Sentences with phrase «study gene function»

Employs mouse models of human eye disease to study gene function and mechanisms underlying disease pathology.

The SKIP - e bioinformatics system has been developed to assist researchers in selecting antisense oligonucleotides that can be used as therapeutic agents to restore the production of a functional deleted protein such as for DMD or as tools to study gene function through the inactivation of a protein through nonsense mediated decay.

In addition, with the advancement of genetic techniques it has become an excellent model to study the gene function in vivo.

We are now using these models to study the gene function and complex mechanisms underlying disease pathways, with a focus on genetic background effects, genetic modifiers and interaction partners.

This is the first time that genome editing has been used to study gene function in human embryos, which could help scientists to better understand the biology of our early development.

stem used by geneticists to study gene function.

«This is a great tool to study gene function in a single cell,» he says.

Small RNA molecules originally developed as a tool to study gene function trigger a mechanism hidden in every cell that forces the cell to commit suicide, reports a new Northwestern Medicine study, the first to identify molecules to trigger a fail - safe mechanism that may protect us from cancer.

«We didn't have any reverse genetics resource for wheat, and it was absolutely necessary for us to study gene function,» Dubcovsky says.

In order to study gene function, the EUMODIC consortium produced mouse lines which each had a single gene removed.

«CRISPR - on is a tool that will be very useful for studying many biological processes, particularly for studying gene functions and gene networks,» says Whitehead Founding Member Rudolf Jaenisch.

«While they're useful for studying gene function in an animal, they also have their own inherent interest,» Melton says.

In animals such as mice, it is fairly routine to study gene functions by deleting a target gene or replacing it with an artificial piece of DNA.

Researchers typically use viruses for two types of studies --(1) knock - in; introducing a protein - coding gene into cells to study its function, or (2) knockout / knockdown; studying gene function through deletion (potentially using CRISPR lentivirus knockout libraries) or reduction of gene expression, respectively.

Transgenic mice are extremely useful for scientists studying gene function or regulation and human diseases, such as Alzheimer's disease.

We use various approaches including genetics, genomics and cell biology to study gene functions in normal development and disease such as cancer.

«Studying gene function in cancer cells is now a lot more straightforward and will continue to get easier as even newer technologies are developed,» says Waldman.

Not exact matches

As of the early 2000s, the study of gene structure and function, molecular genetics, has been amongst the most prominent sub-field of molecular biology.

The study links fox domestication to changes in gene activity in the pituitary gland, a brain center that kicks out hormones to regulate various bodily functions, including the stress response.

It studies altered gene functions that are not due to a change in the DNA sequence, but may nevertheless be inherited.

In the current study, researchers analyzed 48 ethnically diverse patients diagnosed with schizophrenia, looking at symptom sets in patients found to have rare or previously unknown changes in the DNA code of the four genes that disrupted brain function.

Studies have shown that more than 50 % of all human cancers carry defects in the p53 gene, and almost all other cancers with a normal p53 function carry other defects which indirectly impair the cancer - fighting function of p53.

Because the prion - forming protein identified in the study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter genetic expression and bacterial behavior.

Dr Antonio Pardiñas, first author of the study, said: «We show for the first time that genetic variants that do not severely impact gene function, but presumably have a more subtle impact on these critical genes, increase risk for developing schizophrenia.»

«A recent study identified over 100 genes associated with schizophrenia risk, but their functions are largely unknown,» said Yingwei Mao, associate professor of biology at Penn State and lead author of the study.

In this latest study, investigators found that replacing the MTM1 gene, which is mutated in patients, leads to sustained preservation of muscle strength and neurologic function in dogs over 4 years.

Korenberg was the early pioneer of studying these individuals with partial gene deletions as a way of gathering clues to the specific function of those genes and gene networks.

«The study analysed the genome of these eight species and performed comparative analysis of animal genes important for signalling, neuronal and ionic conduction, epithelia, immunity and reproduction, which are the basic functions associated to multicellularity,» she adds.

The institute will combine under one roof the various kinds of expertise needed to perform studies of gene function on a large scale.

It is the first time anybody has looked at the function of nearly every gene in an animal,» says Julie Ahringer at Cambridge University, UK, who led the study.

Although they have not been implicated directly in pancreatic function, genomewide association studies have linked the presence of a mutation near the genes to an impaired ability to properly manage fasting blood - glucose levels.

Previous studies have looked mainly at genes causing atherosclerosis and genes affecting the function of platelets and clotting processes as risk factors for ischemic stroke (clot obstructing blood flow to the brain).

«The power of this study is that we looked at genes discovered to be over-expressed in patients» tumors and determined their function in kidney cancer, which has not been done on a large scale before,» he says.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Delivering a single injection of a scar - busting gene therapy to the spinal cord of rats following injury promotes the survival of nerve cells and improves hind limb function within weeks, according to a study published April 2 in The Journal of Neuroscience.

Large - scale methods of probing samples, such as DNA sequencing, microarrays, and automated gene - function studies, are filling new databases to the brim.

In the next phase of the study, we will examine and categorize the functions of the genes that we identified — not only in model organisms, but also in agriculturally and economically important crops such as corn.»

The celiac study followed 6,403 newborn children with either of two high - risk gene groups called HLA that are important for immune function — HLA - DR3 - DQ2 or HLA - DR4 - DQ8 — to see who would develop celiac disease or CDA.

These genes are believed to be essential for the normal function of nerve cells, and previous studies have linked these mutations to problems with synaptic function — how neurons communicate with each other.

The three Ras genes found in humans — H - Ras, K - Ras and N - Ras — were among the first to be linked to cancer development, and a new study led by VCU Massey Cancer Center researcher Paul Dent, Ph.D., has shown the recently approved breast cancer drug neratinib can block the function of Ras as well as several other oncogenes through an unexpected process.

We are currently experimentally studying the function of many of these genes to gain a better functional understanding of the plant microbiome.»

«If we want to engineer the right microbiome to support plant growth, we need to understand the real function of the microbiome and not just sequence marker genes,» said study co-first author Asaf Levy, a research scientist at the JGI.

In the first study to show that the sensations from sampled alcohol vary as a function of genetics, researchers focused on three chemosensory genes — two bitter - taste receptor genes known as TAS2R13 and TAS2R38 and a burn receptor gene, TRPV1.

As an example, the current study identified and provided insight into the function of several genes, not previously known to be involved in the taste system, related to cell motility.

A given gene may perform a different function in breast cancer cells than in healthy cells due to changes in networks of interacting proteins, according to a new study published in PLOS Computational Biology.

To confirm these observations, both studies disabled the ap2 - g gene by cutting it out of the genome to remove its function from the parasite and the manipulated parasites indeed lost the ability to generate sexual - stage parasites.

After his team first observed hair loss in Treg - deficient mice, Rosenblum learned that the genes associated with alopecia in previous studies are almost all related to Tregs, and treatments that boost Treg function have been shown to be an effective treatment for the disease.

The next phase of study involving the newly discovered gene mutations will investigate their function using human blood samples at the molecular level.

The cellular functions that Finch studied for his «second Ph.D.» included the activation of the gene that encodes tyrosine aminotransferase (TAT).

«C. elegans is a powerful tool for biological research because it shares many of the same anatomic and cell functions as humans, and their short lifespan (average 17 days) enables us to study genes and measure cell traits in just two to three weeks.»