtle marker of diminished access to medical care or a delay in disease recognition,» said Dr. Dotson, who explained other studies have shown that the role of biology in health disparities in chronic diseases is often modest, and there are many other factors, such as access to care and health literacy, that contribute to disparities in care.
The study suggests that dwindling global environmental biodiversity and worldwide spikes in infectious diseases may be linked, said Jason Rohr, associate professor of integrative biology, University of Southern Florida.
Studies of the lens of the eye not only could reveal ways to prevent cataracts but also might illuminate the biology of Alzheimer's, Parkinson's and other diseases in which cells commit suicide
Xian - Cheng Jiang, PhD, professor of cell biology at SUNY Downstate Medical Center, has led a study identifying a new approach for lowering «bad» lipids in blood circulation, a critical means to combat devastating cardiovascular diseases such as atherosclerosis.
I've always been interested in healthcare, so while I was an undergraduate studying molecular biology I attended seminars on public health, human rights, and infectious disease management, which led directly to my current career path.
«Using the mathematics of evolution, you can really develop an engineerlike understanding of the disease,» says Martin Nowak, who studies mathematics and biology at Harvard University and has worked with Tomasetti and Vogelstein.
The aim of the institute is to develop and apply systems biology to biological studies relevant to human diseases.
The physician - scientist may study the same properties of the same molecule but for a different reason: because he or she believes that those studies will provide information on the fundamental pathology of a disease or insight into human biology that will provide a better understanding of healthy versus diseased states.
Studies comparing the mouse and human sequences that accompany the mouse genome in the journal Nature suggest it provides plenty of new leads in biology and disease.
But translation is not one - way; the insights gained at the bedside, and from clinical and population - based studies, will spawn hypotheses, enabling scientists to probe the mechanisms of disease in new ways and ultimately enriching basic biology.
«We hope that the results from this study will enable investigators to test the relevance of the maresin pathway in human disease,» said Charles N. Serhan, Ph.D., a researcher involved in the work from the Brigham & Women's Hospital and Harvard Medical School in Boston, Mass. «Moreover, we hope to better understand resolution biology and its potential pharmacology so that we can enhance our ability to control unwanted inflammation and improve the quality of life.»
Co-author Dr. David Hinds from 23andMe said: «While the genetics of hair colour is an interesting problem in itself, we hope that better understanding of the biology of melanin pigmentation will be applicable to studies of diseases that interact with pigmentation, such as skin cancer or vitiligo.»
The St. Laurent Institute, a non-profit medical research institute focused on the systems biology of disease, today announced in a study published in the July edition of Genome Biology, that genetic matter, previously ignored by the scientific community, may play an important role in cancer.
«This gives us a good technological platform for developing advanced malaria - control strategies, based on genetically modified mosquitoes unable to transmit the disease, and for studying the biology of malaria parasites in their mosquito hosts.»
«By learning more about how these cells work, we are one step closer to understanding the disease states in which these cells should be studied,» said Cagla Eroglu, an assistant professor of cell biology and neurobiology at the Duke University Medical Center, who led the research.
«Until now, no studies have separated how resistance to these two different drug actions might work,» says Roepe, also a professor of biochemistry and cell and molecular biology and co-founder of Georgetown's Center for Infectious Disease at Georgetown University Medical Center.
The study did not ascribe a specific cause for the racial disparities but offered six possible explanations: conscious or unconscious provider biases; patient mistrust; health literacy; patient - physician communication breakdown; healthcare access barriers; and / or race - based differences in disease biology.
The emphasis now is to store samples from almost every major study with correlative science in mind, and this is essential if we are to understand disease biology, mechanism of response and resistance to therapy in the era of targeted therapy and precision medicine.»
«Forty years ago, very little was known about breast cancer disease biology — such as subtypes, differences in radio - sensitivities, radio - resistances, local recurrence and in metastatic potential,» explains Bedrosian, the study's senior author.
Areas covered range from basic studies into the biology of innate and adaptive immunity (immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology) to immune contributions to health and disease (host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency).
The study was published in the leading molecular biology journal Molecular Cell and opens the door to further studies exploring new therapies for human polyglutamine repeat diseases.
The study's conclusions address a major challenge in current standards of care for prostate cancer: Without knowing a tumor's underlying biology, physicians can not reliably predict which of their patients will develop dangerous forms of the disease.
Investigative studies of human biology with an emphasis on disease, including small clinical trials
These studies demonstrate that inflammatory intestinal pathologies, such as Hirschsprung - associated enterocolitis or inflammatory bowel disease, can be explained as an overgrowth of certain pro-inflammatory groups of bacteria or a loss of anti-inflammatory bacteria, said Judith Eisen, a professor of biology and an expert on gut neurons in zebrafish.
«We think that for the first time, we have a mouse model of anorexia that closely resembles the conditions leading up to the disease in humans,» said study leader Lori Zeltser, PhD, associate professor of pathology & cell biology and a researcher in the Naomi Berrie Diabetes Center.
