Sentences with phrase «study disease mechanisms»

The researchers realized this new approach had tremendous potential to screen drugs and to study disease mechanisms.

These models are useful for studying disease mechanisms, identifying targets, screening compounds and stratifying patients.

Not exact matches

These studies helped illuminate some of the molecular mechanisms by which these fungal pathogens cause disease in the banana.

The Global Burden of Disease Study 2010 predicted that sugar sweetened drink consumption contributes a relatively small amount to UK population morbidity (28000 disability adjusted life years) compared with low fruit and vegetable consumption (1130000 disability adjusted life years).59 Using revenue from a sugar sweetened drink tax to reduce the prices of fruit and vegetables is a potential mechanism for further improving population health.60

Another study found that maltodextrin impairs cellular antibacterial responses and suppresses intestinal antimicrobial defense mechanisms, leading to inflammatory bowel disease and other GI conditions that arise from an inappropriate immune response to bacteria.

«The study results elucidate the molecular mechanisms underlying disease progression in multiple sclerosis models, providing a basis for future clinical trials to determine safety and efficacy of these chemical agents in humans with demyelinating disorders,» says Patrizia Casaccia, MD, PhD, Professor of Neuroscience, Genetics and Genomic Sciences at Mount Sinai and senior author of the study.

He concludes, «Mounting evidence from ecological and observational studies, as well as studies of mechanisms, indicates that the Western dietary pattern — especially the large amount of meat in that diet — is strongly associated with risk of developing Alzheimer's disease and several other chronic diseases.

«Our study reveals a new mechanism that could be harnessed for biological therapies for lupus and other autoimmune diseases, where the immune system mistakenly targets the body's own cells,» says senior study author Boris Reizis, PhD, professor of Pathology and Medicine at NYU Langone.

This mechanism may be involved in many more diseases,» explains study's co-author, Dr. David Rosenblatt, a scientist in the Child Health and Human Development Program at the RI - MUHC and holder of the Dodd Q. Chu and Family Chair in Medical Genetics in the Department of Human Genetics at McGill University.

► On the News site on Sunday, Sarah C. P. Williams wrote about a recent study that suggests a possible mechanism for how stress can lead to cardiovascular disease.

If I had gone that other route, I would most likely be studying basic mechanisms of immunity rather than applying them to the study of infectious and autoimmune disease models.

While studying the inflammatory mechanisms underlying colitis in rodents, a team of researchers led by Dana Philpott and Thierry Mallevaey realized that their laboratory mice were more susceptible to developing the disease if their intestines were already infected with the protozoan Tritrichomonas muris.

«These two studies highlight the value of using an integrated multi-systems approach — including fruit flies, mice, and human cells — to discover mechanisms underlying disease processes.»

Prof. Schuelke emphasizes: «Our results are a good example of how the study of rare genetic diseases can provide insights into general disease mechanisms, which may also play a role in other conditions, such as paraplegia, and which may give rise to the development of regenerative therapies.»

«New mechanism of inheritance could advance study of evolution, disease treatment.»

But translation is not one - way; the insights gained at the bedside, and from clinical and population - based studies, will spawn hypotheses, enabling scientists to probe the mechanisms of disease in new ways and ultimately enriching basic biology.

The unravelling of these mechanisms may provide us with new tools to study diseases,» concludes Casanova.

Researchers say these results have implications for understanding disease origin rather than for clinical risk prediction and future studies should focus on the mechanisms underlying the relationship between childhood height and later stroke.

«We see that two completely different disease entities share a common pathogenic mechanism,» said George Hajishengallis, a professor of microbiology in Penn's School of Dental Medicine and an author on the study.

«Given the similarities in the molecules and the mechanisms involved in limb development in vertebrates and invertebrates, the fly is a very useful genetic model in which to identify new genes that potentially participate in limb development in vertebrates and their possible association with congenital diseases,» says Ana Ferreira, who has participated in the study.

In January researchers — following up with the Whitehall II study, begun in the 1980s — unveiled fresh details about the mechanisms underlying the now firmly established links among low job control, stress and high cardiovascular disease.

«Our aim was to study the mechanism underlying visual hallucinations in Parkinson's disease, as these symptoms are currently poorly understood.»

«Major study of genetics of breast cancer provides clues to mechanisms behind the disease.»

And although a few studies had shown a link between birthwort and either upper urinary tract cancer or kidney disease, they had only traced the mechanism as far as mutations on one gene: P53, a gene commonly associated with cancer.

Once they found that the OTULIN gene was abnormal in the sick children, they studied the immune pathway in order to understand the mechanisms of disease and to improve treatment of these patients.

