Sentences with phrase «study drug leads»
Not exact matches
«The intensifying battle for negotiating power and market share will lead companies to do acquisitions across traditional industry boundary lines,» said Erik Gordon, a professor at the Ross School of Business at the University of Michigan who studies the drug industry.
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George Budwell (Trevena): The clinical - stage biotech Trevena is set to release top - line results from two phase 3 studies (APOLLO - 1 and APOLLO - 2) for its lead drug candidate, oliceridine, in the first quarter of 2017.
Utah also leads the nation in the use of narcotic painkillers such as codeine and morphine - based drugs, the study found.
CNN: The spiritual but not religious likely to face mental health issues, drug use, study says Can being spiritual but not religious lead to mental health issues?
«If the right levels of the drug are not taken, as in they are too low or not regularly maintained, the virus can overcome the drug and become resistant,» Dr Ravi Gupta, lead author of the study, told the BBC.
Sean's father, Vineyard founder John Wimber was a selfdescribed former «beer - guzzling, drug abusing pop musician, who was converted at the age of 29 while chain - smoking his way through a Quaker - led Bible Study».
In this study, and in opposition to findings elsewhere, higher levels of social support were associated with greater depressive symptomatology, leading researchers to speculate that for low - income men the perceived costs of reciprocity may have deterred them from utilizing available support; or that peer groups may have influenced their alcohol or drug use, or placed demands on their resources (Anderson et al, 2005).
A new study in the Australian and New Zealand Journal of Gynaecology confirms what many who have undergone a hospital birth already know: the use of the labor - inducing drug pitocin (synthetic oxytocin) leads to great pain and suffering, including serious adverse, unintended health effects to both mother and infant.
Scores of animal and human studies show that early life stress, such as severe early social deprivation, leads to long - term changes in the brain, cognitive and social problems, and heightened susceptibility to anxiety, depression, and drug abuse in adulthood.
The study — led by James Murrough, associate professor of psychiatry and director of the Mood and Anxiety Disorders Program at Mount Sinai — chose the epilepsy drug ezogabine, which was given to 18 patients in a pilot trial.
As in cellular assays, the animal studies have shown that drug treatment leads to improvement in nuclear gem / Cajal body numbers in motor neurons.
Further, the effect was so strong in some participants that it was nearly comparable to that achieved with drugs specifically prescribed to treat gout, a new study led by Johns Hopkins researchers shows.
Stacy Salomonsen - Sautel, Ph.D, who was a postdoctoral fellow in the Department of Pharmacology, is the lead author of the study, which is available online in the journal Drug and Alcohol Dependence.
«It is exciting to have an expanded group of patients who are now eligible for this drug,» said Garon, whose clinical studies helped lead to today's FDA approval.
«What's frightening about this emerging street drug is that users themselves may not be aware that they are ingesting it,» said lead study author John Stogner, Ph.D. of the Department of Criminal Justice and Criminology at the University of North Carolina at Charlotte, N.C. «A patient may report heroin use and have symptoms consistent with heroin overdose, but an emergency physician may find that the standard dose of antidote (naloxone) doesn't work.
«This study has greatly helped us understand how the Ebola virus replicates and should at least allow us to test some new drug leads and hypothesis,» he said.
Randall Bond, an ER doctor and pediatrician at the Cincinnati Children's Hospital who led the study, says the uptick coincides with a dramatic boost in sales of opioid drugs.
«The next step is to identify antibodies and small - molecule drugs that can successfully target Helios or genes in the Helios pathway,» says the study's lead author, Hye - Jung Kim, PhD, of Dana - Farber.
Dr. McCabe said nanoparticles are a leading - edge technology also being studied for delivery of drugs for other conditions, such as cancer, heart disease, and bacterial infections, in order to target specific cells to reduce toxicity and side effects of those medications and to make them more effective.
An experimental drug in early development for aggressive brain tumors can cross the blood - brain tumor barrier, kill tumor cells and block the growth of tumor blood vessels, according to a study led by researchers at the Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James).
St. Jude Children's Research Hospital leads study showing that a drug withdrawn from the market in 2010 may enhance the effectiveness of bone marrow transplants for select pediatric leukemia patients
The results of the study, funded by the Malaria Eradication Scientific Alliance (MESA), are published in one of the world's leading medical journals The Lancet Infectious Diseases, and show that adding high doses of ivermectin, an endectocide class of drug, to the antimalarial dihydroartemisinin - piperaquine (DP) had a major and prolonged effect on mosquito mortality.
Treatment with the diabetes drug liraglutide, in combination with diet and exercise, led to a significant reduction in weight and improved a number of cardiovascular risk factors, including high blood pressure and high cholesterol, according to a multicenter study.
The study findings have already led to a collaboration with a pharmaceutical company to test drugs targeting that pathway, he said.
