Sentences with phrase «study epigenetic changes»

Natarajan has been at the forefront of research on the complications of diabetes and the first to study epigenetic changes in diabetic vascular complications and metabolic memory.

Stroud was interested in studying epigenetic changes, or chemical modifications that turn genes on and off, in DNA for the glucocorticoid receptor gene that regulates passage of cortisol from mother to fetus.

Not exact matches

De novo mutations and epigenetic changes could both be contributing factors in another recent study linking a father's age to stillbirth, pre-term birth and low birth weight.

«Our study suggests that epigenetic changes to cells treated with cigarette smoke sensitize airway cells to genetic mutations known to cause lung cancers,» says Stephen Baylin, M.D., the Virginia and D.K. Ludwig Professor for Cancer Research and professor of oncology at the Johns Hopkins Kimmel Cancer Center.

Baylin and Johns Hopkins scientist Michelle Vaz, Ph.D., first author on the study, suspected that the interplay of epigenetic and genetic changes may occur when normal lung cells develop into cancer, but, Baylin says, the timing of such changes was unknown.

The study suggests that epigenetic changes drive the aging process, and that those changes may be malleable.

«There's a complex interplay between hormones, experience and epigenetic changes in response to life events,» says neuroscientist Cheryl Sisk, who studies sex differences in the brain at Michigan State University in East Lansing.

Preliminary data from another study of theirs suggest that Fresno youth, by moving elsewhere to attend college, might see a reversal of some epigenetic changes to their immune cells.

Some studies also suggest that these epigenetic changes are heritable.

In a new study published in the Journal of Allergy and Clinical Immunology, researchers have now found a new principle for how epigenetic changes can occur.

In a new study, researchers at Uppsala University have found evidence of a new principle for how epigenetic changes can occur.

A new study suggests that epigenetic effects — chemical modifications of the human genome that alter gene activity without changing the DNA sequence — may sometimes influence sexual orientation.

In a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes.

Another study by a different group in the same journal in October 2009 looked at ART effects on epigenetics (non-DNA changes in genes) in humans.

Such epigenetic mechanisms are high on the list of suspects when it comes to explaining how environmental factors that affect parents can later influence their children, such as in the Dutch second world war study, but just how these epigenetic changes might be passed on to future generations is a mystery.

And because epigenetic changes typically occur early in life, it may one day be possible to identify young people at risk for suicide by studying their methylation patterns and then to treat them with drugs that regulate this mechanism, Szyf notes.

They also collected DNA to study epigenetics — changes in the activity of how a gene is expressed through environmental experiences, rather than alteration of the genetic code itself.

The researchers performed a «genome - wide» study in children with newly diagnosed CD, before any treatment, to look for possible epigenetic changes that may affect gene behavior.

A new study finds a wide range of epigenetic changes — alterations in DNA across the genome that may be related to key environmental exposures — in children with Crohn's disease (CD), reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America (CCFA).

«Epigenetic changes in children with Crohn's disease seen in study.»

In a study appearing February 18 in Cell Metabolism, researchers link this difference to an epigenetic change in the stressed dad's sperm — a change that they could prevent by blocking the father's stress hormones.

This study should inform those who restrict their view of epigenetic changes to only DNA methylation.

The study of epigenetic changes in the body's hormone - based stress system has shown that stress - related changes in the CRH gene are linked to both serious suicide attempts in adults and psychiatric illness in adolescents.

This is the first study to demonstrate an epigenetic model of nitric oxide signaling that has the potential to «change our fundamental understanding of both nitric oxide biology and epigenetic regulation,» Thomas said.

A new study shows that the choice of fat causes epigenetic changes which in turn could contribute to differences in fat storage.

Fernald's work suggests that epigenetic processes may cause, rather than simply reflect, changes in dominance status in hierarchically organized species, said Tom Boyce, a professor at the University of California, San Francisco School of Medicine, who was not involved in the study.

The study, published in Nature Communications, looks at epigenetic changes called DNA methylation, where methyl group chemicals modify DNA without changing its sequence.

Romain Barrès, who studies the genetics of metabolism at the University of Copenhagen, wanted to see whether there was evidence of such epigenetic changes in human sperm.

«The study confirms our previous assumptions that epigenetic changes may contribute to the development of type 2 diabetes» says Charlotte Ling.

Because the epigenetic study looked at the broader genome of NK cell DNA, not just at the IL - 10 gene, Tarrio added, the researchers can now go back to the data to look for other proliferation - induced changes.

Published in the Journal of Child Psychology and Psychiatry, this study is the first to indicate that epigenetic changes evident at birth may explain the link between unhealthy diet, conduct problems and ADHD.

But if these so - called epigenetic changes persist once the child is born and has children of its own, some of those offspring may be homosexual, the study proposes.

Various previous studies had shown that epigenetic remodeling of DNA by methylation or demethylation led to changes located in synapses, where one neuron communicates with another by chemical or electrical signals sent across a small gap.

In a companion study also published in Science, Nick Haining, MD, and colleagues from Dana - Farber Cancer Institute, also found a distinct epigenetic landscape for exhausted T cells in mice and humans, and they were able to ascribe key functions in T cell exhaustion to some of these epigenetic changes.

In their study, published online today in The Quarterly Review of Biology, the authors propose that differences in sensitivity to sex hormones result from «epigenetic» changes.

But in that study, the authors could not determine whether the epigenetic changes were a consequence of being overweight or the cause of the obesity in the first place.

In the current study, the researchers examined epigenetic changes in people who have had a previous heart attack.

A new study, by researches at Uppsala University, shows now that the memory of a heart attack can be stored in our genes through epigenetic changes.

It is therefore likely that it also occurs epigenetic changes associated a heart attack», says Åsa Johansson, a researcher at the Department of Immunology, Genetics and Pathology, who led the study.

Epigenetics is the study of changes to DNA packaging that influence which genes are expressed but don't affect the DNA sequence itself.

Epigenetics is the study of changes in organisms caused by modifying gene expression — by alcohol, for example — rather than alteration of the genetic code itself.

«Instead of looking solely at the genes directly implicated in autism through their genetic code changes, we really should be also studying the functions of the other genes implicated by these changes in genetic code through epigenetic connections.»

He studies how structural changes to chromosomes impact gene expression and cell fate with a focus telomere, telomerase, and chromosomal stability, epigenetic proteins, and the role of the SOSS complex in DNA damage repair.

«We are currently designing a large human study that will test to what extent epigenetic changes underlie this process.»

However, researchers have been skeptical of blood - based epigenetic studies for one main reason: While the genome is the same in any cell from the same individual, the epigenome necessarily changes from tissue to tissue.

This new area of science is called epigenetics, the study of how different environmental and lifestyle factors can alter how our genes behave, without actually changing our genetic makeup [source: Science].

The study of epigenetics is dealing with the processes that control the use of genetic information through changing chromatin structure.

In a new study published in the journal Science, a team of researchers has described how DNA - binding proteins (called transcription factors) react to and interpret these «epigenetic» changes.

Although the experiment's findings are restricted to roundworms and can not be extrapolated to humans, it does mark an important milestone in the study of the long - lasting effects of epigenetic changes.

Finally, our study highlights the importance of epigenetics in T2D as adipose tissue from unrelated subjects with the disease exhibit genome - wide methylation changes.