«Results also identified mechanisms regulating the numbers and phenotype of macrophages in the tiny air sacs of the lungs (called alveoli) in health and disease,» said Takuji Suzuki, MD, PhD, the study's first author and a scientist in the Division of Neonatology and Pulmonary Biology at Cincinnati Children's.

By studying how these genes cause defects in fly and mouse models, we can improve our insights into the mechanisms related to human disease,» said corresponding author and Dr. Hugo J. Bellen, professor of neuroscience and molecular and human genetics at Baylor College of Medicine and an investigator at the Howard Hughes Medical Institute.

The transgenerational epigenetic mechanism of microRNA differed from a study that showed how treating the father's symptoms of an inherited disease can epigenetically treat the son.

The emphasis now is to store samples from almost every major study with correlative science in mind, and this is essential if we are to understand disease biology, mechanism of response and resistance to therapy in the era of targeted therapy and precision medicine.»

«Dr. Guo's study has identified a new mechanism of efficiently inhibiting biological processes that are critical to the function of the disease - causing organism, such that resistance is minimized or eliminated.»

The recent Finnish study clarified a mechanism underlying a severe progressive children's brain disease and adult's muscle disease.

They say this latest study raises questions about whether treatments that decrease the frequency or severity of migraine may reduce later life vascular risks, and conclude by saying «what little evidence we do have suggests the need for therapeutic restraint [to prevent cardiovascular risk] until we have a better understanding of the mechanisms underlying the link between migraine and vascular disease.»

«The study provides new insights into evolution and genetic adaptation, and establishes a framework for investigating the biological mechanisms behind disease resistance and adaptation to climate, knowledge that could be vital for protecting honeybees in a rapidly changing world,» says Matthew Webster.

PIND's goal is an integrated, interdisciplinary approach to the study of neurodegenerative diseases and their mechanisms, with the aim of transforming cutting - edge science into novel therapies and diagnostics that directly benefit individuals affected by neurodegenerative diseases.

The study also accelerates research into disease mechanisms and possible therapies.

Additionally, the researchers emphasized, the study highlighted connections between biological mechanisms that worsen disease not just in colon cancer but in certain chronic illnesses such as type 2 diabetes.

This enables them to study the mechanisms by which certain genes can predispose an individual to a particular disease.

«Our study highlights the sensory aspects of basal ganglia function and presents a new approach to the mechanisms behind the sensory impairments seen in Parkinson's disease,» says Gilad Silberberg, associate professor at Karolinska Institutet's Department of Neuroscience.

«Our study shows a whole new route, or bypass mechanism, for triggering the body's adaptive immune response to TB infection, a means by which infected dendritic cells cooperate with uninfected dendritic cells to activate T cells and respond to the infection,» says infectious disease specialist and study senior investigator Joel Ernst, MD, a professor at NYU Langone Medical Center.

An international study led by scientists from the Crick Institute in London and the Hebrew University of Jerusalem revealed a survival mechanism in cancer cells that allows the disease to erupt again even after aggressive treatment.

For the study, Ho and Kosik, leading experts in Alzheimer's research, compiled a list of 64 conceivable approaches to drug discovery, addressing a range of biological mechanisms that may be involved in the disease.

«We tried to untangle the large role aging appears to play in some of the most devastating neurological disorders,» said Edward Giniger, Ph.D., senior investigator at the NIH's National Institute of Neurological Disorders and Stroke and the senior author of the study published in Disease Models & Mechanisms.

While the mechanism by which a significant weight loss can reduce asthma - associated risks is unknown, studies have linked obesity to increased inflammation, higher prevalence of gastroesophageal reflux disease, and physical changes in the airway — all of which could contribute to asthma severity.

Now that they have shown how this defense mechanism works in cultured cells, they hope to study the importance of LINE - 1 jumping and the defenses against it in specific diseases.

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

In order to investigate the migratory mechanisms of various phagocytes, researchers usually study genetically modified mice which display inflammatory diseases.

A new study has uncovered a molecular mechanism in the prion protein, a protein responsible for neurodegenerative diseases, which may explain why nerve cells degenerate in these disorders.

Erlich and his team, which included researchers from Harvard, MIT, Stanford University, and Mount Sinai, plan next to study the effect of these eSTRs on more human diseases and better understand their molecular mechanism.

Over the last decade, large epidemiological studies have shown that kidney stone formers have an increased likelihood of developing other conditions such as hypertension, chronic kidney disease and heart disease; however, the mechanisms involved are unknown.

In various empirical studies, researchers have uncovered possible mechanisms that may explain differences in disease severity between dengue - infected individuals.