Sentences with phrase «study embryonic cells»
Similarly, the three research teams that last week reported turning mouse skin cells into embryolike cells say they will have to study embryonic cells to learn how to reprogram human cells in the same way and to understand their potential.
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However, embryonic stem cells remain the «gold standard,» and studies of all types of stem cells should continue in parallel for the foreseeable future.»
«Our new findings show that in the absence of embryonic movement the cells that should form articular cartilage receive incorrect molecular signals, where one type of signal is lost while another inappropriate signal is activated in its place,» Paula Murphy, a professor of zoology at Trinity College Dublin who co-led the study, says.
In a study in the journal Science, researchers explain how they used mouse embryonic stem cells and microchip technology to create heart muscle tissue that actually beats.
The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.
Although the U.S. government puts stringent restrictions on funding for research on embryonic stem cells, individual states such as California have set up institutes to perform that work and general stem cell studies.
«I think this is the best option we have ever had,» says Renee Reijo Pera, director of Stanford University's Center for Human Embryonic Stem Cell Research and Education in California, who wasn't involved in the study.
Some of the researchers at the centre will study the differentiation of stem cells into other cell types, one group by using human embryonic stem cell biology and another by studying early embryo development.
For example, animal studies have shown that neurons derived in the lab from human embryonic stem cells improve Parkinson's symptoms; however, any residual stem cells associated with those neurons could form masses of unwanted cells.
In the latest study, the researchers hypothesize that the downregulation of these three genes reprograms the cells so that they return to an embryonic - like state, in which they have the potential to give rise to a number of different cell types.
There have also been safety concerns confronting all hESC studies, including worries that the embryonic stem cells could proliferate out of control.
By exposing a magnetically responsive droplet (purple) to a magnetic field, the scientists are able to exert pressure on the surrounding embryonic cells in order to study their response to mechanical forces
The only previous demonstration — by researchers led by Shou - Wei Ding, PhD, a professor of Plant Pathology and Microbiology at UC Riverside and co-corresponding author of the current study — was done in embryonic stem cells and in newborn mice.
To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.
«Indeed, when we studied the mice at the embryonic stage, we saw the cells between the muscle fibers expanded explosively and formed tumors early in development,» Hatley said.
The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.
Studies of embryonic stem cells revealed that NANOG protein levels can be lowered by a chemical process known as methylation, which involves putting a methyl group chemical tag on a protein's messenger RNA (mRNA) precursor.
Partially paralyzed rodents walk almost normally after human embryonic or fetal brain stem cells repaired their spinal cord injuries in recent studies.
Mouse embryonic stem cells, reported in 1981 by Martin Evans, Matthew Kaufman, and Gail Martin, have allowed scientists to generate genetically customized strains of mice that have revolutionized studies of organismic development and immunity and have provided countless models of human disease.
Importantly, researchers must still study existing embryonic stem cell lines — the gold standard — to rule out any hidden risks in the lab - made cells, he says.
«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.
«It's just presumed that they have fewer capabilities than embryonic stem cells,» says Bill Lowry, a coauthor of the study.
The study, which followed four individuals for a year after they were treated with embryonic stem cell - derived retinal pigment epithelial cells for macular degeneration, observed no serious side effects (tumor growth or other unexpected effects) related to the therapy.
His work involves high - resolution imaging of chick embryonic tissue slices to study the cell - biological mechanisms driving neurogenesis in the spinal cord, for which Dr. Das played an instrumental role in pioneering new imaging technology.
This study provides experimental evidence which shows the important role of RNA levels in the controlling the fate of embryonic stem cells, and shows an understanding of RNA's ability to differentiate stem cells at the molecular level.
Embryology is a subfield, the study of organisms between the one - cell stage (generally, the zygote) and the end of the embryonic stage.
The new approach builds on information gleaned from developmental studies of embryonic stem cells (see story # 16) and one day may be used to create healthy replacements for harmed or diseased tissue.