«Being bullied does not lead to higher substance abuse: Study examines bullying's impact on future drug, alcohol use.»
In a study published in the April issue of the Journal of Neuroscience, Saint Louis University scientists led by professor of pharmacological and physiological sciences Daniela Salvemini, Ph.D., discovered that drugs targeting the A3 adenosine receptor can «turn off» pain signals in the spinal cord to provide relief from chronic pain.
When combined with darunivir and a third drug, it led to undetectable virus in 82 percent of 82 patients, according to the study.
Lead author Markus Heilig of the NIH cautions that although the study is promising, it does not prove that the drug will help alcoholics long - term.
The drugs were thought to produce those effects through distinct molecular pathways, but according to a new study led by scientists at Temple University School of Medicine, both types of drugs may help the failing heart by counteracting the effects of an enzyme known as GRK2.
«Poor adherence with the Canadian pregnancy prevention guidelines means that Canada, inadvertently, is using pregnancy termination rather than pregnancy prevention to manage fetal risk from isotretinoin,» states lead author Dr. David Henry, senior scientist at the Institute for Clinical Evaluative Sciences (ICES) and executive co-lead of the Canadian Network for Observational Drug Effect Studies (CNODES).
«Microbes have long been known to «steal» drugs by converting them into inactive forms,» says Peter Turnbaugh of Harvard University, who led the study.
What's more, the studies suggest how our gut microbes make the immune system turn against nerve cells — a finding that could lead to treatments, like drugs based on microbial byproducts, that might improve the course of the disease.
Researchers from the Arthritis Research UK Centre for Genetics and Genomics at The University of Manchester, who led the study, warned that failure to take the drugs correctly, known as «non-adherence», reduced their effectiveness and may lead to a worsening of patients» disease.
The study underlines how investigations into the basic biological function of a drug target can lead in unexpected directions.»
According to the study's lead researcher, geneticist Albert La Spada of the University of California, San Diego, «the prospect of an oral drug is conceivable.»
The upshot, say Workman and others, is that many probes produce spurious results that can lead researchers to wrong conclusions about the proteins and drug molecules they are studying.
«One criticism of the PARP drugs is they are not active in patients who have developed resistance to other therapies, but we found veliparib appears to be effective in some platinum - resistant patients with recurrent or persistent disease,» said Robert L. Coleman, MD, lead author of the study and professor and vice chair of clinical research at the University of Texas MD Anderson Cancer Center, Houston.
An editorial in the same issue of the journal notes that drug - based treatments for liver cancer are limited and that the UT Southwestern study showed «truly remarkable results that should prompt further research under preclinical settings, given its potential to lead to a paradigm shift in treatment.»
The discovery of an unexpected biochemical link within tumor cells should lead to clinical trials for experimental drug treatments that indirectly target myc and that already are being evaluated in human studies, the researchers said.
«Prednisone is a strong and great drug for certain problems, but it is no better than antihistamine treatment for patients who are itching with hives,» said lead study author Caroline Barniol, MD, of the Centre Hospitalier Universitaire in Toulouse, France.
«Our work could lead not only to a better understanding of the biology of the optic nerve, but also to a cell - based human model that could be used to discover drugs that stop or treat blinding conditions,» says study leader Donald Zack, M.D., Ph.D., the Guerrieri Family Professor of Ophthalmology at the Johns Hopkins University School of Medicine.
Adult fruit flies given a cancer drug live 12 % longer than average, according to a UCL - led study researching healthy aging.
«No one's entertained the idea of developing a drug that affects FIH before, but I think our study will lead to greater examination of that possibility,» says Professor Johnson.
«Although we are disappointed that this particular drug did not prove successful, the field is benefiting from each study,» says lead author Lawrence Honig, MD, PhD, professor of neurology at CUIMC.
«We found that study participants were more apt to engage in transactional sex — the exchange of sex for drugs or money — if they did not complete high school and if their neighbors did not complete high school,» said the study's lead - author, Robin C. Stevens, PhD, MPH, Assistant Professor of Nursing and Director of the Health Equity & Media Lab.
Researchers studying the effects of general anesthesia recently made a startling discovery: the drugs used to knock out patients during surgery may lead to increased pain when they wake up.
«We urgently need new and better antimicrobial materials if we are to tackle drug - resistant bacteria,» said Dr Maria Ngu - Schwemlein, lead author of the study from Winston - Salem State University.
The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.
Alcohol addiction causes almost 3.8 per cent of deaths worldwide but a study led by QUT researchers offers new hope in the form of a drug already approved by the Food and Drug Administration (Fdrug already approved by the Food and Drug Administration (FDrug Administration (FDA).
«Drugs designed to boost insulin signaling could provide a treatment» for the disease, says Northwestern University neurobiologist William Klein, who led the study.