In recent years, the study of human biology has been shaken up by discoveries of how the bacteria that live in the gut, the so - called microbiome, affect metabolism, the immune system, and disease progression.
«Many mitochondrial diseases affect more than one system in the human body,» said Kateryna Makova, professor of biology and one of the study's primary investigators.
Our canine disease model offers new possibilities to study growth plate biology.»
Gottesman and Varmus were seeking the advisory panel's endorsement of a Ph.D. - granting program in disease - oriented, integrative biology that would enroll 15 students a year for a 5 - year course of study.
Physician - researchers from the International Mesothelioma Program at Brigham and Women's Hospital (BWH) have been caring for patients with mesothelioma for the past 25 years and, in parallel, studying the disease in the laboratory to better understand its biology and develop treatment strategies to target its vulnerabilities.
«Defining the biology of naturally occurring protective mutations is quite important, because they define desired outcomes for potentially new therapies,» explained the study's co-author Judy H. Cho, MD, Director of the Sanford Grossman Center for Integrative Studies in Crohn's disease, and the Charles F. Bronfman Institute for Personalized Medicine at the Icahn School of Medicine at Mount Sinai.
They also provide new information to determine when the mouse is an appropriate model to study human biology and disease, and may help to explain some of its limitations.
This allows us to study human disease by studying those aspects of mouse biology that reflect human biology.»
«The current study suggests a new link to the biology of Alzheimer's disease, even among people who do not show signs of memory impairment.»
Research scientist Salkeld and Antolin, professor and chair of biology in the College of Natural Sciences, assert that the swirl of ecological factors driving plague outbreaks in prairie dogs can lend key insights into the study of zoonotic diseases.
«Our work represents a unique intersection between the fields of biology and engineering that allowed for entirely new investigational strategies applied to the study of clinical disease,» says Animesh A. Sinha, MD, PhD, Rita M. and Ralph T. Behling Professor and chair of the Department of Dermatology in the UB School of Medicine and Biomedical Sciences and senior author on the study.
«Liver cancer is on the rise worldwide, and in human studies we've now seen that patients can progress from fatty liver disease to liver cancer without any middle steps such as cirrhosis,» says David Moore, a professor of molecular and cellular biology, who led the study with Associate Professor Loning Fu, both at Baylor.
Of note, the current study is part of a recent surge in NYU Langone findings on pancreatic cancer, including studies on how first - responder cells turn off the immune response, the role of the drug nab - paclitaxel in tumor biology, cancer cells» unique fuel sources, and how immune cell infighting drives the disease.
Scientists hope to use stem cells, which can develop into nearly any type of tissue in the body, to treat a variety of diseases as well as to study basic biology (ScienceNOW, 30 November).
It may also lead to improved therapies to fight sleeping sickness; current medications used to combat the disease have improved over the past decade but still include an old arsenic - based drug that kills between 5 and 10 percent of the people receiving treatment, said the study's senior author Stephen Hajduk, a professor of biochemistry and molecular biology in the UGA Franklin College of Arts and Sciences.
Focused both on discovery and on mentoring future generations of researchers, Salk scientists make groundbreaking contributions to our understanding of cancer, aging, Alzheimer's, diabetes and infectious diseases by studying neuroscience, genetics, cell and plant biology and related disciplines.
«Until now, it often has been a real mystery which antigens T cells are recognizing; there are whole classes of disease where we don't have this information,» said Michael Birnbaum, a graduate student who led the research at the School of Medicine in the laboratory of K. Christopher Garcia, the study's senior author and a professor of molecular and cellular physiology and of structural biology.
It also supports our belief that in the future, one might be able to use this approach for replacement of cells lost or malfunctioning due to other more common diseases of the retina,» said lead study author cell biologist Jason Meyer, Ph.D., assistant professor of biology in the School of Science at Indiana University - Purdue University Indianapolis.
«Studying what goes wrong in disease can provide us with important insights into basic biology and how it's supposed to go right,» said Deepak Srivastava, MD, director of the Gladstone Institute of Cardiovascular Disease and senior author on the newdisease can provide us with important insights into basic biology and how it's supposed to go right,» said Deepak Srivastava, MD, director of the Gladstone Institute of Cardiovascular Disease and senior author on the newDisease and senior author on the new study.
After observing important similarities between planarians and their disease - causing cousins, Newmark and former postdoctoral fellow Jim Collins (now a professor at UT Southwestern) took the radical step of applying their knowledge of planarians to studying schistosome biology.
This census, published in Nature, comprises a first - draft atlas of the small intestine's cellular composition, providing a reference for studying the biology of a host of conditions affecting or involving the gut, such as inflammatory bowel disease, cancers of the small intestine, celiac disease, and food allergies.
«This pairing of biology and engineering allows us to re-create an intestinal lining that matches that of a patient with a specific intestinal disease — without performing invasive surgery to obtain a tissue sample,» said Clive Svendsen, PhD, director of the Cedars - Sinai Board of Governors Regenerative Medicine Institute and a co-author of the study.