Because fertilized human embryos are far more accessible than unfertilized eggs, which can not be frozen and stored, extending the result to humans could lower the practical barriers against creating human embryonic stem cells to study and potentially treat disease.
Experts say the new method, reported in the current issue of Cell, could also be a useful tool for studying embryonic development.
Eva Mezey, a stem cell biologist at the National Institutes of Health who published one of the transdifferentiation studies and stands by the effect, notes that embryonic cells are naturally more versatile than adult stem cells.
In a response to Friday's decision, NIH spokesperson John Burklow said NIH doesn't set aside fixed amounts of money for studying adult or embryonic stem cells, but instead makes award decisions based on scientific merit and relevance to NIH's priorities.
«New tools to study the origin of embryonic stem cells.»
Goldman's work builds on previous studies that explored the developmental cues involved in directing an embryonic stem cell to become a functioning neuron.
«We studied how the Sox2 gene is turned on in mice, and found the region of the genome that is needed to turn the gene on in embryonic stem cells,» said Professor Jennifer Mitchell of U of T's Department of Cell and Systems Biology, lead invesigator of a study published in the December 15 issue of Genes & Development.
«For several years, we have been studying myogenesis, a process by which muscles are formed during embryonic development,» says Jean - François Côté, PhD, Director of the Cytoskeletal Organization and Cell Migration research unit at the IRCM.
This discovery by the scientists at the CRG provides an insight into stem cell - forming molecular mechanisms, and is therefore of great interest for studies on the early stages of life, during embryonic development.
Thorough study of changes in the gene activity regulation mechanism showed that reprogrammed and embryonic stem cells are similar.
The lead author of the Minnesota study, Yuehua Jiang, counters that the same reservations apply to embryonic stem cells: «Are they cultured naturally?»
To investigate in more detail, researchers from KU Leuven and elsewhere employed in vitro fertilization in cattle as a flexible system to study chromosomal changes in single embryonic cells.
They then studied the state of X chromosomes in naïve cells of female embryos», which each contain two active X chromosomes, unlike more mature embryonic cells that have silenced one X.
A new study in Nature Genetics identifies a specific population of pluripotent embryonic stem cells that can reprogram to totipotent - like cells in culture.
UC announced yesterday that it is the first research institution to seek to «intervene,» or become a party in the case, in which the government is appealing a lower court's ruling that National Institutes of Health (NIH) funding to study human embryonic stem cells (hESCs) violates federal law.
«Studies on embryonic development greatly benefit from the culture system of embryonic stem cells and, more recently, induced pluripotent stem cells.
Continued support for biomedical research, and opposition to human embryonic stem cell studies.
Although Morrison doesn't study embryonic stem cells — his area is adult stem cells, including how they develop into cancer cells — he pushed for a 2008 ballot proposal in Michigan that overturned a law restricting hESC research.
Studying mouse embryonic stem cells, they removed Grb2, a protein essential to the ability of the stem cell to transform into other cell types, from the cells.
John Gearhart, a stem cell researcher at Johns Hopkins University in Baltimore, Maryland, says the study «appears to be the best so far» at offering a potential alternative to human embryonic stem cells.
Shortly after his inauguration, Bush ordered a review of the current National Institutes of Health (NIH) policy, which allows the funding of embryonic stem cell studies as long as researchers receive the cells from privately funded researchers who have derived them in accord with a set of ethical guidelines (ScienceNOW, 23 August 2000).
The study, published today in the journal Cell Stem Cell and led by Dr. Shunsuke Ishii from RIKEN, sought to identify the molecule in the mammalian oocyte that induces the complete reprograming of the genome leading to the generation of totipotent embryonic stem cells.
In a series of studies published since 2009, researchers in Wells» laboratory used human pluripotent stem cells (hPSCs) to grow embryonic - stage small intestines with a functioning nervous system, and the antrum and fundus regions of the human stomach.